삼성서울병원

Ko En

신경외과 남도현 교수

진료분야
뇌하수체종양, 뇌교종, 전이성뇌종양, 악성뇌종양
진료일정 12 月
날짜
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31
오전
오후
진료일정 01 月
날짜
01
02
03
04
05
06
07
08
09
10
11
12
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15
16
17
18
19
20
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오전
오후

학력

학력
2001.02 서울대학교 대학원 의학과 (박사)
1997.02 서울대학교 대학원 의학과 (석사)
1988.02 서울대학교 의과대학 졸업 (의학사)

경력

경력
2009.12 ~현재 삼성 난치암 연구사업단 단장
2009.04 ~현재 성균관의대 신경외과학교실 교수
1998.03 ~현재 삼성서울병원 신경외과 전문의
2013.03 ~ 2017.02 삼성 융합의과학과 과장
2003.04 ~ 2009.03 성균관의대 신경외과학교실 부교수
2002.02 ~ 2004.01 미국 Univ. of Texas MD Anderson Cancer Center 연구원
1999.03 ~ 2003.03 성균관의대 신경외과학교실 조교수
1997.03 ~ 1998.02 삼성서울병원 신경외과 전임의
1996.05 ~ 1997.02 서울대학병원 신경외과 전임의
1989.03 ~ 1993.02 서울대학교병원 신경외과 레지던트 과정 수료
1988.03 ~ 1989.02 서울대학교병원 인턴 과정 수료

연구분야

연구분야
뇌종양 개인 맞춤 치료(아바타) 및 유전체 연구
본 연구실은 암환자에게 최적의 치료 솔루션을 제시할 수 있는 개인 맞춤 의학 실현을 위해 환자와 유전체 정보 및 약물정보를 연결해주는 인터페이스 개발을 목표로 연구하고 있다. 이를 위하여 암줄기세포를 표적으로 하여 특정 신호전달체계와 유전자 발현의 특성에 대한 연구를 진행하고 있으며, 특히 교모세포종 환자로부터 암줄기세포를 분리하여 배양하는 방법을 국내 최초로 확립하였다. 환자 유래 샘플 라이브러리를 통한 아바타 모델을 확립하여 유전체 기반 개인 맞춤 치료 플랫폼을 구축하였고 암 환자에게 최적의 치료 솔루션을 제공할 수 있는 인터페이스 역할인 아바타 스캔 시스템을 개발 중이다.
뇌하수체 종양 내시경 수술기법 연구
뇌하수체 종양은 전체 뇌종양의 10~15%의 빈도를 차지하고 있는 질환으로, 해부학적 위치의 특성상 두개절개술로 접근하기에 여러 가지 어려움이 있습니다. 이에 대한 수술적 접근을 위해 경접형동 접근법(Trans-sphenoidal approach)를 통한 현미경적 수술이 과거부터 사용되어 왔으나, 수술시야에서 한계가 많아 적용범위가 제한적이었습니다. 최근 장비의 발전과 여러 수술법의 개발로 내시경을 이용한 경접형동 접근법 수술이 증가하는 추세이며, 이 방법을 이용하여 뇌하수체 선종 뿐 아니라 두개인두종, 척삭종 및 터키안결절 부위에서 발생한 뇌수종까지 적용범위가 늘어나고 있습니다. 그러나 내시경을 이용한 경접형동 접근법 수술법을 시행하게 되면 현미경적 수술법에 비해 코점막의 손상이 크고 수술 후 후각기능의 저하가 심하다는 것과 뇌척수액 누출의 위험성이 상대적으로 높다는 치명적인 단점이 있습니다. 이에 이비인후과와 협진하여 코점막의 손상을 최소화하면서도 안전하고 효과적인 내시경 수술기법을 시행하기 위한 여러 가지 연구를 진행하고 있습니다.
  • CLIN TRANSL RAD ONCO 2024 10.1016/j.ctro.2024.100799 Nomogram for radiation-induced lymphopenia in patients receiving intensity-modulated radiotherapy based-chemoradiation therapy for newly diagnosed glioblastoma: A multi-institutional study Kim, N; Lee, J; Shin, H; Shin, J; Nam, D; Lee, JI; Seol, HJ; Kong, DS; Choi, JW; Chong, K; Lee, WJ; Chang, JH; Kang, SG; Moon, JH; Cho, JH; Lim, DH; Yoon, HI
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  • NAT CELL BIOL 2024 10.1038/s41556-024-01428-5 Tumour microenvironment programming by an RNA-RNA-binding protein complex creates a druggable vulnerability in IDH-wild-type glioblastoma Wu, LL; Zhao, Z; Shin, YJ; Yin, YY; Raju, A; Vaiyapuri, TS; Idzham, K; Son, M; Lee, YR; Sa, JK; Chua, JYH; Unal, B; Zhai, Y; Fan, WH; Huang, LJ; Hu, HM; Gunaratne, J; Nam, D; Jiang, T; Tergaonkar, V
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  • ENDOCRINOL METAB 2024 10.3803/EnM.2023.1877 Clinical Characteristics, Diagnosis, and Treatment of Thyroid Stimulating Hormone-Secreting Pituitary Neuroendocrine Tumor (TSH PitNET): A Single-Center Experience Heo, J; Suh, YL; Kim, SH; Kong, DS; Nam, D; Lee, WJ; Kim, ST; Hong, SD; Ryu, S; Lee, YB; Kim, G; Jin, SM; Kim, JH; Hur, KY
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  • CANCER CELL 2024 10.1016/j.ccell.2023.12.015 Integrated proteogenomic characterization of glioblastoma evolution Kim, KH; Migliozzi, S; Koo, H; Hong, JH; Park, SM; Kim, S; Kwon, HJ; Ha, S; Garofano, L; Oh, YT; D'Angelo, F; Il Kim, C; Kim, S; Lee, JY; Kim, J; Hong, JS; Jang, EH; Mathon, B; Di Stefano, AL; Bielle, F; Laurenge, A; Nesvizhskii, AI; Hur, EM; Yin, JL; Shi, BY; Kim, Y; Moon, KS; Kwon, JT; Lee, SH; Lee, SH; Gwak, HS; Lasorella, A; Yoo, H; Sanson, M; Sa, JK; Park, CK; Nam, D; Iavarone, A; Park, JB
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  • CANCERS 2024 10.3390/cancers16010064 Treatment Outcomes after Dose-Escalated Moderately Hypofractionated Radiotherapy for Frail Patients with High-Grade Glioma Kim, N; Shin, H; Lim, D; Nam, D; Lee, JI; Seol, HJ; Kong, DS; Choi, JW; Chong, KYH; Lee, WJ
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  • JCI INSIGHT 2023 10.1172/jci.insight.167049 The semaphorin 3A/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-β signaling Jeon, HM; Shin, YJ; Lee, J; Chang, N; Woo, DH; Lee, WJ; Nguyen, D; Kang, W; Cho, HJ; Yang, H; Lee, JK; Sa, JK; Lee, Y; Kim, DG; Purow, BW; Yoon, Y; Nam, D; Lee, JW
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  • J NEURO-ONCOL 2023 10.1007/s11060-023-04465-6 Impact of boost sequence in concurrent chemo-radiotherapy on newly diagnosed IDH-wildtype glioblastoma multiforme Kim, N; Lee, J; Nam, D; Lee, JI; Seol, HJ; Kong, DS; Choi, JW; Chong, K; Lee, WJ; Chang, JH; Kang, SG; Moon, JH; Cho, J; Lim, D; Yoon, HI
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  • SCI TRANSL MED 2023 10.1126/scitranslmed.adh4181 Identifying predictors of glioma evolution from longitudinal sequencing Mu, QH; Chai, RC; Pang, B; Yang, YX; Liu, HJ; Zhao, Z; Bao, ZS; Song, D; Zhu, ZH; Yan, ML; Jiang, BB; Mo, ZC; Tang, JH; Sa, JK; Cho, HJ; Chang, YZ; Chan, KHY; Loi, DSC; Tam, SST; Chan, AKY; Wu, AR; Liu, ZQ; Poon, WS; Ng, HK; Chan, DTM; Iavarone, A; Nam, D; Jiang, T; Wang, JG
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  • J KOREAN NEUROSURG S 2023 10.3340/jkns.2022.0229 Effect of Bevacizumab Treatment in Cerebral Radiation Necrosis : Investigation of Response Predictors in a Single-Center Experience Lee, SH; Choi, JW; Kong, DS; Seol, HJ; Nam, DH; Lee, JI
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  • CANCER MED-US 2023 10.1002/cam4.6213 A multicenter, phase II trial of GC1118, a novel anti-EGFR antibody, for recurrent glioblastoma patients with EGFR amplification Choi, SW; Jung, HA; Cho, HJ; Kim, TM; Park, CK; Nam, D; Lee, SH
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  • CANCER CELL 2023 10.1016/j.ccell.2023.06.007 Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling Jeon, HM; Kim, JY; Cho, HJ; Lee, WJ; Nguyen, D; Kim, SS; Oh, YT; Kim, HJ; Hubert, CG; Jung, CW; Pinero, G; Joshi, T; Sakaguchi, T; Hambardzumyan, D; Mcintyre, TM; Fine, HA; Gladson, CL; Wang, BC; Purow, BW; Park, JB; Park, MJ; Nam, D; Lee, J
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  • ADV THER-GERMANY 2023 10.1002/adtp.202300148 Translational mRNA Profiling Analysis of Pseudopalisading Cells in Bevacizumab Resistance of GBM Kim, Y; Kim, TH; Sreynet, S; Oh, YS; Nam, D; Park, JB; Kim, SS
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  • DISCOV ONCOL 2023 10.1007/s12672-023-00678-3 Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study) Yoon, WS; Chang, JH; Kim, JH; Kim, YJ; Jung, TY; Yoo, H; Kim, SH; Ko, YC; Nam, DH; Kim, TM; Kim, SH; Park, SH; Lee, YS; Yim, HW; Hong, YK; Yang, SH
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  • ADV THER-GERMANY 2023 10.1002/adtp.202300067 The Regulatory Roles of Mitochondrial Metabolism Dynamics and Mitochondria Calcium Uniporter (MCU) in Bevacizumab Resistance of GBM Kim, Y; Kwak, C; Park, JB; Nam, D; Rhee, HW; Kim, SS
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  • YONSEI MED J 2023 10.3349/ymj.2022.0352 Clinical Outcomes of Moderately Hypofractionated Concurrent Chemoradiotherapy for Newly Diagnosed Glioblastoma Kim, N; Lim, DH; Choi, JW; Lee, JI; Kong, DS; Nam, DH; Seol, HJ
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  • WORLD NEUROSURG 2022 10.1016/j.wneu.2022.10.067 Impact of Postural Changes on Sinonasal Pressure After Endoscopic Endonasal Surgery Choi, HW; Choi, JW; Seol, HJ; Nam, D; Lee, JI; Kong, DS
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  • J CLIN MED 2022 10.3390/jcm11226711 Comparison of Graft Materials in Multilayer Reconstruction with Nasoseptal Flap for High-Flow CSF Leak during Endoscopic Skull Base Surgery Kim, BK; Kong, DS; Nam, DH; Hong, SD
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  • WORLD NEUROSURG 2022 10.1016/J.WNEu.2022.04.088 Factors Associated with Acute Obstructive Hydrocephalus After Retrosigmoid Approach for Extra-Axial Cerebellopontine Angle Tumors Lee, WJ; Choi, JW; Kong, DS; Nam, D; Lee, JI; Seol, HJ
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  • BIOCHEM BIOPH RES CO 2022 10.1016/j.bbrc.2022.07.107 Functional validation of the simplified in vitro 3D Co-culture based BBB model Kim, W; Kim, J; Lee, SY; Kim, HM; Jung, HT; Joo, KM; Nam, D
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  • BIOCHEM BIOPH RES CO 2022 10.1016/j.bbrc.2022.06.083 Simplified in vitro 3D co-culture-based blood-brain barrier model using transwell Kim, W; Kim, J; Lee, SY; Kim, HM; Joo, KM; Nam, D
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  • ADV SCI 2022 10.1002/advs.202201785 Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co-Culture Chip Kim, H; Sa, JK; Kim, J; Cho, HJ; Oh, HJ; Choi, DH; Kong, SH; Jeong, D; Nam, DH; Lee, H; Lee, HW; Chung, S
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  • SCI REP-UK 2022 10.1038/s41598-022-13853-3 Clinical outcomes of patients with multiple courses of radiosurgery for brain metastases from non-small cell lung cancer Lee, WJ; Choi, JW; Kong, DS; Seol, HJ; Nam, DH; Lee, JI
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  • FRONT ONCOL 2022 10.3389/fonc.2022.906162 Clinical Impact of Hydroxyapatite on the Outcome of Skull Base Reconstruction for Intraoperative High-Flow CSF Leak: A Propensity Score Matching Analysis Lee, SH; Ha, CM; Hong, SD; Choi, JW; Seol, HJ; Nam, D; Lee, JI; Kong, DS
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  • CANCER RES TREAT 2022 10.4143/crt.2021.393 Influence of Concurrent and Adjuvant Temozolomide on Health-Related Quality of Life of Patients with Grade III Gliomas: A Secondary Analysis of a Randomized Clinical Trial (KNOG-1101 Study) Ahn, GS; Hwang, K; Kim, TM; Park, CK; Chang, JH; Jung, TY; Kim, JH; Nam, DH; Kim, SH; Yoo, H; Hong, YK; Kim, EY; Lee, DE; Joo, J; Kim, YJ; Choe, G; Choi, BS; Kang, SG; Kim, JH; Kim, CY
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  • ACTA NEUROCHIR 2022 10.1007/s00701-022-05203-z Combined endoscopic endonasal and transorbital multiportal approach for complex skull base lesions involving multiple compartments Lee, WJ; Hong, SD; Woo, KI; Seol, HJ; Choi, JW; Lee, JI; Nam, DH; Kong, DS
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  • WORLD NEUROSURG 2022 10.1016/j.wneu.2021.12.074 Serum Prolactin Level to Tumor Size Ratio as a Potential Parameter for Preoperative Differentiation of Prolactinomas from Hyperprolactinemia-Causing Non-functional Pituitary Adenomas Kim, JH; Hur, KY; Hong, SD; Choi, JW; Seol, HJ; Nam, DH; Lee, JI; Kong, DS
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  • WORLD NEUROSURG 2022 10.1016/j.wneu.2021.10.169 Treatment Strategy for Giant Solid Hemangioblastomas in the Posterior Fossa: A Retrospective Review of 13 Consecutive Cases Jeon, C; Choi, JW; Kong, DS; Nam, DH; Lee, JI; Seol, HJ
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  • SCI REP-UK 2022 10.1038/s41598-022-06881-6 Histopathology and surgical outcome of symptomatic treatment-related changes after gamma knife radiosurgery in patients with brain metastases Kim, JH; Choi, JW; Kong, DS; Seol, HJ; Nam, D; Ryu, JW; Kim, ST; Suh, YL; Lee, JI
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  • J NEUROSURG 2022 10.3171/2021.2.JNS203867 Endoscopic endonasal and transorbital approaches to petrous apex lesions Lee, WJ; Hong, SD; Woo, KI; Seol, HJ; Choi, JW; Lee, JI; Nam, DH; Kong, DS
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  • WORLD NEUROSURG 2022 10.1016/j.wneu.2021.11.003 Graded Reconstruction Strategy Using a Multilayer Technique Without Lumbar Drainage After Endoscopic Endonasal Surgery Ha, CM; Hong, SD; Choi, JW; Seol, HJ; Nam, DH; Lee, JI; Kong, DS
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  • J NEURO-ONCOL 2022 10.1007/s11060-021-03930-4 Bevacizumab plus irinotecan with or without gamma knife radiosurgery after failure of concurrent chemo-radiotherapy for high-grade glioma Lee, YP; Jung, HA; Lee, MS; Choi, JW; Kong, DS; Seol, HJ; Nam, DH; Lee, JI; Lee, SH
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  • PLOS ONE 2021 10.1371/journal.pone.0251998 High-dose drug heat map analysis for drug safety and efficacy in multi-spheroid brain normal cells and GBM patient-derived cells Lee, SY; Teng, Y; Son, M; Ku, B; Moon, HS; Tergaonkar, V; Chow, PKH; Lee, DW; Nam, DH
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  • BIOMED PHARMACOTHER 2021 10.1016/j.biopha.2021.112278 Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses Nickel, AC; Picard, D; Qin, N; Wolter, M; Kaulich, K; Hewera, M; Pauck, D; Marquardt, V; Torga, G; Muhammad, S; Zhang, W; Schnell, O; Steiger, HJ; Hanggi, D; Fritsche, E; Her, NG; Nam, DH; Carro, MS; Remke, M; Reifenberger, G; Kahlert, UD
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  • MOLECULES 2021 10.3390/molecules26164949 Three-Dimensional Aggregated Spheroid Model of Hepatocellular Carcinoma Using a 96-Pillar/Well Plate Lee, SY; Teng, YN; Son, M; Ku, B; Hwang, HJ; Tergaonkar, V; Chow, PKH; Lee, DW; Nam, D
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  • WORLD NEUROSURG 2021 10.1016/j.wneu.2021.03.085 Safety and Efficacy of Endoscopic Dorsum Sellar Resection for Access to Retroinfundibular or Upper Clival Tumors (Korean Society of Endoscopic Neurosurgery-008) Kong1, DS; Hong, SD; Kang, H; Seo, Y; Kim, MS; Seol, HJ; Park, CK; Nam, DH; Lee, JI; Kim, YH
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  • INT J MOL SCI 2021 10.3390/ijms22126240 Semi-Automated Cell Panning for Efficient Isolation of FGFR3-Targeting Antibody Min1, B; Yoo, M; Kim, H; Cho, M; Nam, DH; Yoon, Y
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  • J NEURO-ONCOL 2021 10.1007/s11060-021-03774-y Early hormonal recovery following endoscopic transsphenoidal surgery for silent non-functioning pituitary adenomas with hormone dysfunction Lee1, MH; Hur, KY; Hong, SD; Seol, HJ; Choi, JW; Lee, JI; Nam, D; Kong, DS
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  • EUR ARCH OTO-RHINO-L 2021 10.1007/s00405-021-06877-4 Learning curve and technical nuances of endoscopic skull base reconstruction with nasoseptal flap to control high-flow cerebrospinal fluid leakage: reconstruction after endoscopic skull base surgery other than pituitary surgery Park1, W; Nam, D; Kong, DS; Lee, KE; Park, SI; Kim, HY; Chung, SK; Jung, YG; Hong, SD
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  • J KOREAN MED SCI 2021 10.3346/jkms.2021.36.e102 Optimal Volume of the Residual Tumor to Predict Long-term Tumor Control Using Stereotactic Radiosurgery after Facial Nerve-preserving Surgery for Vestibular Schwannomas Lee1, WJ; Lee, JI; Choi, JW; Kong, DS; Nam, DH; Cho, YS; Shin, HJ; Seol, HJ
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  • CELL DEATH DIS 2021 10.1038/s41419-021-03657-0 Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma Choi1, SW; Lee, Y; Shin, K; Koo, H; Kim, D; Sa, JK; Cho, HJ; Shin, HM; Lee, SJ; Kim, H; Chung, S; Shin, J; Lee, C; Nam, DH
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  • J KOREAN NEUROSURG SOC 2021 10.3340/jkns.2020.0135 Immune Checkpoint Inhibitors for Non-Small-Cell Lung Cancer with Brain Metastasis : The Role of Gamma Knife Radiosurgery Lee1, MH; Cho, KR; Choi, JW; Kong, DS; Seol, HJ; Nam, DH; Jung, HA; Sun, JM; Lee, SH; Ahn, JS; Ahn, MJ; Park, K; Lee, JI
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  • ISCIENCE 2021 10.1016/j.isci.2021.102238 Azathioprine antagonizes aberrantly elevated lipid metabolism and induces apoptosis in glioblastoma Nam1, HJ; Kim, YE; Moon, BS; Kim, HY; Jung, D; Choi, S; Jang, JW; Nam, DH; Cho, H
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  • CANCER LETT 2021 10.1016/j.canlet.2020.10.050 Clinical practice guidelines for the management of adult diffuse gliomas Jiang1, T; Nam, DH; Ram, Z; Poon, WS; Wang, JG; Boldbaatar, D; Mao, Y; Ma, WB; Mao, Q; You, YP; Jiang, CL; Yang, XJ; Kang, CS; Qiu, XG; Li, WB; Li, SW; Chen, L; Li, XJ; Liu, ZX; Wang, WM; Bai, HM; Yao, Y; Li, SW; Wu, AH; Sai, K; Li, GL; Yao, K; Wei, XT; Liu, XZ; Zhang, ZW; Dai, YW; Lv, SQ; Wang, L; Lin, ZX; Dong, J; Xu, GZ; Ma, XD; Zhang, W; Zhang, CB; Chen, BS; You, G; Wang, YZ; Wang, YY; Bao, ZS; Yang, P; Fan, X; Liu, X; Zhao, Z; Wang, Z; Li, YM; Wang, ZL; Li, GZ; Fang, SY; Li, LW; Liu, YW; Liu, S; Shan, X; Liu, YQ; Chai, RC; Hu, HM; Chen, J; Yan, W; Cai, JQ; Wang, HJ; Chen, LC; Yang, Y; Wang, Y; Han, L; Wang, QX
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  • BRAIN 2021 10.1093/brain/awaa433 Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma Hong1, JH; Kang, S; Sa, JK; Park, G; Oh, YT; Kim, TH; Yin, J; Kim, SS; D'Angelo, F; Koo, H; You, Y; Park, S; Kwon, HJ; Kim, CI; Ryu, H; Lin, W; Park, EJ; Kim, YJ; Park, MJ; Kim, H; Kim, MS; Chung, S; Park, CK; Park, SH; Kang, YH; Kim, JH; Saya, H; Nakano, I; Gwak, HS; Yoo, H; Lee, J; Hur, EM; Shi, BY; Nam, DH; Iavarone, A; Lee, SH; Park, JB
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  • CANCERS 2021 10.3390/cancers13030372 High-Content Analysis-Based Sensitivity Prediction and Novel Therapeutics Screening for c-Met-Addicted Glioblastoma Oh1, JW; Oh, YJ; Han, S; Her, NG; Nam, DH
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  • STEREOT FUNCT NEUROS 2020 10.1159/000508737 Gamma Knife Radiosurgery as a Primary Treatment for Nonfunctioning Pituitary Adenoma Invading the Cavernous Sinus Lee1, WJ; Cho, KR; Choi, JW; Kong, DS; Seol, HJ; Nam, DH; Lee, JI
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  • CANCERS 2020 10.3390/cancers12113210 Therapeutic Efficacy of GC1118, a Novel Anti-EGFR Antibody, against Glioblastoma with High EGFR Amplification in Patient-Derived Xenografts Lee1, K; Koo, H; Kim, YJ; Kim, D; Son, E; Yang, H; Lim, Y; Hur, M; Lee, HW; Choi, SW; Nam, DH
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  • ACS OMEGA 2020 10.1021/acsomega.0c03102 cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors Min1, B; Jin, J; Kim, H; Her, NG; Park, C; Kim, D; Yang, J; Hwang, J; Kim, E; Choi, M; Song, HY; Nam, DH; Yoon, Y
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  • Lab Invest. 2012 Mar;92(3):466-73. doi: 10.1038/labinvest.2011.161. Epub 2011 Nov 14. Wnt activation is implicated in glioblastoma radioresistance Kim Y11, Kim KH, Lee J, Lee YA, Kim M, Lee SJ, Park K, Yang H, Jin J, Joo KM, Lee J, Nam DH.
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  • Biochem Biophys Res Commun. 2012 Feb 10;418(2):359-65. doi: 10.1016/j.bbrc.2012.01.026. Epub 2012 Jan 17. Replacement of microglial cells using Clodronate liposome and bone marrow transplantation in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis Lee JC11, Seong J, Kim SH, Lee SJ, Cho YJ, An J, Nam DH, Joo KM, Cha CI.
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  • PLoS One. 2012;7(2):e25936. doi: 10.1371/journal.pone.0025936. Epub 2012 Feb 10. Trans-Differentiation of Neural Stem Cells: A Therapeutic Mechanism Against the Radiation Induced Brain Damage Joo KM11, Jin J, Kang BG, Lee SJ, Kim KH, Yang H, Lee YA, Cho YJ, Im YS, Lee DS, Lim DH, Kim DH, Um HD, Lee SH, Lee JI, Nam DH.
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  • Cancer Lett. 2011 Dec 8;311(2):152-9. doi: 10.1016/j.canlet.2011.07.001. Epub 2011 Jul 14. Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer Seol HJ11, Jin J, Seong DH, Joo KM, Kang W, Yang H, Kim J, Shin CS, Kim Y, Kim KH, Kong DS, Lee JI, Aboody KS, Lee HJ, Kim SU, Nam DH.
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  • Bioconjug Chem. 2011 Dec 21;22(12):2568-72. doi: 10.1021/bc200406n. Epub 2011 Nov 28. In Vivo Specific Delivery of c-Met siRNA to Glioblastoma Using Cationic Solid Lipid Nanoparticles Jin J11, Bae KH, Yang H, Lee SJ, Kim H, Kim Y, Joo KM, Seo SW, Park TG, Nam DH.
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  • 없음 Mild generation of selenolate nucleophiles by thiol reduction of diselenides: convenient syntheses of selenyl-substituted aryl aldehydes
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  • Cancer Res. 2011 Nov 15;71(22):7125-34. doi: 10.1158/0008-5472.CAN-11-1330. Epub 2011 Oct 5. EGFR-AKT-Smad Signaling Promotes Formation of Glioma Stem-like Cells and Tumor Angiogenesis by ID3-Driven Cytokine Induction Jin X11, Yin J, Kim SH, Sohn YW, Beck S, Lim YC, Nam DH, Choi YJ, Kim H.
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  • Oncol Res. 2011;19(8-9):381-90. The Expression of DNA Damage Checkpoint Proteins and Prognostic Implication in Metastatic Brain Tumors Seol HJ11, Yoo HY, Jin J, Joo KM, Kim HS, Yoon SJ, Choi SH, Kim Y, Pyo HR, Lim DH, Kim W, Um HD, Kim JH, Lee JI, Nam DH.
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  • Oncol Rep. 2011 Aug;26(2):423-30. doi: 10.3892/or.2011.1325. Epub 2011 May 26. Prognostic implications of the DNA damage response pathway in glioblastoma Seol HJ11, Yoo HY, Jin J, Joo KM, Kong DS, Yoon SJ, Yang H, Kang W, Lim DH, Park K, Kim JH, Lee JI, Nam DH.
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  • Exp Mol Med. 2011 Jul 30;43(7):419-26. doi: 10.3858/emm.2011.43.7.046. Time-course analysis of DNA damage response-related genes after in vitro radiation in H460 and H1229 lung cancer cell lines Kim KH11, Yoo HY, Joo KM, Jung Y, Jin J, Kim Y, Yoon SJ, Choi SH, Seol HJ, Park WY, Nam do H.
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  • J Neurooncol. 2011 Jul;103(3):595-602. doi: 10.1007/s11060-010-0427-y. Epub 2010 Nov 4. Radiotherapy followed by adjuvant temozolomide with or without neoadjuvant ACNU-CDDP chemotherapy in newly diagnosed glioblastomas: a prospective randomized controlled multicenter phase III trial Kim IH11, Park CK, Heo DS, Kim CY, Rhee CH, Nam DH, Lee SH, Han JH, Lee SH, Kim TM, Kim DW, Kim JE, Paek SH, Kim DG, Kim IA, Kim YJ, Kim JH, Park BJ, Jung HW.
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  • Mol Ther. 2011 Jun;19(6):1161-9. doi: 10.1038/mt.2011.28. Epub 2011 Mar 8. hMSC-mediated Concurrent Delivery of Endostatin and Carboxylesterase to Mouse Xenografts Suppresses Glioma Initiation and Recurrence Yin J11, Kim JK, Moon JH, Beck S, Piao D, Jin X, Kim SH, Lim YC, Nam DH, You S, Kim H, Choi YJ.
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  • Cancer Res. 2011 Apr 15;71(8):3066-75. doi: 10.1158/0008-5472.CAN-10-1495. Epub 2011 Mar 1. Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation Jin X11, Jeon HY, Joo KM, Kim JK, Jin J, Kim SH, Kang BG, Beck S, Lee SJ, Kim JK, Park AK, Park WY, Choi YJ, Nam DH, Kim H.
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  • Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model
  • Biochem Biophys Res Commun. 2011 Mar 4;406(1):53-8. doi: 10.1016/j.bbrc.2011.01.106. Epub 2011 Feb 1. Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy Yang H11, Yoon SJ, Jin J, Choi SH, Seol HJ, Lee JI, Nam DH, Yoo HY.
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  • Mol Cells. 2010 Nov;30(5):403-8. doi: 10.1007/s10059-010-0122-z. Epub 2010 Aug 31. The Neural Stem Cell Fate Determinant TLX Promotes Tumorigenesis and Genesis of Cells Resembling Glioma Stem Cells (vol 30, pg 403, 2010) Park HJ11, Kim JK, Jeon HM, Oh SY, Kim SH, Nam DH, Kim H.
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  • AJNR Am J Neuroradiol. 2011 Feb;32(2):382-7. doi: 10.3174/ajnr.A2286. Epub 2011 Jan 20. Diagnostic Dilemma of Pseudoprogression in the Treatment of Newly Diagnosed Glioblastomas: The Role of Assessing Relative Cerebral Blood Flow Volume and Oxygen-6-Methylguanine-DNA Methyltransferase Promoter Methylation Status Kong DS11, Kim ST, Kim EH, Lim DH, Kim WS, Suh YL, Lee JI, Park K, Kim JH, Nam DH.
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  • Neurol Res. 2011 Jan;33(1):33-7. doi: 10.1179/016164110X12807570509899. Epub 2010 Aug 31. Functional neural stem cell isolation from brains of adult mutant SOD1 (SOD1(G93A)) transgenic amyotrophic lateral sclerosis (ALS) mice Lee JC11, Jin Y, Jin J, Kang BG, Nam DH, Joo KM, Cha CI.
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  • Oncol Rep. 2011 Jan;25(1):63-8. Combined treatment of tumor-tropic human neural stem cells containing the CD suicide gene effectively targets brain tumors provoking a mild immune response Lee SJ11, Kim Y, Jo MY, Kim HS, Jin Y, Kim SU, Jin J, Joo KM, Nam DH.
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  • Mol Cells. 2011 Jan;31(1):9-15. doi: 10.1007/s10059-011-0008-8. Epub 2010 Dec 24. Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression Beck S11, Jin X, Sohn YW, Kim JK, Kim SH, Yin J, Pian X, Kim SC, Nam DH, Choi YJ, Kim H.
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  • Oncol Rep. 2011 Jan;25(1):33-9. Synergistic therapeutic effects of cytokine-induced killer cells and temozolomide against glioblastoma Jin J11, Joo KM, Lee SJ, Jo MY, Kim Y, Jin Y, Kim JK, Ahn JM, Yoon MJ, Lim J, Nam DH.
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  • Cancer Res. 2010 Dec 1;70(23):9730-41. doi: 10.1158/0008-5472.CAN-10-1882. Epub 2010 Nov 23. Negative Regulation of p53 by the Long Isoform of ErbB3 Binding Protein Ebp1 in Brain Tumors Kim CK11, Nguyen TL, Joo KM, Nam DH, Park J, Lee KH, Cho SW, Ahn JY.
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  • Cancer Res. 2010 Dec 15;70(24):10411-21. doi: 10.1158/0008-5472.CAN-10-2591. Epub 2010 Nov 5. CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche Kim M11, Koh YJ, Kim KE, Koh BI, Nam DH, Alitalo K, Kim I, Koh GY.
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  • Exp Ther Med. 2010 Nov;1(6):943-946. Epub 2010 Aug 26. Schedule-dependent synergistic effect of rituximab on methotrexate chemotherapy against lymphoma of the central nervous system Jin J11, Joo KM, Nam Y, Kim DH, Lee SJ, Jo MY, Jin Y, Kim HS, Seo SW, Kim SJ, Nam DH, Kim WS.
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  • Mol Cells. 2010 Nov;30(5):403-8. doi: 10.1007/s10059-010-0122-z. Epub 2010 Aug 31. The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells Park HJ11, Kim JK, Jeon HM, Oh SY, Kim SH, Nam DH, Kim H.
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  • BMC Cancer. 2010 Aug 13;10:424. doi: 10.1186/1471-2407-10-424. Impact of adjuvant chemotherapy for gliomatosis cerebri Kong DS11, Kim ST, Lee JI, Suh YL, Lim do H, Kim WS, Kwon KH, Park K, Kim JH, Nam DH.
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  • Neuro Oncol. 2010 Mar;12(3):289-96. doi: 10.1093/neuonc/nop030. Epub 2010 Jan 11. Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma Kong DS11, Lee JI, Kim JH, Kim ST, Kim WS, Suh YL, Dong SM, Nam DH.
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  • Clin Neurol Neurosurg. 2009 Nov;111(9):748-51. doi: 10.1016/j.clineuro.2009.07.014. Epub 2009 Aug 28. Efficacy of temozolomide as adjuvant chemotherapy after postsurgical radiotherapy alone for glioblastomas Rhee DJ11, Kong DS, Kim WS, Park KB, Lee JI, Suh YL, Song SY, Kim ST, Lim DH, Park K, Kim JH, Nam DH.
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  • Clin Neurol Neurosurg. 2009 Oct;111(8):679-82. doi: 10.1016/j.clineuro.2009.06.013. Epub 2009 Jul 28. Clinical outcome of concomitant chemoradiotherapy followed by adjuvant temozolomide therapy for glioblastaomas: Single-center experience Jeon HJ11, Kong DS, Park KB, Lee JI, Park K, Kim JH, Kim ST, Lim do H, Kim WS, Nam DH.
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  • Cell Stem Cell. 2009 May 8;4(5):440-52. doi: 10.1016/j.stem.2009.03.003. SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma Son MJ11, Woolard K, Nam DH, Lee J, Fine HA.
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  • Mol Ther. 2009 Mar;17(3):570-5. doi: 10.1038/mt.2008.290. Epub 2009 Jan 6. Human Neural Stem Cells Can Target and Deliver Therapeutic Genes to Breast Cancer Brain Metastases Joo KM11, Park IH, Shin JY, Jin J, Kang BG, Kim MH, Lee SJ, Jo MY, Kim SU, Nam DH.
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  • Cancer. 2009 Jan 1;115(1):140-8. doi: 10.1002/cncr.23972. Prognostic Significance of c-Met Expression in Glioblastomas Kong DS11, Song SY, Kim DH, Joo KM, Yoo JS, Koh JS, Dong SM, Suh YL, Lee JI, Park K, Kim JH, Nam DH.
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  • Int J Oncol. 2008 Oct;33(4):705-12. Response of brain specific microenvironment to P-glycoprotein inhibitor: An important factor determining therapeutic effect of P-glycoprotein inhibitor on brain metastatic tumors Joo KM11, Song SY, Park K, Kim MH, Jin J, Kang BG, Jang MJ, Lee GS, Kim MS, Nam DH.
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  • Genes Dev. 2008 Aug 1;22(15):2028-33. doi: 10.1101/gad.1668708. Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling Jeon HM11, Jin X, Lee JS, Oh SY, Sohn YW, Park HJ, Joo KM, Park WY, Nam DH, DePinho RA, Chin L, Kim H.
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  • Lab Invest. 2008 Aug;88(8):808-15. doi: 10.1038/labinvest.2008.57. Epub 2008 Jun 16. Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas Joo KM11, Kim SY, Jin X, Song SY, Kong DS, Lee JI, Jeon JW, Kim MH, Kang BG, Jung Y, Jin J, Hong SC, Park WY, Lee DS, Kim H, Nam DH.
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  • J Clin Neurosci. 2008 Jun;15(6):721-2; author reply 722-3. doi: 10.1016/j.jocn.2007.08.031. Epub 2008 Apr 10. Reply to letter regarding Tc-99m-Tetrofosmin SPECT for the assessment of meningioma malignancy Alexiou GA1, Tsiouris S, Goussia A, Polyzoidis KS, Fotopoulos AD, Kyritsis AP.
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  • Cancer. 2008 May 1;112(9):2046-51. doi: 10.1002/cncr.23402. Efficacy of stereotactic radiosurgery as a salvage treatment for recurrent malignant gliomas Kong DS11, Lee JI, Park K, Kim JH, Lim DH, Nam DH.
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  • Oncol Rep. 2008 Mar;19(3):639-43. The progression of gliomas is associated with cancer stem cell phenotype Kong DS11, Kim MH, Park WY, Suh YL, Lee JI, Park K, Kim JH, Nam DH.
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  • Oncol Rep. 2008 Jan;19(1):17-23. Oral paclitaxel chemotherapy for brain tumors: Ideal combination treatment of paclitaxel and P-glycoprotein inhibitor Joo KM11, Park K, Kong DS, Song SY, Kim MH, Lee GS, Kim MS, Nam DH.
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  • J Clin Neurosci. 2007 Aug;14(8):747-53. Epub 2007 May 17. Relationship between malignant subtypes of meningioma and clinical outcome Ko KW11, Nam DH, Kong DS, Lee JI, Park K, Kim JH.
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  • Headache. 2007 Feb;47(2):199-203. Atypical spontaneous intracranial hypotension (SIH) with nonorthostatic headache Kong DS11, Park K, Nam DH, Lee JI, Kim ES, Kim JS, Hong SC, Shin HJ, Eoh W, Kim JH.
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  • J Phys Chem B. 2012 Nov 8;116(44):13228-38. doi: 10.1021/jp3032918. Epub 2012 Oct 30. Development of a T-1 contrast agent for magnetic resonance imaging using MnO nanoparticles L?tourneau M11, Tremblay M, Faucher L, Rojas D, Chevallier P, Gossuin Y, Lagueux J, Fortin MA.
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  • Oncol Rep. 2006 Nov;16(5):1117-21. A pilot study of metronomic temozolomide treatment in patients with recurrent temozolomide-refractory glioblastoma Kong DS11, Lee JI, Kim WS, Son MJ, Lim do H, Kim ST, Park K, Kim JH, Eoh W, Nam DH.
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  • Oncol Rep. 2006 Jul;16(1):33-9. Metronomic treatment of temozolomide inhibits tumor cell growth through reduction of angiogenesis and augmentation of apoptosis in orthotopic models of gliomas Kim JT11, Kim JS, Ko KW, Kong DS, Kang CM, Kim MH, Son MJ, Song HS, Shin HJ, Lee DS, Eoh W, Nam DH.
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  • Int J Oncol. 2006 Jun;28(6):1385-92. Synergistic effect and condition of pegylated interferon a with paclitaxel on glioblastoma Son MJ11, Song HS, Kim MH, Kim JT, Kang CM, Jeon JW, Park SY, Kim YJ, Groves MD, Park K, Kim JH, Nam DH.
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  • Oncol Rep. 2006 May;15(5):1163-8. Antiangiogenic agent, thalidomide increases the antitumor effect of single high dose irradiation (gamma knife radiosurgery) in the rat orthotopic glioma model Lee JI11, Itasaka S, Kim JT, Nam DH.
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  • Oncol Rep. 2006 Jan;15(1):7-13. Combination celecoxib and temozolomide in C6 rat glioma orthotopic model Kang SG11, Kim JS, Park K, Kim JS, Groves MD, Nam DH.
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  • Int J Oncol. 2006 Jan;28(1):53-9. Combination treatment with temozolomide and thalidomide inhibits tumor growth and angiogenesis in an orthotopic glioma model Son MJ11, Kim JS, Kim MH, Song HS, Kim JT, Kim H, Shin T, Jeon HJ, Lee DS, Park SY, Kim YJ, Kim JH, Nam DH.
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  • Neurol Med Chir (Tokyo). 2005 May;45(5):232-8; discussion 238-9. Clinical and radiological prognostic factors of anaplastic oligodendroglioma treated by combined therapy Kang SG11, Kim JH, Nam DH, Park K.
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  • Oncol Rep. 2004 Apr;11(4):863-9. Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: prognostic significance Nam DH11, Park K, Suh YL, Kim JH.
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  • Neurosci Lett. 2001 Oct 12;312(1):41-4. Expression of interleukin-1 beta in lipopolysaccharide stimulated monocytes derived from patients with aneurysmal subarachnoid hemorrhage is correlated with cerebral vasospasm Nam DH11, Kim JS, Hong SC, Lee WH, Lee JI, Shin HJ, Park K, Eoh W, Han DH, Kim JH.
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  • Exp Mol Med. 2001 Sep 30;33(3):111-6. Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas Nam DH11, Song SY, Park K, Kim MH, Suh YL, Lee JI, Kim JS, Hong SC, Shin HJ, Park K, Eoh W, Kim JH.
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  • Int J Oncol. 2001 Jan;18(1):111-6. The detection of p53 gene mutation using a microdissection technique in primary intracranial germ cell tumors Kim SK11, Cho BK, Paek SH, Hong SJ, Kim HS, Hong SY, Choe G, Chi JG, Nam DH, Wang KC.
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  • Neurosci Lett. 2000 Mar 31;283(1):45-8. Vascular endothelial growth factor expression under ischemic stress in human meningiomas Park K11, Kim JH, Nam DH, Lee JI, Kim JS, Hong SC, Shin HJ, Eoh W, Park K.
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  • Childs Nerv Syst. 1999 Apr;15(4):185-91. Treatment of intracranial nongerminomatous malignant germ cell tumor in children: the role of each treatment modality Nam DH11, Cho BK, Shin HJ, Ahn HS, Kim IH, Wang KC.
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