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현재 페이지 위치 : 삼성유전체연구소 > RESEARCH > Publications


Publications 2016

1. Yoo CE, Moon HS, Kim YJ, Park JM, Park D, Han KY, Park K, Sun JM, Park WY.
Highly dense, optically inactive silica microbeads for the isolation and identification of circulating tumor cells, Biomaterials, 2016 Jan;75:271-8.

2. Song HN, Lee C, Kim ST, Kim SY, Kim N, Jang J, Kang M, Jang H, Ahn S, Kim SH, Park Y, Cho YB, Heo JW, Lee WY, Park JO, Lim HY, KangWK, Park YS, Park WY, Lee J, Kim HC.
Molecular characterization of colorectal cancer patients and concomitant patient-derived tumor cell establishment, Oncotarget, 2016 Feb 20; 7(15):19610-9

3. Nam JY, Kim NY, Kim SC, Joung JG, Park PJ, Park WY.
Evaluation of somatic copy number estimation tools for whole-exome sequencing data, BRIEFINGS IN BIOINFORMATICS, 2016 Mar;17(2):185-92

4. Kim N, Cho A, Watanabe H, Choi YL, Aziz M, Kassner M, Joung JG, Park A, Francis JM, Bae JS, Ahn S, Kim KM, Park JO, Park WY, Ahn MJ, Park K, Koo J, Yin HH, Cho J.
Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation., Oncotarget, 2016 Mar 22;7(12):13797-809.

5. Gim J, Cho YB, Hong HK, Kim HC, Yun SH, Wu HG, Jeong SY, Jeong JG, Park T, Park WY, Lee WY.
Predicting multi-class responses to preoperative chemoradiotherapy in rectal cancer patients, Radiation oncology, 2016 Mar 22;11(1):50

6. Joung JG, Bae JS, Kim SC, Jung HC, Park WY, Song SY.
Genomic characterization and comparison of multi-regional and pooled tumor biopsy specimens, PLoS One, 2016 Mar 24;11(3):e0152574

7. Kim KT, Lee HW, Lee HO, Song HJ, Jeong da E, Shin S, Kim H, Shin Y, Nam DH, Jeong BC, Kirsch DG, Joo KM, Park WY.
Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma, Genome Biology, 2016 Apr 29;17(1):80

8. Sohn SY, Park WY, Shin HT, Bae JS, Ki CS, Oh YL, Kim SW, Chung JH.
Highly concordant key genetic alterations in primary tumors and matched distant metastases in differentiated thyroid cancer, Thyroid, 2016 May;26(5):672-82.

9. Chung J, Son DS, Jeon HJ, Kim KM, Park G, Ryu GH, Park WY, Park D.
The minimal amount of starting DNA for targeted capture massively parallel sequencing, Scientific Reports, 2016 May 25;6:26732

10. Ryu D, Kim HJ, Joung JG, Lee HO, Bae JS, Kim SJ, Kim H, Park WY, Kim K.
Comprehensive genomic profiling of IgM multiple myeloma identify IRF4 as a prognostic marker, Oncotarget, 2016 Jul 26;7(30):47127-47133.

11. Bae JS, Kim NK, Lee C, Kim SC, Lee HR, Song HR, Park KB, Kim HW, Lee SH, Kim HY, Lee SC, Jeong C, Park MS, Yoo WJ, Chung CY, Choi IH, Kim OH, Park WY, Cho TJ.
Comprehensive genetic exploration of skeletal dysplasia using targeted exome sequencing, Genetics in Medicine, 2016 Jun;18(6):563-9.

12. Ryu D, Joung JG, Kim NK, Kim KT, Park WY.
Deciphering intratumor heterogeneity using cancer genome analysis, Human Genetics, 2016 Jun;135(6):635-42

13. Cho SY, Bae JS, Kim NK, Forzano F, Girisha KM, Baldo C, Faravelli F, Cho TJ, Kim D, Lee KY, Ikegawa S, Shim JS, Ko AR, Miyake N, Nishimura G, Superti-Furga A, Spranger J, Kim OH, Park WY, Jin DK.
Biglycan (BGN) mutations in X-linked Spondyloepimetaphyseal Dysplasia, American Journal of Human Genetics, 2016 Jun 2;98(6):1243-8

14. Yoo KH, Kim NK, Kwon WI, Lee C, Kim SY, Jang J, Ahn J, Kang M, Jang H, Kim ST, Ahn S, Jang KT, Park YS, Park WY, Lee J, Heo JS, Park JO.
Genomic Alterations in Biliary Tract Cancer Using Targeted Sequencing, Translational Oncology, 2016 Jun;9(3):173-8.

15. Kang HG, Lee JK, YH Ahn, JG Joung, J Nam, NY Kim, Ko JM, Cho JH, Shin JI, Kim, Park HW, Park YS, Ha IS, Chung WY, Lee DY, Kim SY,Park WY, Cheong HI.
Targeted exome sequencing resolves allelic and genetic heterogeneity in genetic diagnosis of nephronophthisis-related ciliopathy, EXPERIMENTAL AND MOLECULAR MEDICINE, 2016 Aug 5;48(8):e251

16. Kim SJ, Shin HT, Lee HO, Kim N, Yoon JW, Hwang JH, Kim K, Park WY.
Recurrent mutations of MAPK pathway genes in multiple myeloma but not in amyloid light-chain amyloidosis, Oncotarget, 2016 Sep15;7(42):68350-9

17. Park K, Lee E, Park YH.
Association between mutation and expression of TP53 as a potential prognostic marker of triple-negative breast cancer, Cancer Research and Treatment, 2016 Oct;48(4):1338-1350

18 Ji Yun Lee, Kyunghee Park, Eunjin Lee, TaeJin Ahn, Hae Hyun Jung, Sung Hee Lim, Mineui Hong, In-Gu Do, Eun Yoon Cho, Duk-Hwan Kim, Ji-Yeon Kim, Jin Seok Ahn, Young-Hyuck Im & Yeon Hee Park.
Gene Expression Profiling of Breast Cancer Brain Metastasis, Scientific Reports, 2016 Jun 24;6:28623.

19. Min BH, Hwang J, Kim NK, Park G, Kang SY, Ahn S, Ahn S, Ha SY, Lee YK, Kushima R, Van Vrancken M, Kim MJ, Park C, Park HY, Chae J, Jang SS, Kim SJ, Kim YH, Kim JI, Kim KM.
Dysregulated Wnt singalling and recurrent mutations of the tumour suppressor RNF43 in early gastric carcinogenesis, Journal of Pathology, 2016; 240(3):304-314

20. Bae JS, Koh I, Cheong HS, Seo JM, Kim DY, Oh JT, Kim HY, Jung K, Sul JH, Park WY, Kim JH, Shin HD.
A genome-wide association analysis of chromosomal aberrations and Hirschsprung disease, Translational Research, 2016 Nov;177:31-40

21. Um SW, Joung JG, Lee H, Kim H, Kim KT, Park J, Park WY.
Molecular evolution patterns in metastatic lymph nodes reflect the differential treatment response of advanced primary lung cancer, Cancer Research, 2016 Nov.76(22)

22. Yoo CE, Park JM, Moon HS, Joung JG, Son DS, Jeon HJ, Kim YJ, Han KY, Sun JM, Park K, Park D, Park WY.
Vertical Magnetic Separation of Circulating Tumor Cells (CTC) and Somatic Mutation Analysis in Lung Cancer Patients, Scientific Reports, 2016 Nov 28;6:37392 doi:10.1038

23. Park DH, Huh HJ, Kim YJ, Son DS, Jeon HJ, Im EH, Kim JW, Lee NY, Kang ES, Kang CI, Chung DR, Ahn JH, Peck KR, Choi SS, Kim YJ, Ki CS, Park WY.
Analysis of intrapatient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus, Cold Spring Harbor Molecular Case Studies, 2016 Nov;2(6):a001214

24. Yi JH, Jang J, Cho J, Do IG, Hong M, Kim ST, Kim KM, Lee S, Park SH, Park JO, Park YS, Kang WK, Lim HY, Lee J.
MerTK is a novel therapeutic target in gastric cancer, Oncotarget, 2015 Apr 20. [Epub ahead of print]

25. Joung JG, Ha SY, Bae JS, Nam JY, Gwak GY, Lee HO, Son DS, Park CK, Park WY.
Nonlinear tumor evolution from dysplastic nodules to hepatocellular carcinoma, Oncotarget, 2017 Jan 10;8(2):2076-2082.

26. Park E, Lee JM, Ahn YH, Kang HG, Ha II, Lee JH, Park YS, Kim NK, Park WY, Cheong HI.
Hepatorenal fibrocystic diseases in children, Pediatrics, 2016 Jan;31(1):113-9.

27. Ahn KS, Lee JH, Park JM, Choi HN, Lee WY.
Luminol chemiluminescence biosensor for glycated hemoglobin (HbA1c) in human blood samples, BIOSENSORS & BIOELECTRONICS, 2016 Jan 15;75:82-7

28. Ham JS, Kim S, Kim HK, Byeon S, Sun JM, Lee SH, Ahn JS, Park K, Choi YL, Han J, Park W, Ahn MJ.
Two Cases of Small Cell Lung Cancer Transformation from EGFR Mutant Adenocarcinoma During AZD9291 Treatment, Journal of thoracic oncology, 2016 Jan;11(1):e1-4. doi: 10.1016/j.jtho.2015.09.013.

29. Kang G, Yun H, Sun CH, Park I, Lee S, Kwon J, Do I, Hong ME, Vrancken MV, Lee J, Park JO, Cho J, Kim KM, Sohn TS.
Integrated genomic analyses identify frequent gene fusion events and VHL inactivation in gastrointestinal stromal tumors, Oncotarget,  2016 Feb 9;7(6):6538-51

30. Kong DS, Kim J, Lee IH, Kim ST, Seol HJ, Lee JI, Park WY, Ryu G, Wang Z, Ma'ayan A, Nam DH.
Integrative radiogenomic analysis for multicentric radiophenotype in glioblastoma, Oncotarget, 2016 Mar 8;7(10):11526-38. doi: 10.18632

31. Song HN, Jung KS, Yoo KH, Cho J, Lee JY, Lim SH, Kim HS, Sun JM, Lee SH, Ahn JS, Park K, Choi YL, Park W, Ahn MJ.
Acquired C797S Mutation upon Treatment with a T790M-Specific Third-Generation EGFR Inhibitor (HM61713) in Non-Small Cell Lung Cancer, Journal of thoracic oncology, 2016 Apr;11(4):e45-7. doi: 10.1016/j.jtho.2015.12.093

32. Lee H, Hwang SJ, Kim HR, Shin CH, Choi KH, Joung JG, Kim HH.
Neurofibromatosis 2 (NF2) controls the invasiveness of glioblastoma thorough YAP-dependent expression of CYR61/CCN1 and miR-296-3p, BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2016 Apr;1859(4):599-611

33. Kim SY, Kim AR, Kim NK, Lee C, Kim MY, Jeon EH, Park WY, Choi BY.
Unraveling of Enigmatic Hearing-Impaired GJB2 Single Heterozygotes by Massive Parallel Sequencing: DFNB1 or Not?, Medicine, 2016 Apr;95(14):e3029

34. Yang L, Lee MS, Lu H, Oh DY, Kim YJ, Park D, Park G, Ren X, Bristow CA, Haseley PS, Lee S, Pantazi A, Kucherlapati R, Park WY, Scott K, Choi YL, Park PJ.
Analysis of somatic genome rearrangements in human cancers by whole exome sequencing, American Journal of Human Genetics, 2016 May 5;98(5):843-856

35. Ra EA, LeeTA, Won Kim S, Park A, Choi HJ, Jang I, Kang S, Hee Cheon J, cho JW, Eun Lee J , Lee S , Park  B.
TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells, Nature Communications, 2016 May 24;7:11726

36. Kim HK, Kim SY, Lee SJ, Kang M, Kim ST, Jang J, Rath O, Schueler J, Lee DW, Park WY, Kim SJ, Park SH, Lee J.
BEZ235 (PIK3/mTOR inhibitor) Overcomes Pazopanib Resistance in Patient-Derived Refractory Soft Tissue Sarcoma Cells, Translational Oncology, 2016 Jun;9(3):197-202. doi: 10.1016/j.tranon.2016.03.008

37. Kim JH, Son KY, Shin DW, Kim SH, Yun JW, Shin JH, Kang MS, Chung EH, Yoo KH, Yun JM.
Network analysis of human diseases using Korean nationwide claims data, Journal of Biomedical Informatics, 2016 Jun;61-276-82

38. Hwang JY, Lee J, Oh CK, Kang HW, Hwang IY, Um JW, Park HC, Kim S, Shin JH, Park WY, Darnell RB, Um HD, Chung KC, Kim K, Oh YJ.
Proteolytic degradation and potential role of onconeural protein cdr2 in neurodegeneration, CELL DEATH & DISEASE, 2016 Jun 2;7(6):e2240

39. Kim JH, Ki SM, Joung JG, Scott E, Heynen-Genel S, Aza-Blanc P, Kwon CH, Kim J, Gleeson JG, Lee JE.
Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2016 Jun; 1863(6 Pt A):1307-18.

40. Ahn S, Hwang SH, Han J, Choi YL, Lee SH, Ahn JS, Park K, Ahn MJ, Park WY.
Transformation to Small-Cell Lung Cancer of Pulmonary Adenocarcinoma- Clinicopathologic analysis of six cases, Journal of Pathology and Translational Medicine, 2016 Jul; 50(4): 258–263.

41. Wang J, Cazzato E, Ladewig E, Frattini V, Rosenbloom DI, Zairis S, Abate F, Liu Z, Elliott O, Shin YJ, Lee JK, Lee IH, Park WY, Eoli M, Blumberg AJ, Lasorella A, Nam DH, Finocchiaro G, Iavarone A, Rabadan R.
Clonal evolution of glioblastoma under therapy, Nature Genetics, 2016 Jul;48(7):768-76

42. Kim TH, Kim YE, Ahn S, Kim JY, Ki CS, Oh YL, Kim K, Yun JW, Park WY, Kim SW, Chung JH.
TERT promoter mutations and long-term survival in patients with thyroid cancer, ENDOCRINE-RELATED CANCER, 2016 Oct;23(10):813-23

43. Chai-Jin Lee, Hongryul Ahn, Sean Bong Lee, Jong-Yeon Shin, Woong-Yang Park, Jong-Il Kim, Junghee Lee, Hoon RyuEmail author and Sun Kim.
Integrated analysis of omics data using microRNA-target mRNA network and PPI network revealsregulation of Gnai1 function in the spinal cord of Ews/Ewsr1 KO mice, BMC Medical Genomics, 2016 Aug 12;9 Suppl 1:33

44. Lee NH, Choi YB, Yi ES, Lee SH, Kim HJ, Lee JW, Sung KW, Koo HH, Yoo KH.
Monosomal karyotype is not a predictor of dismal outcome in childhood de novo acute myeloid leukemia, LEUKEMIA RESEARCH, Leuk Res. 2016 Sep 15;50:57-62.

45. SooJin Kwon , Soo Mi Ki , Sang Eon Park , Min-Jeong Kim , Brian Hyung ,Na Kyung Lee , Sangmi Shim , Byung-Ok Choi , Duk L Na , Ji Eun Lee & Jong Wook Chang.
Anti-apoptotic effects of human wharton's jelly-derived mesenchymal stem cells on skeletal muscle cells mediated via secretion of XCL1, Molecular Therapy, 2016 Sep; 24(9):1550-60

46. Mi-Sun Kwon, Jaewon Min, Hee-Yeon Jeon, Kwangwoo Hwang, Chuna Kim, Junho Lee, Je-Gun Joung, Woong-Yang Park, and Hyunsook Lee.
Paradoxical delay of senescence upon depletion of BRCA2 in telomerasedeficient worms, FEBS Open Bio, 2016 Sep7; 6(10):1016-1024

47. Kim BJ, Kim AR, Lee C, Kim SY, Kim NK, Chang MY, Rhee J, Park MH, Koo SK, Kim MY, Han JH, Oh SH, Park WY, Choi BY.
Discovery of CDH23 as a significant contrubutor to progressive postlingual sensorineural hearing loss in Koreans, PLoS One, 2016 Oct 28;11(10):e0165680.

48. Kim SY, Kim AR, Kim NK, Lee C, Han JH, Kim MY, Jeon EH, Park WY, Mittal R, Yan D, Liu XZ, Choi BY.
Functional Characterization of a novel loss-of-function mutation of PRPS1 related to early-onset progressive nonsyndromic hearing loss in Koreans(DFNX1): Potential implications on future therapeutic intervention, Journal of gene medicine, 2016 Nov;18(11-12):353-358

49. Hongseok Shim, Ji Hyun Kim, Chan Yeong Kim, Sohyun Hwang, Hyojin Kim, Sunmo Yang, Ji Eun Lee, and Insuk Lee.
Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource, Nucleic Acids Research, 2016 Nov 16;44(20):9611-9623.

50. Kim B, Lee B, Kim MK, Gong SP, Park NH, Chung HH, Kim HS, No JH, Park WY, Park AK, Lim JM, Song YS.
Gene expression profiles of human subcutaneous and visceral, CELL BIOCHEMISTRY AND FUNCTION, 2016 Dec;34(8):563-57

51. Kim HK, Lee S, Kim K, Heo MH, Lee H, Cho J, Kim NK, Park W, Lee SJ, Kim JH, Jang KT, Choi SH, Lee.
Efficacy of BRAF inhibitors in asian metastatic melanoma patients: potential implications of genomic sequencing in BRAF-mutated melanoma, Translational Oncology, 2016 Dec;9(6):557-564

52. Huh HD, Ra EA, Lee TA, Kang S, Park A, Lee E, Choi JL, Jang E, Lee JE, Lee S, Park B.
STRAP acts as a scaffolding proteuin in controlling the TLR2/4 signaling pathway, Scientific Reports, 2016 Dec 9;6:38849

53. Sung Hee Lim, Sun-Young Kim, Kyung Kim, Hyojin Jang, Soomin Ahn, Kyoung-Mee Kim, Nayoung K.D. Kim, Woongyang Park, Su Jin Lee, Seung Tae Kim, Se Hoon Park, Joon Oh Park, Young Suk Park, Se-Hoon Lee, Ho Yeong Lim, Keunchil Park, Won Ki Kang, Jeeyun Lee.
The implication of FLT3 amplification for FLT targeted therapeutics in solid tumors, Oncotarget, 2016 Nov 29. doi:10.18632

54. Kim ST, Kim SY, Klempner SJ, YoonJ, Kim N, Ahn S, Bang H, Kim KM, Park W, Park SH, Park JO, Park YS, LimHY, Lee SH, Park K, Kang WK, Lee J.
Rapamycin-insensitive companion of mTOR(RICTOR) amplification defines a subset of advanced gastric cancer and is sensitive to AZD2014-mediated mTORC1/2 inhibition, Annals of oncology, 2016 Dec27.