삼성서울병원

Ko En

신경외과 남도현 교수

진료분야
뇌하수체종양, 뇌교종, 전이성 뇌종양, 악성뇌종양
진료일정 07 月
날짜
01
02
03
04
05
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
오전
오후
진료일정 08 月
날짜
01
02
03
04
05
06
07
08
09
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
오전
오후

학력

학력
2001.02 서울대학교 대학원 의학과 (박사)
1997.02 서울대학교 대학원 의학과 (석사)
1988.02 서울대학교 의과대학 졸업 (의학사)

경력

경력
2009.12 ~현재 삼성 난치암 연구사업단 단장
2009.04 ~현재 성균관의대 신경외과학교실 교수
2008.01 ~현재 암줄기세포 연구센터장
1998.03 ~현재 삼성서울병원 신경외과 전문의
2013.03 ~ 2017.02 삼성 융합의과학과 과장
2003.04 ~ 2009.03 성균관의대 신경외과학교실 부교수
2002.02 ~ 2004.01 미국 Univ. of Texas MD Anderson Cancer Center 연구원
1999.03 ~ 2003.03 성균관의대 신경외과학교실 조교수
1997.03 ~ 1998.02 삼성서울병원 신경외과 전임의
1996.05 ~ 1997.02 서울대학병원 신경외과 전임의
1989.03 ~ 1993.02 서울대학교병원 신경외과 레지던트 과정 수료
1988.03 ~ 1989.02 서울대학교병원 인턴 과정 수료

연구분야

연구분야
뇌종양 개인 맞춤 치료(아바타) 및 유전체 연구
본 연구실은 암환자에게 최적의 치료 솔루션을 제시할 수 있는 개인 맞춤 의학 실현을 위해 환자와 유전체 정보 및 약물정보를 연결해주는 인터페이스 개발을 목표로 연구하고 있다. 이를 위하여 암줄기세포를 표적으로 하여 특정 신호전달체계와 유전자 발현의 특성에 대한 연구를 진행하고 있으며, 특히 교모세포종 환자로부터 암줄기세포를 분리하여 배양하는 방법을 국내 최초로 확립하였다. 환자 유래 샘플 라이브러리를 통한 아바타 모델을 확립하여 유전체 기반 개인 맞춤 치료 플랫폼을 구축하였고 암 환자에게 최적의 치료 솔루션을 제공할 수 있는 인터페이스 역할인 아바타 스캔 시스템을 개발 중이다.
뇌하수체 종양 내시경 수술기법 연구
뇌하수체 종양은 전체 뇌종양의 10~15%의 빈도를 차지하고 있는 질환으로, 해부학적 위치의 특성상 두개절개술로 접근하기에 여러 가지 어려움이 있습니다. 이에 대한 수술적 접근을 위해 경접형동 접근법(Trans-sphenoidal approach)를 통한 현미경적 수술이 과거부터 사용되어 왔으나, 수술시야에서 한계가 많아 적용범위가 제한적이었습니다. 최근 장비의 발전과 여러 수술법의 개발로 내시경을 이용한 경접형동 접근법 수술이 증가하는 추세이며, 이 방법을 이용하여 뇌하수체 선종 뿐 아니라 두개인두종, 척삭종 및 터키안결절 부위에서 발생한 뇌수종까지 적용범위가 늘어나고 있습니다. 그러나 내시경을 이용한 경접형동 접근법 수술법을 시행하게 되면 현미경적 수술법에 비해 코점막의 손상이 크고 수술 후 후각기능의 저하가 심하다는 것과 뇌척수액 누출의 위험성이 상대적으로 높다는 치명적인 단점이 있습니다. 이에 이비인후과와 협진하여 코점막의 손상을 최소화하면서도 안전하고 효과적인 내시경 수술기법을 시행하기 위한 여러 가지 연구를 진행하고 있습니다.
  • Nat Genet. 2017 Apr;49(4):594-599. doi: 10.1038/ng.3806. Epub 2017 Mar 6. Spatiotemporal genomic architecture informs precision oncology in glioblastoma Lee JK11,2, Wang J3,4,5, Sa JK1,2,6, Ladewig E3,4, Lee HO7, Lee IH1,2, Kang HJ1,2, Rosenbloom DS3,4, Camara PG3,4, Liu Z3,4, van Nieuwenhuizen P3,4, Jung SW1,2,6, Choi SW1,2,6, Kim J1,2, Chen A3,4, Kim KT7, Shin S1,2,6, Seo YJ1,2, Oh JM1,2, Shin YJ1,2,7, Park CK8, Kong DS2, Seol HJ2, Blumberg A9, Lee JI2, Iavarone A10,11,12, Park WY6,7, Rabadan R3,4, Nam DH1,2,6.
    View PubMed
  • Org Biomol Chem. 2017 Feb 1;15(5):1198-1208. doi: 10.1039/c6ob02729f. Synthesis and anticancer activity of benzoselenophene and heteroaromatic derivatives of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) Mhetre AB11, Lee H1, Yang H2, Lee K2, Nam DH2, Lim D1.
    View PubMed
  • J Clin Neurosci. 2017 Jan;35:35-41. doi: 10.1016/j.jocn.2016.10.002. Epub 2016 Oct 18. Gamma knife radiosurgery for residual or recurrent intracranial hemangiopericytomas Kim BS11, Kong DS2, Seol HJ2, Nam DH2, Lee JI3.
    View PubMed
  • J Korean Neurosurg Soc. 2017 Jan 1;60(1):21-29. doi: 10.3340/jkns.2016.0404.005. Epub 2016 Dec 29. The Influence of Biomarker Mutations and Systemic Treatment on Cerebral Metastases from NSCLC Treated with Radiosurgery Lee MH11, Kong DS1, Seol HJ1, Nam DH1, Lee JI1.
    View PubMed
  • Oncotarget. 2017 Jan 24;8(4):7003-7013. doi: 10.18632/oncotarget.12273. Phase III randomized trial of autologous cytokine-induced killer cell immunotherapy for newly diagnosed glioblastoma in korea Kong DS11, Nam DH1, Kang SH2, Lee JW3, Chang JH4, Kim JH5, Lim YJ6, Koh YC7, Chung YG2, Kim JM8, Kim CH8.
    View PubMed
  • Oncotarget. 2017 Jan 3;8(1):1321-1328. doi: 10.18632/oncotarget.13616. Genomic and transcriptomic characterization of skull base chordoma Sa JK11,2,3, Lee IH2,3, Hong SD4, Kong DS2,3,5, Nam DH1,2,3,5.
    View PubMed
  • Cancer Res Treat. 2017 Jan;49(1):193-203. doi: 10.4143/crt.2015.473. Epub 2016 Jun 27. Concurrent Chemoradiotherapy with Temozolomide Followed by Adjuvant Temozolomide for Newly Diagnosed Glioblastoma Patients: A Retrospective Multicenter Observation Study in Korea Kim BS11, Seol HJ2, Nam DH2, Park CK3, Kim IH4, Kim TM5, Kim JH6, Cho YH6, Yoon SM7, Chang JH8, Kang SG8, Kim EH8, Suh CO9, Jung TY10, Lee KH11, Kim CY12, Kim IA13, Hong CK14, Yoo H15, Kim JH16, Kang SH17, Kang MK18, Kim EY19, Kim SH20, Chung DS21, Hwang SC22, Song JH23, Cho SJ24, Lee SI25, Lee YS26, Ahn KJ27, Kim SH28, Lim DH29, Gwak HS30, Lee SH31, Hong YK32.
    View PubMed
  • Oncotarget. 2017 Jan 31;8(5):8342-8355. doi: 10.18632/oncotarget.14184. MicroRNA-1908-5p contributes to the oncogenic function of the splicing factor SRSF3 Kim HR11, Shin CH1, Lee H1, Choi KH1, Nam DH1,2, Ohn T3, Kim HH1,4.
    View PubMed
  • Cancer Med. 2016 Dec;5(12):3615-3621. doi: 10.1002/cam4.955. Epub 2016 Nov 23. Analysis of risk factors to predict communicating hydrocephalus following gamma knife radiosurgery for intracranial schwannoma Lee S11, Seo SW2, Hwang J1, Seol HJ1, Nam DH1, Lee JI1, Kong DS1.
    View PubMed
  • World Neurosurg. 2016 Nov;95:399-405. doi: 10.1016/j.wneu.2016.08.046. Epub 2016 Aug 24. Outcomes of Gamma Knife Radiosurgery in Combination with Crizotinib for Patients with Brain Metastasis from Non-Small Cell Lung Cancer Choi JW11, Kong DS1, Seol HJ1, Nam DH1, Yoo KH2, Sun JM2, Ahn JS2, Ahn MJ2, Park K2, Lee JI3.
    View PubMed
  • Neurosurg Rev. 2016 Oct;39(4):643-53. doi: 10.1007/s10143-016-0728-5. Epub 2016 May 4. Clinical outcome of neurofibromatosis type 2-related vestibular schwannoma: treatment strategies and challenges Kim BS11, Seol HJ2, Lee JI3, Shin HJ3, Park K3, Kong DS3, Nam DH3, Cho YS4.
    View PubMed
  • World Neurosurg. 2016 Sep;93:164-7. doi: 10.1016/j.wneu.2016.06.006. Epub 2016 Jun 11. Nasoseptal Flap Elevation in Patients with History of Septal Surgery: Does It Increase Flap Failure or Cerebrospinal Fluid Leakage? Park W11, Hong SD2, Nam DH3, Kong DS3, Ryu G1, Kim HY1, Chung SK1, Dhong HJ1.
    View PubMed
  • Oncotarget. 2016 Aug 9;7(32):51626-51639. doi: 10.18632/oncotarget.10539. Establishment and antitumor effects of dasatinib and PKI-587 in BD-138T, a patient-derived muscle invasive bladder cancer preclinical platform with concomitant EGFR amplification and PTEN deletion Chang N11,2,3, Lee HW3,4, Lim JE5, Jeong DE1, Song HJ6, Kim S3,7, Nam DH1,2,3, Sung HH5, Jeong BC5, Seo SI5, Jeon SS5, Lee HM5, Choi HY5, Jeon HG5.
    View PubMed
  • PLoS One. 2016 Jul 8;11(7):e0158639. doi: 10.1371/journal.pone.0158639. eCollection 2016. Sensitive Tumorigenic Potential Evaluation of Adult Human Multipotent Neural Cells Immortalized by hTERT Gene Transduction Lee KH11,2, Nam H3,2, Jeong da E1,2, Kim SS1,2, Song HJ4,2, Pyeon HJ4,2, Kang K4, Hong SC1,2, Nam DH1,3,2, Joo KM1,4,2.
    View PubMed
  • Medicine (Baltimore). 2016 Jul;95(27):e4109. doi: 10.1097/MD.0000000000004109. Integrative radiogenomic analysis for genomic signatures in glioblastomas presenting leptomeningeal dissemination You HJ11, Park HY, Kim J, Lee IH, Seol HJ, Lee JI, Kim ST, Kong DS, Nam DH.
    View PubMed
  • Nat Genet. 2016 Jul;48(7):768-76. doi: 10.1038/ng.3590. Epub 2016 Jun 6. Clonal evolution of glioblastoma under therapy Wang J11,2, Cazzato E3, Ladewig E1,2, Frattini V4, Rosenbloom DI1,2, Zairis S1,2, Abate F1,2, Liu Z1,2, Elliott O1,2, Shin YJ5, Lee JK5, Lee IH5, Park WY6, Eoli M3, Blumberg AJ7, Lasorella A4,8,9, Nam DH5,10, Finocchiaro G3, Iavarone A4,9,11, Rabadan R1,2.
    View PubMed
  • SENSORS AND ACTUATORS B-CHEMICAL, JUN 2 2016, 228:523-528, DOI: 10.1016/j.snb.2016.01.011 Unified 2D and 3D cell-based high-throughput screening platform using a micropillar/microwell chip Lee DW1, Doh I, Nam DH
    View PubMed
  • World Neurosurg. 2016 Jun;90:496-503. doi: 10.1016/j.wneu.2016.03.050. Epub 2016 Mar 26. Serial Re-Expansion of Pituitary Gland Is Associated with Endocrinologic Recovery Cho KR11, Hong SD2, Hur KY3, Kim ST4, Seol HJ1, Lee JI1, Kong DS5, Nam DH6.
    View PubMed
  • Oncotarget. 2016 May 17;7(20):29400-11. doi: 10.18632/oncotarget.8837. Anti-miR delivery strategies to bypass the blood-brain barrier in glioblastoma therapy Kim DG11,2, Kim KH2, Seo YJ2, Yang H2,3, Marcusson EG4, Son E2,5, Lee K1,2, Sa JK1,2, Lee HW1,2,6, Nam DH1,2,3.
    View PubMed
  • Headache. 2016 Apr 4. doi: 10.1111/head.12801. Gamma Knife Radiosurgery for Trigeminal Neuralgia Secondary to Benign Lesions Cho KR11, Lee MH1, Im YS1, Kong DS1, Seol HJ1, Nam DH1, Lee JI1.
    View PubMed
  • World Neurosurg. 2016 May;89:215-22. doi: 10.1016/j.wneu.2016.01.038. Epub 2016 Jan 28. Functional Outcome of the Facial Nerve After Surgery for Vestibular Schwannoma: Prediction of Acceptable Long-Term Facial Nerve Function Based on Immediate Postoperative Facial Palsy Lee S11, Seol HJ2, Park K1, Lee JI1, Nam DH1, Kong DS1, Cho YS3.
    View PubMed
  • Genome Biol. 2016 Apr 29;17:80. doi: 10.1186/s13059-016-0945-9. Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma Kim KT11, Lee HW2, Lee HO1,3, Song HJ4, Jeong da E5, Shin S5, Kim H6, Shin Y6, Nam DH5,7, Jeong BC8, Kirsch DG9,10, Joo KM11,12, Park WY13,14,15.
    View PubMed
  • Int J Oncol. 2016 Mar;48(3):1053-62. doi: 10.3892/ijo.2016.3328. Epub 2016 Jan 11. Involvement of DDX6 gene in radio- and chemoresistance in glioblastoma Cho YJ11, Kang W2, Kim SH3, Sa JK4, Kim N4, Paddison PJ5, Kim M6, Joo KM3, Hwang YI1, Nam DH7.
    View PubMed
  • World Neurosurg. 2016 Mar;87:162-9. doi: 10.1016/j.wneu.2015.12.050. Epub 2015 Dec 28. Endoscopic Modified Transseptal Transsphenoidal Approach for Maximal Preservation of Sinonasal Quality of Life and Olfaction Hong SD11, Nam DH2, Kong DS3, Kim HY1, Chung SK1, Dhong HJ4.
    View PubMed
  • Oncotarget. 2016 Mar 8;7(10):11526-38. doi: 10.18632/oncotarget.7115. Integrative radiogenomic analysis for multicentric radiophenotype in glioblastoma Kong DS11,2,3,4, Kim J2,3,4, Lee IH2,3,4, Kim ST5, Seol HJ1, Lee JI1, Park WY6, Ryu G7, Wang Z7, Ma'ayan A7, Nam DH1,2,3,4.
    View PubMed
  • Cancer Res. 2016 Mar 1;76(5):1044-54. doi: 10.1158/0008-5472.CAN-14-2611. Epub 2015 Dec 16. Novel Morphologic and Genetic Analysis of Cancer Cells in a 3D Microenvironment Identifies STAT3 as a Regulator of Tumor Permeability Barrier Function Park MC11, Jeong H2, Son SH3, Kim Y4, Han D4, Goughnour PC4, Kang T3, Kwon NH3, Moon HE5, Paek SH5, Hwang D6, Seol HJ7, Nam DH7, Kim S8.
    View PubMed
  • Histol Histopathol. 2016 Mar;31(3):269-83. doi: 10.14670/HH-11-695. Epub 2015 Nov 18. Facilitating tailored therapeutic strategies for glioblastoma through an orthotopic patient-derived xenograft platform Lee HW11, Lee K2, Kim DG3, Yang H4, Nam DH5.
    View PubMed
  • Oncol Lett. 2016 Feb;11(2):1281-1286. Epub 2016 Jan 7. Repurposing antipsychotics as glioblastoma therapeutics: Potentials and challenges Lee JK11, Nam DH1, Lee J2.
    View PubMed
  • Lab Invest. 2016 Feb;96(2):137-50. doi: 10.1038/labinvest.2015.140. Epub 2015 Dec 7. WNT signaling in glioblastoma and therapeutic opportunities Lee Y11, Lee JK2, Ahn SH1, Lee J3, Nam DH1,4.
    View PubMed
  • Mol Cancer Ther. 2016 Feb;15(2):251-63. doi: 10.1158/1535-7163.MCT-15-0679. Epub 2015 Nov 19. GC1118, an Anti-EGFR Antibody with a Distinct Binding Epitope and Superior Inhibitory Activity against High-Affinity EGFR Ligands Lim Y11, Yoo J2, Kim MS1, Hur M3, Lee EH1, Hur HS1, Lee JC1, Lee SN1, Park TW1, Lee K1, Chang KH1, Kim K2, Kang Y2, Hong KW1, Kim SH4, Kim YG5, Yoon Y6, Nam DH7, Yang H8, Kim DG9, Cho HS10, Won J11.
    View PubMed
  • Neuro Oncol. 2016 Jan;18(1):37-47. doi: 10.1093/neuonc/nov091. Epub 2015 Jun 1. USP1 targeting impedes GBM growth by inhibiting stem cell maintenance and radioresistance Lee JK11, Chang N1, Yoon Y1, Yang H1, Cho H1, Kim E1, Shin Y1, Kang W1, Oh YT1, Mun GI1, Joo KM1, Nam DH1, Lee J1.
    View PubMed
  • J Korean Neurosurg Soc. 2016 Jan;59(1):44-51. doi: 10.3340/jkns.2016.59.1.44. Epub 2016 Jan 20. Malignant Glioma with Neuronal Marker Expression : A Clinicopathological Study of 18 Cases Kim HR11, Lee JJ2, Lee JI3, Nam DH3, Suh YL2, Seol HJ3.
    View PubMed
  • Cell Rep. 2015 Dec 22;13(11):2425-39. doi: 10.1016/j.celrep.2015.11.021. Epub 2015 Dec 7. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells Toledo CM11, Ding Y2, Hoellerbauer P1, Davis RJ3, Basom R4, Girard EJ5, Lee E6, Corrin P2, Hart T7, Bolouri H2, Davison J4, Zhang Q4, Hardcastle J2, Aronow BJ8, Plaisier CL9, Baliga NS9, Moffat J7, Lin Q10, Li XN10, Nam DH11, Lee J12, Pollard SM13, Zhu J6, Delrow JJ4, Clurman BE14, Olson JM15, Paddison PJ16.
    View PubMed
  • BMC Cancer. 2015 Dec 24;15:1011. doi: 10.1186/s12885-015-2034-y. Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain Lee SJ11, Kang WY2,3, Yoon Y4,5, Jin JY6, Song HJ7, Her JH8, Kang SM9, Hwang YK10, Kang KJ11, Joo KM12,13,14,15, Nam DH16,17.
    View PubMed
  • World Neurosurg. 2015 Dec;84(6):1752-7. doi: 10.1016/j.wneu.2015.07.045. Epub 2015 Jul 26. Effectiveness of Postoperative Gamma Knife Radiosurgery to the Tumor Bed After Resection of Brain Metastases Choi JW11, Im YS1, Kong DS1, Seol HJ1, Nam DH1, Lee JI2.
    View PubMed
  • MAbs. 2015;7(6):1195-204. doi: 10.1080/19420862.2015.1086854. Epub 2015 Sep 1. Anticancer activity of TTAC-0001, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) monoclonal antibody, is associated with inhibition of tumor angiogenesis Kim DG11,2, Jin Y1, Jin J1, Yang H1,3, Joo KM1,2,4, Lee WS5, Shim SR5, Kim SW5, Yoo J5, Lee SH6, Yoo JS5, Nam DH1,2,3.
    View PubMed
  • J Neurooncol. 2015 Nov;125(2):331-8. doi: 10.1007/s11060-015-1915-x. Epub 2015 Sep 15. Outcome of gamma knife radiosurgery for metastatic brain tumors derived from non-small cell lung cancer Cho KR11, Lee MH1, Kong DS1, Seol HJ1, Nam DH1, Sun JM2, Ahn JS2, Ahn MJ2, Park K2, Kim ST3, Lim do H4, Lee JI5.
    View PubMed
  • PLoS One. 2015 Oct 7;10(10):e0137703. doi: 10.1371/journal.pone.0137703. eCollection 2015. FoxM1 Promotes Stemness and Radio-Resistance of Glioblastoma by Regulating the Master Stem Cell Regulator Sox2 Lee Y11, Kim KH2, Kim DG1, Cho HJ1, Kim Y3, Rheey J2, Shin K1, Seo YJ4, Choi YS4, Lee JI4, Lee J3, Joo KM5, Nam DH6.
    View PubMed
  • Oncotarget. 2015 Oct 20;6(32):33046-64. doi: 10.18632/oncotarget.5422. Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis Jeong da E11, Song HJ2, Lim S3, Lee SJ4, Lim JE5, Nam DH1,4,6, Joo KM1,2, Jeong BC5, Jeon SS5, Choi HY5, Lee HW4,7.
    View PubMed
  • Eur J Med Chem. 2015 Oct 20;103:210-22. doi: 10.1016/j.ejmech.2015.08.001. Epub 2015 Aug 4. Discovery of potent and selective cytotoxic activity of new quinazoline-ureas against TMZ-resistant glioblastoma multiforme (GBM) Elkamhawy A11, Viswanath AN2, Pae AN2, Kim HY3, Heo JC3, Park WK3, Lee CO3, Yang H4, Kim KH4, Nam DH5, Seol HJ5, Cho H6, Roh EJ7.
    View PubMed
  • J Biomol Screen. 2015 Oct;20(9):1178-84. doi: 10.1177/1087057115597635. Epub 2015 Aug 3. Automatic 3D Cell Analysis in High-Throughput Microarray Using Micropillar and Microwell Chips Lee DW11, Lee MY2, Ku B3, Nam DH4.
    View PubMed
  • J Neurooncol. 2015 Oct;125(1):207-15. doi: 10.1007/s11060-015-1902-2. Epub 2015 Sep 4. A multicenter study of anaplastic oligodendroglioma: the Korean Radiation Oncology Group Study 13-12 Kang HC11, Yu T2, Lim do H3, Kim IH2, Chung WK4, Suh CO5, Choi BO6, Cho KH7, Cho JH8, Kim JH9, Nam DH10, Park CK11, Hong YK12, Kim IA13,14.
    View PubMed
  • Oncotarget. 2015 Sep 29;6(29):27239-51. doi: 10.18632/oncotarget.4835. Talin1 targeting potentiates anti-angiogenic therapy by attenuating invasion and stem-like features of glioblastoma multiforme Kang W11,2, Kim SH3, Cho HJ4, Jin J1,2, Lee J5, Joo KM1,4,3, Nam DH4,2.
    View PubMed
  • MAbs. 2015;7(5):957-68. doi: 10.1080/19420862.2015.1045168. Epub 2015 May 5. TTAC-0001, a human monoclonal antibody targeting VEGFR-2/KDR, blocks tumor angiogenesis Lee WS11, Pyun BJ, Kim SW, Shim SR, Nam JR, Yoo JY, Jin Y, Jin J, Kwon YG, Yun CO, Nam DH, Oh K, Lee DS, Lee SH, Yoo JS.
    View PubMed
  • J Clin Neurosci. 2015 Sep;22(9):1425-9. doi: 10.1016/j.jocn.2015.02.036. Epub 2015 Jun 29. Prognostic impact of molecular phenotype in patients with recurrent anaplastic glioma treated with prolonged administration of temozolomide Kong DS11, Kim HR2, Choi YR3, Seol HJ1, Lee JI1, Nam DH4.
    View PubMed
  • Cancer Cell. 2015 Sep 14;28(3):318-28. doi: 10.1016/j.ccell.2015.07.013. Spatiotemporal Evolution of the Primary Glioblastoma Genome Kim J11, Lee IH2, Cho HJ3, Park CK4, Jung YS5, Kim Y6, Nam SH6, Kim BS5, Johnson MD7, Kong DS5, Seol HJ5, Lee JI5, Joo KM8, Yoon Y3, Park WY9, Lee J10, Park PJ11, Nam DH12.
    View PubMed
  • J Neurooncol. 2015 Aug;124(1):101-10. doi: 10.1007/s11060-015-1808-z. Epub 2015 May 31. Prognostic implication of progression pattern after anti-VEGF bevacizumab treatment for recurrent malignant gliomas Kim BS11, Kim SK, Choi SH, Lee SH, Seol HJ, Nam DH, Lee JI, Park CK, Kong DS.
    View PubMed
  • Oncotarget. 2015 Aug 21;6(24):20145-59. In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma Sa JK11,2,3, Yoon Y1, Kim M2,3, Kim Y4, Cho HJ1,2,3, Lee JK2,3, Kim GS3, Han S1,2,3, Kim WJ1,2,3, Shin YJ2,3, Joo KM1,2,3, Paddison PJ5, Ishitani T6, Lee J4, Nam DH1,2,3,7.
    View PubMed
  • Genome Biol. 2015 Jun 19;16:127. doi: 10.1186/s13059-015-0692-3. Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells Kim KT11,2, Lee HW3,4,5, Lee HO6,7, Kim SC8, Seo YJ9,10, Chung W11,12, Eum HH13,14, Nam DH15,16,17, Kim J18,19, Joo KM20,21,22, Park WY23,24,25.
    View PubMed
  • Oncotarget. 2015 Jun 30;6(18):16059-68. Correlation between tumor engraftment in patient-derived xenograft models and clinical outcomes in colorectal cancer patients Oh BY11, Lee WY1,2, Jung S3, Hong HK1, Nam DH2,4, Park YA1, Huh JW1, Yun SH1, Kim HC1, Chun HK5, Cho YB1,2,6.
    View PubMed
  • Neuro Oncol. 2015 May;17(5):708-17. doi: 10.1093/neuonc/nou356. Epub 2015 Mar 11. Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study Nabors LB11, Fink KL1, Mikkelsen T1, Grujicic D1, Tarnawski R1, Nam do H1, Mazurkiewicz M1, Salacz M1, Ashby L1, Zagonel V1, Depenni R1, Perry JR1, Hicking C1, Picard M1, Hegi ME1, Lhermitte B1, Reardon DA1.
    View PubMed
  • Am J Rhinol Allergy. 2015 May-Jun;29(3):221-5. doi: 10.2500/ajra.2015.29.4165. Endoscopic binostril versus transnasal transseptal microscopic pituitary surgery: Sinonasal quality of life and olfactory function Hong SD11, Nam do H, Seol HJ, Choi NY, Kim HY, Chung SK, Dhong HJ.
    View PubMed
  • Int J Cancer. 2015 May 1;136(9):2065-77. doi: 10.1002/ijc.29248. Epub 2014 Oct 10. Tpl2 induces castration resistant prostate cancer progression and metastasis Lee HW11, Cho HJ, Lee SJ, Song HJ, Cho HJ, Park MC, Seol HJ, Lee JI, Kim S, Lee HM, Choi HY, Nam DH, Joo KM.
    View PubMed
  • Acta Neurochir (Wien). 2015 Apr;157(4):569-76. doi: 10.1007/s00701-015-2344-5. Epub 2015 Feb 8. Optimal treatment of leptomeningeal spread in glioblastoma: analysis of risk factors and outcome Noh JH11, Lee MH, Kim WS, Lim do H, Kim ST, Kong DS, Nam DH, Lee JI, Seol HJ.
    View PubMed
  • Clin Cancer Res. 2015 Mar 1;21(5):1172-82. doi: 10.1158/1078-0432.CCR-14-1589. Epub 2014 Dec 30. Patient-Derived Xenografts from Non-Small Cell Lung Cancer Brain Metastases Are Valuable Translational Platforms for the Development of Personalized Targeted Therapy Lee HW11, Lee JI2, Lee SJ3, Cho HJ2, Song HJ4, Jeong da E5, Seo YJ2, Shin S5, Joung JG6, Kwon YJ7, Choi YL8, Park WY9, Lee HM10, Seol HJ2, Shim YM11, Joo KM12, Nam DH13.
    View PubMed
  • J Clin Neurosci. 2015 Mar;22(3):468-73. doi: 10.1016/j.jocn.2014.09.018. Epub 2015 Jan 13. Outcome of salvage treatment for recurrent glioblastoma Kim HR11, Kim KH2, Kong DS2, Seol HJ2, Nam DH2, Lim do H3, Lee JI4.
    View PubMed
  • Int J Mol Sci. 2015 Feb 25;16(3):4471-91. doi: 10.3390/ijms16034471. Tumor Progression Locus 2 (Tpl2) Kinase as a Novel Therapeutic Target for Cancer: Double-Sided Effects of Tpl2 on Cancer Lee HW11,2,3, Choi HY2, Joo KM4,5, Nam DH6,7.
    View PubMed
  • J Neurooncol. 2015 Jan;121(2):311-8. doi: 10.1007/s11060-014-1634-8. Epub 2014 Dec 9. Outcome of radiosurgery for recurrent malignant gliomas: assessment of treatment response using relative cerebral blood volume Kim HR11, Kim SH, Lee JI, Seol HJ, Nam DH, Kim ST, Park K, Kim JH, Kong DS.
    View PubMed
  • Small. 2014 Dec 29;10(24):5098-105. doi: 10.1002/smll.201401074. Epub 2014 Sep 16. High-Throughput, Miniaturized Clonogenic Analysis of a Limiting Dilution Assay on a Micropillar/Microwell Chip with Brain Tumor Cells Lee DW11, Choi YS, Seo YJ, Lee MY, Jeon SY, Ku B, Nam DH.
    View PubMed
  • Mol Cancer Ther. 2014 Dec;13(12):3049-61. doi: 10.1158/1535-7163.MCT-14-0244. Epub 2014 Oct 13. RRAD Promotes EGFR-Mediated STAT3 Activation and Induces Temozolomide Resistance of Malignant Glioblastoma Yeom SY11, Nam DH2, Park C3.
    View PubMed
  • Am J Rhinol Allergy. 2014 Nov-Dec;28(6):517-9. doi: 10.2500/ajra.2014.28.4109. Olfactory outcomes after endoscopic pituitary surgery with nasoseptal "rescue" flaps: Electrocautery versus cold knife Hong SD11, Nam DH, Park J, Kim HY, Chung SK, Dhong HJ.
    View PubMed
  • Genomics. 2014 Oct;104(4):234-41. doi: 10.1016/j.ygeno.2014.07.012. Epub 2014 Jul 25. Patterns of somatic alterations between matched primary and metastatic colorectal tumors characterized by whole-genome sequencing Xie T11, Cho YB2, Wang K3, Huang D4, Hong HK5, Choi YL6, Ko YH7, Nam DH8, Jin J9, Yang H10, Fernandez J11, Deng S12, Rejto PA13, Lee WY14, Mao M15.
    View PubMed
  • Onco Targets Ther. 2014 Oct 20;7:1933-44. doi: 10.2147/OTT.S36582. eCollection 2014. Targeting the epithelial to mesenchymal transition in glioblastoma: the emerging role of MET signaling Lee JK11, Joo KM2, Lee J3, Yoon Y4, Nam DH5.
    View PubMed
  • Biomed Res Int. 2014;2014:747415. doi: 10.1155/2014/747415. Epub 2014 Sep 10. KML001, a Telomere-Targeting Drug, Sensitizes Glioblastoma Cells to Temozolomide Chemotherapy and Radiotherapy through DNA Damage and Apoptosis Woo SR11, Ham Y2, Kang W3, Yang H3, Kim S4, Jin J3, Joo KM5, Nam DH2.
    View PubMed
  • Mol Cancer. 2014 Sep 12;13:211. doi: 10.1186/1476-4598-13-211. TopBP1 and Claspin contribute to the radioresistance of lung cancer brain metastases Choi SH1, Yang H, Lee SH, Ki JH, Nam DH1, Yoo HY.
    View PubMed
  • J Neurooncol. 2014 Sep;119(2):405-12. doi: 10.1007/s11060-014-1507-1. Epub 2014 Jun 26. Efficacy of postoperative radiotherapy for high grade meningiomas Choi Y11, Lim DH, Jo K, Nam DH, Seol HJ, Lee JI.
    View PubMed
  • Lancet Oncol. 2014 Sep;15(10):1100-8. doi: 10.1016/S1470-2045(14)70379-1. Epub 2014 Aug 19. Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial Stupp R11, Hegi ME2, Gorlia T3, Erridge SC4, Perry J5, Hong YK6, Aldape KD7, Lhermitte B2, Pietsch T8, Grujicic D9, Steinbach JP10, Wick W11, Tarnawski R12, Nam DH13, Hau P14, Weyerbrock A15, Taphoorn MJ16, Shen CC17, Rao N18, Thurzo L19, Herrlinger U8, Gupta T20, Kortmann RD21, Adamska K22, McBain C23, Brandes AA24, Tonn JC25, Schnell O25, Wiegel T26, Kim CY27, Nabors LB28, Reardon DA29, van den Bent MJ30, Hicking C31, Markivskyy A31, Picard M31, Weller M32; European Organisation for Research and Treatment of Cancer (EORTC); Canadian Brain Tumor Consortium; CENTRIC study team.
    View PubMed
  • PLoS One. 2014 Aug 1;9(8):e103327. doi: 10.1371/journal.pone.0103327. eCollection 2014. Translational Validation of Personalized Treatment Strategy Based on Genetic Characteristics of Glioblastoma Oh YT11, Cho HJ1, Kim J2, Lee JH3, Rho K3, Seo YJ4, Choi YS4, Jung HJ4, Song HS4, Kong DS5, Seol HJ5, Lee JI5, Yoon Y1, Kim S3, Nam DH6, Joo KM7.
    View PubMed
  • J Surg Res. 2014 Apr;187(2):502-9. doi: 10.1016/j.jss.2013.11.010. Epub 2013 Nov 15. Colorectal cancer patient-derived xenografted tumors maintain characteristic features of the original tumors Cho YB11, Hong HK1, Choi YL2, Oh E2, Joo KM3, Jin J4, Nam DH4, Ko YH2, Lee WY5.
    View PubMed
  • Acta Neurochir (Wien). 2014 Apr;156(4):641-51. doi: 10.1007/s00701-014-2020-1. Epub 2014 Feb 20. Outcome of conventional treatment and prognostic factor in elderly glioblastoma patients Oh SW11, Jee TK, Kong DS, Nam DH, Lee JI, Seol HJ.
    View PubMed
  • PLoS One. 2014 Mar 19;9(3):e91940. doi: 10.1371/journal.pone.0091940. eCollection 2014. NTRK1 Fusion in Glioblastoma Multiforme Kim J11, Lee Y2, Cho HJ2, Lee YE2, An J2, Cho GH3, Ko YH4, Joo KM5, Nam DH6.
    View PubMed
  • Anal Chem. 2014 Jan 7;86(1):535-42. doi: 10.1021/ac402546b. Epub 2013 Dec 2. High-Throughput Screening (HTS) of Anticancer Drug Efficacy on a Micropillar/Microwell Chip Platform Lee DW11, Choi YS, Seo YJ, Lee MY, Jeon SY, Ku B, Kim S, Yi SH, Nam DH.
    View PubMed
  • Nat Chem Biol. 2014 Jan;10(1):29-34. doi: 10.1038/nchembio.1381. Epub 2013 Nov 10. Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction Kim DG11, Lee JY1, Kwon NH2, Fang P3, Zhang Q4, Wang J3, Young NL5, Guo M3, Cho HY6, Mushtaq AU6, Jeon YH6, Choi JW7, Han JM2, Kang HW8, Joo JE8, Hur Y8, Kang W9, Yang H9, Nam DH9, Lee MS10, Lee JW10, Kim ES11, Moon A11, Kim K2, Kim D2, Kang EJ12, Moon Y12, Rhee KH10, Han BW10, Yang JS13, Han G13, Yang WS2, Lee C14, Wang MW15, Kim S16.
    View PubMed
  • Anticancer Res. 2013 Dec;33(12):5335-42. Genetically-engineered Human Neural Stem Cells with Rabbit Carboxyl Esterase Can Target CNS Lymphoma Kang W11, Jin J, Yang H, Seol HJ, Kim KH, Lee JI, Kim SU, Joo KM, Nam DH.
    View PubMed
  • Mol Cancer Res. 2013 Nov;11(11):1375-86. doi: 10.1158/1541-7786.MCR-13-0101-T. Epub 2013 Aug 27. Tpl2 Kinase Impacts Tumor Growth and Metastasis of Clear Cell Renal Cell Carcinoma Lee HW11, Joo KM, Lim JE, Cho HJ, Cho HJ, Park MC, Seol HJ, Seo SI, Lee JI, Kim S, Jeong BC, Nam DH.
    View PubMed
  • Clin Cancer Res. 2013 Nov 1;19(21):5879-89. doi: 10.1158/1078-0432.CCR-13-1181. Epub 2013 Aug 30. Alpha-Smooth Muscle Actin (ACTA2) Is Required for Metastatic Potential of Human Lung Adenocarcinoma Lee HW11, Park YM, Lee SJ, Cho HJ, Kim DH, Lee JI, Kang MS, Seol HJ, Shim YM, Nam DH, Kim HH, Joo KM.
    View PubMed
  • Clin Exp Metastasis. 2013 Oct;30(7):845-54. doi: 10.1007/s10585-013-9584-7. Epub 2013 Apr 27. Gene silencing of c-Met leads to brain metastasis inhibitory effects Lee SJ11, Seol HJ, Lee HW, Kang WY, Kang BG, Jin J, Jo MY, Jin Y, Lee JI, Joo KM, Nam DH.
    View PubMed
  • Oncol Rep. 2013 Sep;30(3):1101-6. doi: 10.3892/or.2013.2584. Epub 2013 Jul 3. Adenosine potentiates the therapeutic effects of neural stem cells expressing cytosine deaminase against metastatic brain tumors Kang W11, Seol HJ, Seong DH, Kim J, Kim Y, Kim SU, Nam DH, Joo KM.
    View PubMed
  • Neuro Oncol. 2013 Aug;15(8):1096-101. doi: 10.1093/neuonc/not069. Epub 2013 Jun 25. A practical scoring system to determine whether to proceed with surgical resection in recurrent glioblastoma Park CK11, Kim JH, Nam DH, Kim CY, Chung SB, Kim YH, Seol HJ, Kim TM, Choi SH, Lee SH, Heo DS, Kim IH, Kim DG, Jung HW.
    View PubMed
  • Cancer Cell. 2013 Jun 10;23(6):839-52. doi: 10.1016/j.ccr.2013.04.008. Epub 2013 May 16. Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells Kim E11, Kim M, Woo DH, Shin Y, Shin J, Chang N, Oh YT, Kim H, Rheey J, Nakano I, Lee C, Joo KM, Rich JN, Nam DH, Lee J.
    View PubMed
  • Lab Invest. 2013 Mar;93(3):344-53. doi: 10.1038/labinvest.2012.180. Epub 2013 Feb 4. Radiosensitization of brain metastasis by targeting c-MET Yang H11, Lee HW, Kim Y, Lee Y, Choi YS, Kim KH, Jin J, Lee J, Joo KM, Nam DH.
    View PubMed
  • Acta Neurochir (Wien). 2013 Mar;155(3):399-405. doi: 10.1007/s00701-012-1576-x. Epub 2012 Dec 14. Radiosurgery to palliate symptoms in brain metastases from uterine cervix cancer Chung SB11, Jo KI, Seol HJ, Nam DH, Lee JI.
    View PubMed
  • Neuro Oncol. 2013 Feb;15(2):161-71. doi: 10.1093/neuonc/nos299. Epub 2012 Dec 20. Wnt/beta-catenin signaling is a key downstream mediator of MET signaling in glioblastoma stem cells Kim KH11, Seol HJ, Kim EH, Rheey J, Jin HJ, Lee Y, Joo KM, Lee J, Nam DH.
    View PubMed
  • Cancer Discov. 2013 Feb;3(2):198-211. doi: 10.1158/2159-8290.CD-12-0353. Epub 2012 Nov 15. Cancer-Specific Requirement for BUB1B/BUBR1 in Human Brain Tumor Isolates and Genetically Transformed Cells Ding Y11, Hubert CG, Herman J, Corrin P, Toledo CM, Skutt-Kakaria K, Vazquez J, Basom R, Zhang B, Risler JK, Pollard SM, Nam DH, Delrow JJ, Zhu J, Lee J, DeLuca J, Olson JM, Paddison PJ.
    View PubMed
  • Exp Neurol. 2013 Feb;240:168-77. doi: 10.1016/j.expneurol.2012.11.021. Epub 2012 Nov 29. Experimental and clinical factors influencing long-term stable in vitro expansion of multipotent neural cells from human adult temporal lobes Joo KM11, Kang BG, Yeon JY, Cho YJ, An JY, Song HS, Won JH, Kim SJ, Hong SC, Nam DH.
    View PubMed
  • Cancer Lett. 2013 Jan 28;328(2):235-42. doi: 10.1016/j.canlet.2012.09.005. Epub 2012 Sep 27. Blockade of EGFR signaling promotes glioma stem-like cell invasiveness by abolishing ID3-mediated inhibition of p27(KIP1) and MMP3 expression Jin X11, Jin X, Sohn YW, Yin J, Kim SH, Joshi K, Nam DH, Nakano I, Kim H.
    View PubMed
  • Cell Rep. 2013 Jan 31;3(1):260-73. doi: 10.1016/j.celrep.2012.12.013. Epub 2013 Jan 17. Patient-Specific Orthotopic Glioblastoma Xenograft Models Recapitulate the Histopathology and Biology of Human Glioblastomas In Situ Joo KM11, Kim J, Jin J, Kim M, Seol HJ, Muradov J, Yang H, Choi YL, Park WY, Kong DS, Lee JI, Ko YH, Woo HG, Lee J, Kim S, Nam DH.
    View PubMed
  • Int J Oncol. 2012 Dec;41(6):2013-20. doi: 10.3892/ijo.2012.1663. Epub 2012 Oct 15. Genomic copy number alterations associated with the early brain metastasis of non-small cell lung cancer Lee HW11, Seol HJ, Choi YL, Ju HJ, Joo KM, Ko YH, Lee JI, Nam DH.
    View PubMed
  • Mol Cells. 2012 Dec;34(6):523-9. doi: 10.1007/s10059-012-0194-z. Epub 2012 Nov 22. A new anti-c-met antibody selected by a mechanism-based dual-screening method: Therapeutic potential in cancer Oh YM11, Song YJ, Lee SB, Jeong Y, Kim B, Kim GW, Kim KE, Lee JM, Cho MY, Choi J, Nam DH, Song PH, Cheong KH, Kim KA.
    View PubMed
  • Mol Cell Biol. 2012 Oct;32(20):4237-44. Epub 2012 Aug 20. Heterogeneous Nuclear Ribonucleoprotein C1/C2 Controls the Metastatic Potential of Glioblastoma by Regulating PDCD4 Park YM11, Hwang SJ, Masuda K, Choi KM, Jeong MR, Nam DH, Gorospe M, Kim HH.
    View PubMed
  • J Neurosci Res. 2012 Sep;90(9):1794-802. doi: 10.1002/jnr.23063. Epub 2012 Apr 26. Therapeutic effects of human adipose stem cell-conditioned medium on stroke Cho YJ11, Song HS, Bhang S, Lee S, Kang BG, Lee JC, An J, Cha CI, Nam DH, Kim BS, Joo KM.
    View PubMed
  • Mol Cells. 2012 Sep;34(3):329-34. Epub 2012 Sep 3. MicroRNA-146a suppresses metastatic activity in brain metastasis Hwang SJ11, Seol HJ, Park YM, Kim KH, Gorospe M, Nam DH, Kim HH.
    View PubMed
  • Cancer Res. 2012 Aug 1;72(15):3828-38. Epub 2012 May 22. MET Signaling Regulates Glioblastoma Stem Cells Joo KM11, Jin J, Kim E, Ho Kim K, Kim Y, Gu Kang B, Kang YJ, Lathia JD, Cheong KH, Song PH, Kim H, Seol HJ, Kong DS, Lee JI, Rich JN, Lee J, Nam DH.
    View PubMed
  • Mol Med Rep. 2012 Jul;6(1):88-92. doi: 10.3892/mmr.2012.868. Epub 2012 Apr 11. Combined therapy of temozolomide and ZD6474 (vandetanib) effectively reduces glioblastoma tumor volume through anti-angiogenic and anti-proliferative mechanisms Jo MY11, Kim YG, Kim Y, Lee SJ, Kim MH, Joo KM, Kim HH, Nam DH.
    View PubMed
  • Int J Oncol. 2012 Apr;40(4):1122-32. doi: 10.3892/ijo.2011.1302. Epub 2011 Dec 15. Identification of prognostic biomarkers for glioblastomas using protein expression profiling Jung Y11, Joo KM, Seong DH, Choi YL, Kong DS, Kim Y, Kim MH, Jin J, Suh YL, Seol HJ, Shin CS, Lee JI, Kim JH, Song SY, Nam DH.
    View PubMed
  • Brain. 2012 Apr;135(Pt 4):1055-69. doi: 10.1093/brain/aws028. Epub 2012 Mar 20. Interferon regulatory factor 7 regulates glioma stem cells via interleukin-6 and Notch signalling Jin X11, Kim SH, Jeon HM, Beck S, Sohn YW, Yin J, Kim JK, Lim YC, Lee JH, Kim SH, Kang SH, Pian X, Song MS, Park JB, Chae YS, Chung YG, Lee SH, Choi YJ, Nam DH, Choi YK, Kim H.
    View PubMed
  • Lab Invest. 2012 Mar;92(3):466-73. doi: 10.1038/labinvest.2011.161. Epub 2011 Nov 14. Wnt activation is implicated in glioblastoma radioresistance Kim Y11, Kim KH, Lee J, Lee YA, Kim M, Lee SJ, Park K, Yang H, Jin J, Joo KM, Lee J, Nam DH.
    View PubMed
  • Biochem Biophys Res Commun. 2012 Feb 10;418(2):359-65. doi: 10.1016/j.bbrc.2012.01.026. Epub 2012 Jan 17. Replacement of microglial cells using Clodronate liposome and bone marrow transplantation in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis Lee JC11, Seong J, Kim SH, Lee SJ, Cho YJ, An J, Nam DH, Joo KM, Cha CI.
    View PubMed
  • PLoS One. 2012;7(2):e25936. doi: 10.1371/journal.pone.0025936. Epub 2012 Feb 10. Trans-Differentiation of Neural Stem Cells: A Therapeutic Mechanism Against the Radiation Induced Brain Damage Joo KM11, Jin J, Kang BG, Lee SJ, Kim KH, Yang H, Lee YA, Cho YJ, Im YS, Lee DS, Lim DH, Kim DH, Um HD, Lee SH, Lee JI, Nam DH.
    View PubMed
  • Bioconjug Chem. 2011 Dec 21;22(12):2568-72. doi: 10.1021/bc200406n. Epub 2011 Nov 28. In Vivo Specific Delivery of c-Met siRNA to Glioblastoma Using Cationic Solid Lipid Nanoparticles Jin J11, Bae KH, Yang H, Lee SJ, Kim H, Kim Y, Joo KM, Seo SW, Park TG, Nam DH.
    View PubMed
  • 없음 Mild generation of selenolate nucleophiles by thiol reduction of diselenides: convenient syntheses of selenyl-substituted aryl aldehydes
  • Cancer Lett. 2011 Dec 8;311(2):152-9. doi: 10.1016/j.canlet.2011.07.001. Epub 2011 Jul 14. Genetically engineered human neural stem cells with rabbit carboxyl esterase can target brain metastasis from breast cancer Seol HJ11, Jin J, Seong DH, Joo KM, Kang W, Yang H, Kim J, Shin CS, Kim Y, Kim KH, Kong DS, Lee JI, Aboody KS, Lee HJ, Kim SU, Nam DH.
    View PubMed
  • Cancer Res. 2011 Nov 15;71(22):7125-34. doi: 10.1158/0008-5472.CAN-11-1330. Epub 2011 Oct 5. EGFR-AKT-Smad Signaling Promotes Formation of Glioma Stem-like Cells and Tumor Angiogenesis by ID3-Driven Cytokine Induction Jin X11, Yin J, Kim SH, Sohn YW, Beck S, Lim YC, Nam DH, Choi YJ, Kim H.
    View PubMed
  • Biomaterials. 2011 Nov;32(33):8518-28. doi: 10.1016/j.biomaterials.2011.07.048. Epub 2011 Aug 30. Identification of a peptide that interacts with Nestin protein expressed in brain cancer stem cells Beck S11, Jin X, Yin J, Kim SH, Lee NK, Oh SY, Jin X, Kim MK, Kim EB, Son JS, Kim SC, Nam DH, Kim SH, Kang SK, Kim H, Choi YJ.
    View PubMed
  • Oncol Res. 2011;19(8-9):381-90. The Expression of DNA Damage Checkpoint Proteins and Prognostic Implication in Metastatic Brain Tumors Seol HJ11, Yoo HY, Jin J, Joo KM, Kim HS, Yoon SJ, Choi SH, Kim Y, Pyo HR, Lim DH, Kim W, Um HD, Kim JH, Lee JI, Nam DH.
    View PubMed
  • Oncol Rep. 2011 Aug;26(2):423-30. doi: 10.3892/or.2011.1325. Epub 2011 May 26. Prognostic implications of the DNA damage response pathway in glioblastoma Seol HJ11, Yoo HY, Jin J, Joo KM, Kong DS, Yoon SJ, Yang H, Kang W, Lim DH, Park K, Kim JH, Lee JI, Nam DH.
    View PubMed
  • Exp Mol Med. 2011 Jul 30;43(7):419-26. doi: 10.3858/emm.2011.43.7.046. Time-course analysis of DNA damage response-related genes after in vitro radiation in H460 and H1229 lung cancer cell lines Kim KH11, Yoo HY, Joo KM, Jung Y, Jin J, Kim Y, Yoon SJ, Choi SH, Seol HJ, Park WY, Nam do H.
    View PubMed
  • J Neurooncol. 2011 Jul;103(3):595-602. doi: 10.1007/s11060-010-0427-y. Epub 2010 Nov 4. Radiotherapy followed by adjuvant temozolomide with or without neoadjuvant ACNU-CDDP chemotherapy in newly diagnosed glioblastomas: a prospective randomized controlled multicenter phase III trial Kim IH11, Park CK, Heo DS, Kim CY, Rhee CH, Nam DH, Lee SH, Han JH, Lee SH, Kim TM, Kim DW, Kim JE, Paek SH, Kim DG, Kim IA, Kim YJ, Kim JH, Park BJ, Jung HW.
    View PubMed
  • Mol Ther. 2011 Jun;19(6):1161-9. doi: 10.1038/mt.2011.28. Epub 2011 Mar 8. hMSC-mediated Concurrent Delivery of Endostatin and Carboxylesterase to Mouse Xenografts Suppresses Glioma Initiation and Recurrence Yin J11, Kim JK, Moon JH, Beck S, Piao D, Jin X, Kim SH, Lim YC, Nam DH, You S, Kim H, Choi YJ.
    View PubMed
  • Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model
  • Cancer Res. 2011 Apr 15;71(8):3066-75. doi: 10.1158/0008-5472.CAN-10-1495. Epub 2011 Mar 1. Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation Jin X11, Jeon HY, Joo KM, Kim JK, Jin J, Kim SH, Kang BG, Beck S, Lee SJ, Kim JK, Park AK, Park WY, Choi YJ, Nam DH, Kim H.
    View PubMed
  • Biochem Biophys Res Commun. 2011 Mar 4;406(1):53-8. doi: 10.1016/j.bbrc.2011.01.106. Epub 2011 Feb 1. Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy Yang H11, Yoon SJ, Jin J, Choi SH, Seol HJ, Lee JI, Nam DH, Yoo HY.
    View PubMed
  • Mol Cells. 2010 Nov;30(5):403-8. doi: 10.1007/s10059-010-0122-z. Epub 2010 Aug 31. The Neural Stem Cell Fate Determinant TLX Promotes Tumorigenesis and Genesis of Cells Resembling Glioma Stem Cells (vol 30, pg 403, 2010) Park HJ11, Kim JK, Jeon HM, Oh SY, Kim SH, Nam DH, Kim H.
    View PubMed
  • AJNR Am J Neuroradiol. 2011 Feb;32(2):382-7. doi: 10.3174/ajnr.A2286. Epub 2011 Jan 20. Diagnostic Dilemma of Pseudoprogression in the Treatment of Newly Diagnosed Glioblastomas: The Role of Assessing Relative Cerebral Blood Flow Volume and Oxygen-6-Methylguanine-DNA Methyltransferase Promoter Methylation Status Kong DS11, Kim ST, Kim EH, Lim DH, Kim WS, Suh YL, Lee JI, Park K, Kim JH, Nam DH.
    View PubMed
  • Oncol Rep. 2011 Jan;25(1):33-9. Synergistic therapeutic effects of cytokine-induced killer cells and temozolomide against glioblastoma Jin J11, Joo KM, Lee SJ, Jo MY, Kim Y, Jin Y, Kim JK, Ahn JM, Yoon MJ, Lim J, Nam DH.
    View PubMed
  • Mol Cells. 2011 Jan;31(1):9-15. doi: 10.1007/s10059-011-0008-8. Epub 2010 Dec 24. Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression Beck S11, Jin X, Sohn YW, Kim JK, Kim SH, Yin J, Pian X, Kim SC, Nam DH, Choi YJ, Kim H.
    View PubMed
  • Neurol Res. 2011 Jan;33(1):33-7. doi: 10.1179/016164110X12807570509899. Epub 2010 Aug 31. Functional neural stem cell isolation from brains of adult mutant SOD1 (SOD1(G93A)) transgenic amyotrophic lateral sclerosis (ALS) mice Lee JC11, Jin Y, Jin J, Kang BG, Nam DH, Joo KM, Cha CI.
    View PubMed
  • Oncol Rep. 2011 Jan;25(1):63-8. Combined treatment of tumor-tropic human neural stem cells containing the CD suicide gene effectively targets brain tumors provoking a mild immune response Lee SJ11, Kim Y, Jo MY, Kim HS, Jin Y, Kim SU, Jin J, Joo KM, Nam DH.
    View PubMed
  • Cancer Res. 2010 Dec 15;70(24):10411-21. doi: 10.1158/0008-5472.CAN-10-2591. Epub 2010 Nov 5. CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche Kim M11, Koh YJ, Kim KE, Koh BI, Nam DH, Alitalo K, Kim I, Koh GY.
    View PubMed
  • Cancer Res. 2010 Dec 1;70(23):9730-41. doi: 10.1158/0008-5472.CAN-10-1882. Epub 2010 Nov 23. Negative Regulation of p53 by the Long Isoform of ErbB3 Binding Protein Ebp1 in Brain Tumors Kim CK11, Nguyen TL, Joo KM, Nam DH, Park J, Lee KH, Cho SW, Ahn JY.
    View PubMed
  • Treatment of atypical meningioma
  • Exp Ther Med. 2010 Nov;1(6):943-946. Epub 2010 Aug 26. Schedule-dependent synergistic effect of rituximab on methotrexate chemotherapy against lymphoma of the central nervous system Jin J11, Joo KM, Nam Y, Kim DH, Lee SJ, Jo MY, Jin Y, Kim HS, Seo SW, Kim SJ, Nam DH, Kim WS.
    View PubMed
  • Mol Cells. 2010 Nov;30(5):403-8. doi: 10.1007/s10059-010-0122-z. Epub 2010 Aug 31. The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells Park HJ11, Kim JK, Jeon HM, Oh SY, Kim SH, Nam DH, Kim H.
    View PubMed
  • Cancer Cell. 2010 Aug 9;18(2):171-84. doi: 10.1016/j.ccr.2010.07.001. Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage Koh YJ11, Kim HZ, Hwang SI, Lee JE, Oh N, Jung K, Kim M, Kim KE, Kim H, Lim NK, Jeon CJ, Lee GM, Jeon BH, Nam DH, Sung HK, Nagy A, Yoo OJ, Koh GY.
    View PubMed
  • BMC Cancer. 2010 Aug 13;10:424. doi: 10.1186/1471-2407-10-424. Impact of adjuvant chemotherapy for gliomatosis cerebri Kong DS11, Kim ST, Lee JI, Suh YL, Lim do H, Kim WS, Kwon KH, Park K, Kim JH, Nam DH.
    View PubMed
  • Neuro Oncol. 2010 Mar;12(3):289-96. doi: 10.1093/neuonc/nop030. Epub 2010 Jan 11. Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma Kong DS11, Lee JI, Kim JH, Kim ST, Kim WS, Suh YL, Dong SM, Nam DH.
    View PubMed
  • Clin Neurol Neurosurg. 2009 Nov;111(9):748-51. doi: 10.1016/j.clineuro.2009.07.014. Epub 2009 Aug 28. Efficacy of temozolomide as adjuvant chemotherapy after postsurgical radiotherapy alone for glioblastomas Rhee DJ11, Kong DS, Kim WS, Park KB, Lee JI, Suh YL, Song SY, Kim ST, Lim DH, Park K, Kim JH, Nam DH.
    View PubMed
  • Clin Neurol Neurosurg. 2009 Oct;111(8):679-82. doi: 10.1016/j.clineuro.2009.06.013. Epub 2009 Jul 28. Clinical outcome of concomitant chemoradiotherapy followed by adjuvant temozolomide therapy for glioblastaomas: Single-center experience Jeon HJ11, Kong DS, Park KB, Lee JI, Park K, Kim JH, Kim ST, Lim do H, Kim WS, Nam DH.
    View PubMed
  • Cell Stem Cell. 2009 May 8;4(5):440-52. doi: 10.1016/j.stem.2009.03.003. SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma Son MJ11, Woolard K, Nam DH, Lee J, Fine HA.
    View PubMed
  • Mol Ther. 2009 Mar;17(3):570-5. doi: 10.1038/mt.2008.290. Epub 2009 Jan 6. Human Neural Stem Cells Can Target and Deliver Therapeutic Genes to Breast Cancer Brain Metastases Joo KM11, Park IH, Shin JY, Jin J, Kang BG, Kim MH, Lee SJ, Jo MY, Kim SU, Nam DH.
    View PubMed
  • Cancer. 2009 Jan 1;115(1):140-8. doi: 10.1002/cncr.23972. Prognostic Significance of c-Met Expression in Glioblastomas Kong DS11, Song SY, Kim DH, Joo KM, Yoo JS, Koh JS, Dong SM, Suh YL, Lee JI, Park K, Kim JH, Nam DH.
    View PubMed
  • Int J Oncol. 2008 Oct;33(4):705-12. Response of brain specific microenvironment to P-glycoprotein inhibitor: An important factor determining therapeutic effect of P-glycoprotein inhibitor on brain metastatic tumors Joo KM11, Song SY, Park K, Kim MH, Jin J, Kang BG, Jang MJ, Lee GS, Kim MS, Nam DH.
    View PubMed
  • Lab Invest. 2008 Aug;88(8):808-15. doi: 10.1038/labinvest.2008.57. Epub 2008 Jun 16. Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas Joo KM11, Kim SY, Jin X, Song SY, Kong DS, Lee JI, Jeon JW, Kim MH, Kang BG, Jung Y, Jin J, Hong SC, Park WY, Lee DS, Kim H, Nam DH.
    View PubMed
  • Genes Dev. 2008 Aug 1;22(15):2028-33. doi: 10.1101/gad.1668708. Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling Jeon HM11, Jin X, Lee JS, Oh SY, Sohn YW, Park HJ, Joo KM, Park WY, Nam DH, DePinho RA, Chin L, Kim H.
    View PubMed
  • Clin Cancer Res. 2008 Jul 1;14(13):4059-66. doi: 10.1158/1078-0432.CCR-07-4039. Activation of Notch signaling in a xenograft model of brain metastasis Nam DH11, Jeon HM, Kim S, Kim MH, Lee YJ, Lee MS, Kim H, Joo KM, Lee DS, Price JE, Bang SI, Park WY.
    View PubMed
  • J Clin Neurosci. 2008 Jun;15(6):721-2; author reply 722-3. doi: 10.1016/j.jocn.2007.08.031. Epub 2008 Apr 10. Reply to letter regarding Tc-99m-Tetrofosmin SPECT for the assessment of meningioma malignancy Alexiou GA1, Tsiouris S, Goussia A, Polyzoidis KS, Fotopoulos AD, Kyritsis AP.
    View PubMed
  • Mol Med Rep. 2008 May-Jun;1(3):343-6. Antitumor activity of ZD6474 in a metastatic orthotopic brain tumor model Kong DS11, Kim MH, Jeon JW, Kim SY, Kim MS, Joo KM, Park K, Nam DH.
    View PubMed
  • Cancer. 2008 May 1;112(9):2046-51. doi: 10.1002/cncr.23402. Efficacy of stereotactic radiosurgery as a salvage treatment for recurrent malignant gliomas Kong DS11, Lee JI, Park K, Kim JH, Lim DH, Nam DH.
    View PubMed
  • Oncol Rep. 2008 Mar;19(3):639-43. The progression of gliomas is associated with cancer stem cell phenotype Kong DS11, Kim MH, Park WY, Suh YL, Lee JI, Park K, Kim JH, Nam DH.
    View PubMed
  • Oncol Rep. 2008 Jan;19(1):17-23. Oral paclitaxel chemotherapy for brain tumors: Ideal combination treatment of paclitaxel and P-glycoprotein inhibitor Joo KM11, Park K, Kong DS, Song SY, Kim MH, Lee GS, Kim MS, Nam DH.
    View PubMed
  • J Clin Neurosci. 2007 Aug;14(8):747-53. Epub 2007 May 17. Relationship between malignant subtypes of meningioma and clinical outcome Ko KW11, Nam DH, Kong DS, Lee JI, Park K, Kim JH.
    View PubMed
  • Headache. 2007 Feb;47(2):199-203. Atypical spontaneous intracranial hypotension (SIH) with nonorthostatic headache Kong DS11, Park K, Nam DH, Lee JI, Kim ES, Kim JS, Hong SC, Shin HJ, Eoh W, Kim JH.
    View PubMed
  • J Phys Chem B. 2012 Nov 8;116(44):13228-38. doi: 10.1021/jp3032918. Epub 2012 Oct 30. Development of a T-1 contrast agent for magnetic resonance imaging using MnO nanoparticles L?tourneau M11, Tremblay M, Faucher L, Rojas D, Chevallier P, Gossuin Y, Lagueux J, Fortin MA.
    View PubMed
  • J Neurosurg. 2006 Dec;105 Suppl:139-43. Preservation of quality of life by preradiotherapy stereotactic radiosurgery for unresectable glioblastoma multiforme Kong DS11, Nam DH, Lee JI, Park K, Kim JH.
    View PubMed
  • Oncol Rep. 2006 Nov;16(5):1117-21. A pilot study of metronomic temozolomide treatment in patients with recurrent temozolomide-refractory glioblastoma Kong DS11, Lee JI, Kim WS, Son MJ, Lim do H, Kim ST, Park K, Kim JH, Eoh W, Nam DH.
    View PubMed
  • Oncol Rep. 2006 Jul;16(1):33-9. Metronomic treatment of temozolomide inhibits tumor cell growth through reduction of angiogenesis and augmentation of apoptosis in orthotopic models of gliomas Kim JT11, Kim JS, Ko KW, Kong DS, Kang CM, Kim MH, Son MJ, Song HS, Shin HJ, Lee DS, Eoh W, Nam DH.
    View PubMed
  • Int J Oncol. 2006 Jun;28(6):1385-92. Synergistic effect and condition of pegylated interferon a with paclitaxel on glioblastoma Son MJ11, Song HS, Kim MH, Kim JT, Kang CM, Jeon JW, Park SY, Kim YJ, Groves MD, Park K, Kim JH, Nam DH.
    View PubMed
  • Oncol Rep. 2006 May;15(5):1163-8. Antiangiogenic agent, thalidomide increases the antitumor effect of single high dose irradiation (gamma knife radiosurgery) in the rat orthotopic glioma model Lee JI11, Itasaka S, Kim JT, Nam DH.
    View PubMed
  • Oncol Rep. 2006 Jan;15(1):7-13. Combination celecoxib and temozolomide in C6 rat glioma orthotopic model Kang SG11, Kim JS, Park K, Kim JS, Groves MD, Nam DH.
    View PubMed
  • Int J Oncol. 2006 Jan;28(1):53-9. Combination treatment with temozolomide and thalidomide inhibits tumor growth and angiogenesis in an orthotopic glioma model Son MJ11, Kim JS, Kim MH, Song HS, Kim JT, Kim H, Shin T, Jeon HJ, Lee DS, Park SY, Kim YJ, Kim JH, Nam DH.
    View PubMed
  • Neurol Med Chir (Tokyo). 2005 May;45(5):232-8; discussion 238-9. Clinical and radiological prognostic factors of anaplastic oligodendroglioma treated by combined therapy Kang SG11, Kim JH, Nam DH, Park K.
    View PubMed
  • Oncol Rep. 2004 Apr;11(4):863-9. Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: prognostic significance Nam DH11, Park K, Suh YL, Kim JH.
    View PubMed
  • Oncol Rep. 2004 Feb;11(2):263-8. Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib Nam DH11, Park K, Park C, Im YH, Kim MH, Lee S, Hong SC, Shin HJ, Kim JH, Eoh W, McDonnell TJ.
    View PubMed
  • Neurosci Lett. 2001 Oct 12;312(1):41-4. Expression of interleukin-1 beta in lipopolysaccharide stimulated monocytes derived from patients with aneurysmal subarachnoid hemorrhage is correlated with cerebral vasospasm Nam DH11, Kim JS, Hong SC, Lee WH, Lee JI, Shin HJ, Park K, Eoh W, Han DH, Kim JH.
    View PubMed
  • Exp Mol Med. 2001 Sep 30;33(3):111-6. Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas Nam DH11, Song SY, Park K, Kim MH, Suh YL, Lee JI, Kim JS, Hong SC, Shin HJ, Park K, Eoh W, Kim JH.
    View PubMed
  • Int J Oncol. 2001 Jan;18(1):111-6. The detection of p53 gene mutation using a microdissection technique in primary intracranial germ cell tumors Kim SK11, Cho BK, Paek SH, Hong SJ, Kim HS, Hong SY, Choe G, Chi JG, Nam DH, Wang KC.
    View PubMed
  • J Korean Med Sci. 2000 Aug;15(4):452-6. The effect of isochromosome 17q presence, proliferative and apoptotic indices, expression of c-erbB-2, bcl-2 and p53 proteins on the prognosis of medulloblastoma Nam DH11, Wang KC, Kim YM, Chi JG, Kim SK, Cho BK.
    View PubMed
  • Neurosci Lett. 2000 Mar 31;283(1):45-8. Vascular endothelial growth factor expression under ischemic stress in human meningiomas Park K11, Kim JH, Nam DH, Lee JI, Kim JS, Hong SC, Shin HJ, Eoh W, Park K.
    View PubMed
  • Childs Nerv Syst. 1999 Apr;15(4):179-84. A simple method of predicting hormonal outcome in children with intracranial germinoma Nam DH11, Wang KC, Shin CH, Yang SW, Cho BK.
    View PubMed
  • Childs Nerv Syst. 1999 Apr;15(4):185-91. Treatment of intracranial nongerminomatous malignant germ cell tumor in children: the role of each treatment modality Nam DH11, Cho BK, Shin HJ, Ahn HS, Kim IH, Wang KC.
    View PubMed