삼성서울병원

Ko En

신장내과 김윤구 교수

진료분야
사구체 신질환
진료일정 08 月
날짜
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오전
오후
진료일정 09 月
날짜
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학력

학력
1993.02 서울대학교 대학원 의학박사
1989.02 서울대학교 대학원 의학석사
1983.02 서울대학교 의과대학 의학과

경력

경력
2002.03 ~현재 성균관의대 내과학 교수
1994.04 ~현재 삼성서울병원 신장내과 전문의
2009.09 ~ 2013.07 삼성서울병원 신장내과 과장
1997.03 ~ 2002.02 성균관의대 내과학 부교수
1997.08 ~ 1999.07 미국 워싱톤 의과대학 신장내과 교환 교수
1993.02 ~ 1994.03 보라매 병원 신장내과
1991.03 ~ 1993.02 지방공사 강남병원 신장내과
1990.03 ~ 1991.02 서울대학교병원 신장내과 전임의
1987.02 ~ 1990.02 서울대학교병원 내과 레지던트
1986.05 ~ 1987.02 서울대학교병원 인턴

연구분야

연구분야
신손상 진행 에방과 치료를 위한 줄기 세포 치료법 개발
신손상은 급성 신손상과 만성 신손상으로 구분할 수 있으며 두 경우에서 모두 신손상이 지속될 경우 신장 기능은 회복되지 못하고 투석이나 이식이 필요한 만성신부전증으로 진행하게 된다. 신손상 진행을 막기 위해서는 식이 요법, 약물 요법 (고혈압, 고지혈증, 고혈당 치료제)과 같은 보존적 치료를 기본으로 하여 면역기전(주로 자가면역 손상)에 의한 신손상인 경우에는 면역억제 치료를 병행하기도 한다. 하지만 아직도 많은 경우에서 신손상 진행을 완벽하게 막지 못해서 결국 만성신부전증으로 진행하는 것이 현 실정이다. 줄기 세포 치료 (mesenchymal stem cell)는 동물 실험에서 급성신손상 (허혈성, 신독성) 에방과 치료 효과는 알려지고 있으나 아직 용량, 투여 경로, 부작용에 대해 논란이 많으며 만성 신손상의 경우에는 아직 동물 실험 결과도 미미한 실정이라 실제 환자에서 임상 치료로 적용되지 못하고 있다. 연구자는 본원 신장내과 이정은, 장혜련 교수와 한팀으로 현재 급성신손상, 만성신손상 동물 모델에서 중간엽 줄기세포 치료 효과와 치료 기전을 연구 중이며 향후 임상 적용이 빠른 시간내에 될 수 있도록 최선을 다하고 있다.
  • FRONT IMMUNOL 2021 10.3389/fimmu.2021.621176 Dietary Modification Alters the Intrarenal Immunologic Micromilieu and Susceptibility to Ischemic Acute Kidney Injury Jeon1, J; Lee, K; Yang, KE; Lee, JE; Kwon, GY; Huh, W; Kim, DJ; Kim, YG; Jang, HR
    View PubMed
  • BLOOD PURIFICAT 2021 10.1159/000512350 A Scoring Model with Simple Clinical Parameters to Predict Successful Discontinuation of Continuous Renal Replacement Therapy Baeg1, SI; Jeon, J; Yoo, H; Na, SJ; Kim, K; Chung, CR; Yang, JH; Jeon, K; Lee, JE; Huh, W; Suh, GY; Kim, YG; Kim, DJ; Jang, HR
    View PubMed
  • J AM SOC NEPHROL 2021 10.1681/ASN.2019050546 Comparison of the Efficacy and Safety of Tacrolimus and Low-Dose Corticosteroid with High-Dose Corticosteroid for Minimal Change Nephrotic Syndrome in Adults Chin1, HJ; Chae, DW; Kim, YC; An, WS; Ihm, C; Jin, DC; Kim, SG; Kim, YL; Kim, YS; Kim, YG; Koo, HS; Lee, JE; Lee, KW; Oh, J; Park, JH; Jiang, HS; Lee, H; Lee, SK
    View PubMed
  • FRONT CELL DEV BIOL 2021 10.3389/fcell.2020.618796 Modeling Uremic Vasculopathy With Induced Pluripotent Stem Cell-Derived Endothelial Cells as a Drug Screening System Jang1, HR; Cho, HJ; Zhou, Y; Shao, NY; Lee, K; Le, HHT; Jeon, J; Lee, JE; Huh, W; Ong, SG; Lee, WH; Kim, YG
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  • RENAL FAILURE 2021 10.1080/0886022X.2021.1940202 Predialysis predictors for identifying patients requiring dialysis at a higher glomerular filtration rate Jeon1, J; Jang, HR; Huh, W; Kim, YG; Kim, DJ; Lee, JE
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  • FRONT IMMUNOL 2020 10.3389/fimmu.2020.564288 Poly (ADP-Ribose) Polymerase Inhibitor Treatment as a Novel Therapy Attenuating Renal Ischemia-Reperfusion Injury Jang1, HR; Lee, K; Jeon, J; Kim, JR; Lee, JE; Kwon, GY; Kim, YG; Kim, DJ; Ko, JW; Huh, W
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  • BMC NEPHROLOGY 2020 10.1186/s12882-020-01825-6 Urinary angiotensinogen as a surrogate marker predicting the antiproteinuric effects of angiotensin receptor blockers in patients with overt proteinuria: a multicenter prospective study Jeon1, J; Kim, DH; Jang, HR; Lee, JE; Huh, W; Kim, HY; Kim, DJ; Kim, YG
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  • BMC NEPHROLOGY 2019 10.1186/s12882-019-1403-1 Creatinine- and cystatin C-based estimated glomerular filtration rate slopes for the prediction of kidney outcome: a comparative retrospective study Kim1, S; Hwang, S; Jang, HR; Sohn, I; Ahn, HS; Park, HD; Huh, W; Jin, DC; Kim, YG; Kim, DJ; Oh, HY; Lee, JE
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  • J ONCOL 2019 10.1155/2019/8736163 Risk Prediction for Contrast-Induced Nephropathy in Cancer Patients Undergoing Computed Tomography under Preventive Measures Jeon1, J; Kim, S; Yoo, H; Kim, K; Kim, Y; Park, S; Jang, HR; Kim, DK; Huh, W; Kim, YG; Kim, DJ; Oh, HY; Lee, JE
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  • TRANSPL P 2019 10.1016/j.transproceed.2018.10.026 Clinical Impact of a Protocolized Kidney Donor Follow-up System Kwon1, HJ; Jeon, J; Kim, DH; Jang, HR; Sung, HH; Han, DH; Park, JB; Lee, JE; Huh, W; Kim, SJ; Kim, YG; Kim, DJ; Oh, HY
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  • VASCULAR 2019 10.1177/1708538118807844 Arteriovenous graft patency outcomes and prognostic factors Park1, J; Kim, J; Hwang, S; Lee, MK; Jang, HR; Eun Lee, J; Park, YJ; Huh, W; Kim, YG; Oh, HY; Kim, DJ
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  • CRIT CARE 2018 10.1186/s13054-018-2192-9 Association between diuretics and successful discontinuation of continuous renal replacement therapy in critically ill patients with acute kidney injury Jeon1, J; Kim, DH; Baeg, SI; Lee, EJ; Chung, CR; Jeon, K; Lee, JE; Huh, W; Suh, GY; Kim, YG; Kim, DJ; Oh, HY; Jang, HR
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  • EUR J CLIN INVEST 2018 10.1111/eci.12936 First-year GFR slope and long-term renal outcome in IgA nephropathy Lee1, K; Shin, J; Park, J; Hwang, S; Jang, HR; Huh, W; Kwon, GY; Kim, YG; Oh, HY; Lee, JE; Kim, DJ
    View PubMed
  • J DIABETES COMPLICAT 2017 10.1016/j.jdiacomp.2017.08.009 Tissue expression of tubular injury markers is associated with renal function decline in diabetic nephropathy Hwang1, S; Park, J; Kim, J; Jang, HR; Kwon, GY; Huh, W; Kim, YG; Kim, DJ; Oh, HY; Lee, JE
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  • TRANSPL P 2017 10.1016/j.transproceed.2017.09.024 Predictive Factors of Renal Adaptation After Nephrectomy in Kidney Donors Kwon1, HJ; Kim, DH; Jang, HR; Jung, SH; Han, DH; Sung, HH; Park, JB; Lee, JE; Huh, W; Kim, SJ; Kim, YG; Kim, DJ; Oh, HY
    View PubMed
  • J CLIN SLEEP MED 2017 10.5664/jcsm.6758 Independent Contributions of Obstructive Sleep Apnea and the Metabolic Syndrome to the Risk of Chronic Kidney Disease Lee1, YJ; Jang, HR; Huh, W; Kim, YG; Kim, DJ; Oh, HY; Joo, EY; Lee, JE
    View PubMed
  • AM J PHYSIOL RENAL RHYSIOL 2017 10.1152/ajprenal.00097.2016 Early, but not late, treatment with human umbilical cord blood-derived mesenchymal stem cells attenuates cisplatin nephrotoxicity through immunomodulation Park1, JH; Jang, HR; Kim, DH; Kwon, GY; Lee, JE; Huh, W; Choi, SJ; Oh, W; Oh, HY; Kim, YG
    View PubMed
  • Eur J Intern Med. 2016 Sep;33:88-92. doi: 10.1016/j.ejim.2016.06.028. Epub 2016 Jul 12. Diagnostic performances of M-protein tests according to the clinical presentations of kidney disease Koo EH11, Shin JH1, Jang HR1, Park HD2, Kwon GY3, Huh W1, Kim DJ1, Kim YG1, Oh HY1, Lee JE4.
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  • Medicine (Baltimore). 2016 Jul;95(27):e3930. Risk factors for renal impairment revealed after unilateral adrenalectomy in patients with primary aldosteronism Kim DH11, Kwon HJ, Ji SA, Jang HR, Jung SH, Kim JH, Kim JH, Lee JE, Huh W, Kim YG, Kim DJ, Oh HY.
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  • Ann Med. 2016;48(3):171-81. doi: 10.3109/07853890.2016.1153805. Epub 2016 Mar 26. The effects of cytotoxic therapy in progressive IgA nephropathy Shin JH11, Lee JE1, Park JH1, Lim S2, Jang HR1, Kwon GY2, Huh W1, Jung SH3, Kim YG1, Oh HY1, Kim DJ1.
    View PubMed
  • Int Urol Nephrol. 2016 Mar;48(3):431-9. doi: 10.1007/s11255-015-1163-1. Epub 2015 Nov 18. The impact of slow graft function on graft outcome is comparable to delayed graft function in deceased donor kidney transplantation Shin JH11, Koo EH2, Ha SH3, Park JH2, Jang HR2, Lee JE2, Park JB4, Kim SJ4, Jung SH5, Kim YG2, Kim DJ2, Oh HY2, Huh W6.
    View PubMed
  • Am J Physiol Renal Physiol. 2016 Feb 15;310(4):F272-83. doi: 10.1152/ajprenal.00217.2015. Epub 2015 Dec 9. Aging has small effects on initial ischemic acute kidney injury development despite changing intrarenal immunologic micromilieu in mice Jang HR11, Park JH1, Kwon GY2, Park JB3, Lee JE1, Kim DJ1, Kim YG1, Kim SJ3, Oh HY1, Huh W4.
    View PubMed
  • Medicine (Baltimore). 2016 Jan;95(1):e2400. doi: 10.1097/MD.0000000000002400. Risk Factors for Renal Functional Decline in Chronic Hepatitis B Patients Receiving Oral Antiviral Agents Shin JH11, Kwon HJ, Jang HR, Lee JE, Gwak GY, Huh W, Jung SH, Lee JH, Kim YG, Kim DJ, Oh HY.
    View PubMed
  • Nephrology (Carlton). 2015 Apr;20(4):279-85. doi: 10.1111/nep.12383. Comparison of intrarenal renin-angiotensin system activity in diabetic versus non-diabetic patients with overt proteinuria Park JH11, Jang HR, Lee JH, Lee JE, Huh W, Lee KB, Kwon YJ, Do JY, Kim HY, Kim YG.
    View PubMed
  • Intern Med J. 2014 Dec;44(12a):1217-22. doi: 10.1111/imj.12591. Association between pre-donation serum uric acid concentration and change in renal function after living kidney donation in women Cho A11, Lee JE, Jang HR, Huh W, Kim DJ, Oh HY, Kim YG.
    View PubMed
  • BMC Cancer. 2014 Dec 3;14:906. doi: 10.1186/1471-2407-14-906. Increased risk of everolimus-associated acute kidney injury in cancer patients with impaired kidney function Ha SH1, Park JH, Jang HR, Huh W, Lim HY, Kim YG, Kim DJ, Oh HY, Lee JE1.
    View PubMed
  • Transplant Proc. 2014 Dec;46(10):3396-9. doi: 10.1016/j.transproceed.2014.04.015. Comparison of Cadaveric Kidney Transplantation From In-center and External Center Donors Cho AJ11, Jang HR2, Lee JE2, Huh WS2, Kim YG2, Oh HY2, Kim DJ3.
    View PubMed
  • Drug Des Devel Ther. 2014 Nov 7;8:2241-9. doi: 10.2147/DDDT.S70595. eCollection 2014. Early non-steady-state population pharmacokinetics of oral cyclosporine in renal transplant recipients Baek H11, Han S2, Yim DS2, Kim SJ3, Lee SY4, Jang HR5, Lee JE5, Kim DJ5, Kim YG5, Oh HY5, Huh W5.
    View PubMed
  • Transl Res.?2014 Nov;164(5):400-10. doi: 10.1016/j.trsl.2014.05.009. Epub 2014 May 23. Clinical relevance of urinary angiotensinogen and renin as potential biomarkers in patients with overt proteinuria Jang HR11,?Jeon J1,?Park JH1,?Lee JE1,?Huh W1,?Oh HY1,?Kim YG2.
    View PubMed
  • Am J Physiol?Renal?Physiol.?2014 Nov 15;307(10):F1149-61. doi: 10.1152/ajprenal.00555.2013. Epub 2014 Aug 20. Effect of preemptive treatment with human umbilical cord blood-derived mesenchymal stem cells on the development of renal ischemia-reperfusion injury in mice Jang HR11,?Park JH1,?Kwon GY2,?Lee JE1,?Huh W1,?Jin HJ3,?Choi SJ3,?Oh W3,?Oh HY1,?Kim YG4.
    View PubMed
  • Crit Care. 2014 Nov 19;18(6):640. doi: 10.1186/s13054-014-0640-8. Clinical relevance of procalcitonin and C-reactive protein as infection markers in renal impairment: a cross-sectional study Park JH11, Kim do H2, Jang HR3, Kim MJ4, Jung SH5, Lee JE6, Huh W7, Kim YG8, Kim DJ9, Oh HY10.
    View PubMed
  • Clin Transplant. 2014 Sep;28(9):953-60. doi: 10.1111/ctr.12388. Epub 2014 Jul 16. Impact of donor kidney function and donor age on poor outcome of living-unrelated kidney transplantation (KT) in comparison with living-related KT Park KS11, Shin JH, Jang HR, Lee JE, Huh WS, Kim YG, Oh HY, Kim DJ.
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  • JOURNAL OF NEUROSURGERY, JUN 2014, 120(6):1340-1348, 10.3171/2013.12.JNS13888 Increased risk of acute kidney injury associated with higher infusion rate of mannitol in patients with intracranial hemorrhage Clinical article Kim MY1, Park JH, Kang NR, Jang HR, Lee JE, Huh W, Kim YG, Kim DJ, Hong SC, Kim JS
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  • Can J Infect Dis Med Microbiol. 2012 Fall;23(3):e67-8. Infective endocarditis with multiple mycotic aneurysms mimicking vasculitis: A case report Park JH11, Jang HR, Lee JE, Huh W, Kim DJ, Oh HY, Kim YG.
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  • Ann Med.?2012 Aug;44(5):448-57. doi: 10.3109/07853890.2011.558518. Epub 2011 Mar 3. The origin and the clinical significance of urinary angiotensinogen in proteinuric IgA nephropathy patients Jang HR11,?Kim SM,?Lee YJ,?Lee JE,?Huh W,?Kim DJ,?Oh HY,?Kim YG.
    View PubMed
  • Postgrad Med J.?2012 Apr;88(1038):210-6. doi: 10.1136/postgradmedj-2011-130441. Epub 2012 Feb 22. Potential role of urinary angiotensinogen in predicting antiproteinuric effects of angiotensin receptor blocker in non-diabetic chronic kidney disease patients: a preliminary report Jang HR11,?Lee YJ,?Kim SR,?Kim SG,?Jang EH,?Lee JE,?Huh W,?Kim YG.
    View PubMed
  • Postgrad Med J. 2011 Oct;87(1032):664-9. doi: 10.1136/pgmj.2011.118059. Epub 2011 Jun 29. Effect of losartan on proteinuria and urinary angiotensinogen excretion in non-diabetic patients with chronic kidney disease Lee YJ11, Cho S, Kim SR, Jang HR, Lee JE, Huh W, Kim DJ, Oh HY, Kim YG.
    View PubMed
  • Clin Nephrol. 2011 Aug;76(2):117-23. Urinary angiotensinogen levels reflect the severity of renal histopathology in patients with chronic kidney disease Kim SM11, Jang HR, Lee YJ, Lee JE, Huh WS, Kim DJ, Oh HY, Kim YG.
    View PubMed
  • Nephrology (Carlton). 2011 Jul;16(5):502-10. doi: 10.1111/j.1440-1797.2011.01448.x. Renoprotective efficacy of valsartan in chronic non-diabetic proteinuric nephropathies with renin-angiotensin system gene polymorphisms Lee YJ11, Jang HR, Kim SG, Chae DW, Do JY, Lee JE, Huh W, Kim DJ, Oh HY, Kim YG.
    View PubMed
  • Hepatogastroenterology. 2011 Jul-Aug;58(109):1291-5. doi: 10.5754/hge07389. Clinical Impact of the Development of YMDD Mutants in Hepatitis B Virus-Associated Glomerulonephritis Gwak GY11, Lee CY, Lee DH, Huh W, Koh KC, Kim YG.
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  • Clin Nephrol.?2011 Jun;75(6):511-7. Combination treatment with corticosteroid, cyclosporine A, and mycophenolate in refractory nephrotic syndrome Jang HR11,?Jung HW,?Lee YJ,?Lee JE,?Huh W,?Kim DJ,?Oh HY,?Kim YG.
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  • J Korean Med Sci. 2009 Jan;24 Suppl:S176-82. doi: 10.3346/jkms.2009.24.S1.S176. Epub 2009 Jan 29. Hypoxia Induces Connective Tissue Growth Factor mRNA Expression Lee YK11, Kim EJ, Lee JE, Noh JW, Kim YG.
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  • J Korean Med Sci. 2009 Jan;24 Suppl:S22-9. doi: 10.3346/jkms.2009.24.S1.S22. Epub 2009 Jan 28. The Mildly Elevated Serum Bilirubin Level is Negatively Associated with the Incidence of End Stage Renal Disease in Patients with IgA Nephropathy Chin HJ11, Cho HJ, Lee TW, Na KY, Oh KH, Joo KW, Yoon HJ, Kim YS, Ahn C, Han JS, Kim S, Jeon ES, Jin DC, Kim YL, Park SH, Kim CD, Song YR, Kim SG, Kim YG, Lee JE, Oh YK, Lim CS, Lee SK, Chae DW, Cho WY, Kim HK, Jo SK; Progressive REnal disease and Medical Informatics and gEnomics Research (PREMIER) members.
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  • J Korean Med Sci. 2009 Jan;24 Suppl:S63-8. doi: 10.3346/jkms.2009.24.S1.S63. Epub 2009 Jan 28. N-terminal Pro-Brain Natriuretic Peptide Levels Predict Left Ventricular Systolic Function in Patients with Chronic Kidney Disease Lee JE11, Choi SY, Huh W, Park SW, Kim DJ, Oh HY, Kim YG.
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  • Nephron Clin Pract. 2008;110(2):c93-100. doi: 10.1159/000157622. Epub 2008 Sep 25. Association between Changes in N-Terminal Pro-Brain Natriuretic Peptide Levels and Changes in Left Ventricular Mass Index in Stable Hemodialysis Patients Choi SY11, Lee JE, Jang EH, Kim MO, Baek H, Ki CS, Park SW, Kim DJ, Huh WS, Oh HY, Kim YG.
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  • Nephron Clin Pract. 2004;97(1):c5-10. Hemodialysis using heparin-bound hemophan in patients at risk of bleeding Lee KB11, Kim B, Lee YH, Yoon SJ, Kang WH, Huh W, Kim DJ, Oh HY, Kim YG.
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  • Nephrology (Carlton). 2003 Oct;8 Suppl:S23-7. Anticoagulation during haemodialysis in patients at high-risk of bleeding 1,Kim YG1.
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  • Nephrol Dial Transplant. 2001 Dec;16(12):2303-9. Medullary nephrocalcinosis associated with long-term furosemide abuse in adults Kim YG11, Kim B, Kim MK, Chung SJ, Han HJ, Ryu JA, Lee YH, Lee KB, Lee JY, Huh W, Oh HY.
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  • Am J Physiol Renal Physiol. 2001 Oct;281(4):F620-9. Hypokalemia induces renal injury and alterations in vasoactive mediators that favor salt sensitivity Suga SI11, Phillips MI, Ray PE, Raleigh JA, Vio CP, Kim YG, Mazzali M, Gordon KL, Hughes J, Johnson RJ.
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  • Kidney Int. 2001 Oct;60(4):1297-308. Vascular endothelial growth factor (VEGF(121)) protects rats from renal infarction in thrombotic microangiopathy Suga S11, Kim YG, Joly A, Puchacz E, Kang DH, Jefferson JA, Abraham JA, Hughes J, Johnson RJ, Schreiner GF.
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  • Kidney Int. 2001 Sep;60(3):1018-25. Intravenous immunoglobulin protects against experimental thrombotic microangiopathy Jefferson JA11, Suga SI, Kim YG, Pippin J, Gordon KL, Johnson RJ, Couser WG.
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  • Transplantation. 2001 Apr 15;71(7):900-5. Hyperuricemia exacerbates chronic cyclosporine nephropathy Mazzali M11, Kim YG, Suga S, Gordon KL, Kang DH, Jefferson JA, Hughes J, Kivlighn SD, Lan HY, Johnson RJ.
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  • Am J Physiol Renal Physiol. 2001 Apr;280(4):F727-36. Post-cyclosporine-mediated hypertension and nephropathy: amelioration by vascular endothelial growth factor Kang DH11, Kim YG, Andoh TF, Gordon KL, Suga S, Mazzali M, Jefferson JA, Hughes J, Bennett W, Schreiner GF, Johnson RJ.
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  • Kidney Int. 2000 Dec;58(6):2390-9. Vascular endothelial growth factor accelerates renal recovery in experimental thrombotic microangiopathy Kim YG11, Suga SI, Kang DH, Jefferson JA, Mazzali M, Gordon KL, Matsui K, Breiteneder-Geleff S, Shankland SJ, Hughes J, Kerjaschki D, Schreiner GF, Johnson RJ.
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  • Mol Med. 2000 Oct;6(10):837-48. Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathy Kim YG11, Huang XR, Suga S, Mazzali M, Tang D, Metz C, Bucala R, Kivlighn S, Johnson RJ, Lan HY.
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