신경외과 남도현 교수

Ko En

신경외과 남도현 교수

진료분야: 뇌하수체종양, 뇌교종, 전이성뇌종양, 악성뇌종양

진료일정 04 月

날짜		월 01	화 02	수 03	목 04	금 05	토 06	일 07	월 08	화 09	수 10	목 11	금 12	토 13	일 14	월 15	화 16	수 17	목 18	금 19	토 20	일 21	월 22	화 23	수 24	목 25	금 26	토 27	일 28	월 29	화 30
오전
오후

진료일정 05 月

날짜				수 01	목 02	금 03	토 04	일 05	월 06	화 07	수 08	목 09	금 10	토 11	일 12	월 13	화 14	수 15	목 16	금 17	토 18	일 19	월 20	화 21	수 22	목 23	금 24	토 25	일 26	월 27	화 28	수 29	목 30	금 31
오전
오후

학력

학력
2001.02	서울대학교 대학원 의학과 (박사)
1997.02	서울대학교 대학원 의학과 (석사)
1988.02	서울대학교 의과대학 졸업 (의학사)

경력

경력
2009.12 ~현재	삼성 난치암 연구사업단 단장
2009.04 ~현재	성균관의대 신경외과학교실 교수
1998.03 ~현재	삼성서울병원 신경외과 전문의
2013.03 ~ 2017.02	삼성 융합의과학과 과장
2003.04 ~ 2009.03	성균관의대 신경외과학교실 부교수
2002.02 ~ 2004.01	미국 Univ. of Texas MD Anderson Cancer Center 연구원
1999.03 ~ 2003.03	성균관의대 신경외과학교실 조교수
1997.03 ~ 1998.02	삼성서울병원 신경외과 전임의
1996.05 ~ 1997.02	서울대학병원 신경외과 전임의
1989.03 ~ 1993.02	서울대학교병원 신경외과 레지던트 과정 수료
1988.03 ~ 1989.02	서울대학교병원 인턴 과정 수료

연구분야

연구분야
뇌종양 개인 맞춤 치료(아바타) 및 유전체 연구
본 연구실은 암환자에게 최적의 치료 솔루션을 제시할 수 있는 개인 맞춤 의학 실현을 위해 환자와 유전체 정보 및 약물정보를 연결해주는 인터페이스 개발을 목표로 연구하고 있다. 이를 위하여 암줄기세포를 표적으로 하여 특정 신호전달체계와 유전자 발현의 특성에 대한 연구를 진행하고 있으며, 특히 교모세포종 환자로부터 암줄기세포를 분리하여 배양하는 방법을 국내 최초로 확립하였다. 환자 유래 샘플 라이브러리를 통한 아바타 모델을 확립하여 유전체 기반 개인 맞춤 치료 플랫폼을 구축하였고 암 환자에게 최적의 치료 솔루션을 제공할 수 있는 인터페이스 역할인 아바타 스캔 시스템을 개발 중이다.
뇌하수체 종양 내시경 수술기법 연구
뇌하수체 종양은 전체 뇌종양의 10~15%의 빈도를 차지하고 있는 질환으로, 해부학적 위치의 특성상 두개절개술로 접근하기에 여러 가지 어려움이 있습니다. 이에 대한 수술적 접근을 위해 경접형동 접근법(Trans-sphenoidal approach)를 통한 현미경적 수술이 과거부터 사용되어 왔으나, 수술시야에서 한계가 많아 적용범위가 제한적이었습니다. 최근 장비의 발전과 여러 수술법의 개발로 내시경을 이용한 경접형동 접근법 수술이 증가하는 추세이며, 이 방법을 이용하여 뇌하수체 선종 뿐 아니라 두개인두종, 척삭종 및 터키안결절 부위에서 발생한 뇌수종까지 적용범위가 늘어나고 있습니다. 그러나 내시경을 이용한 경접형동 접근법 수술법을 시행하게 되면 현미경적 수술법에 비해 코점막의 손상이 크고 수술 후 후각기능의 저하가 심하다는 것과 뇌척수액 누출의 위험성이 상대적으로 높다는 치명적인 단점이 있습니다. 이에 이비인후과와 협진하여 코점막의 손상을 최소화하면서도 안전하고 효과적인 내시경 수술기법을 시행하기 위한 여러 가지 연구를 진행하고 있습니다.

논문

CANCERS 2024 10.3390/cancers16010064 Treatment Outcomes after Dose-Escalated Moderately Hypofractionated Radiotherapy for Frail Patients with High-Grade Glioma Kim, N; Shin, H; Lim, D; Nam, D; Lee, JI; Seol, HJ; Kong, DS; Choi, JW; Chong, KYH; Lee, WJ
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JCI INSIGHT 2023 10.1172/jci.insight.167049 The semaphorin 3A/neuropilin-1 pathway promotes clonogenic growth of glioblastoma via activation of TGF-β signaling Jeon, HM; Shin, YJ; Lee, J; Chang, N; Woo, DH; Lee, WJ; Nguyen, D; Kang, W; Cho, HJ; Yang, H; Lee, JK; Sa, JK; Lee, Y; Kim, DG; Purow, BW; Yoon, Y; Nam, D; Lee, JW
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J NEURO-ONCOL 2023 10.1007/s11060-023-04465-6 Impact of boost sequence in concurrent chemo-radiotherapy on newly diagnosed IDH-wildtype glioblastoma multiforme Kim, N; Lee, J; Nam, D; Lee, JI; Seol, HJ; Kong, DS; Choi, JW; Chong, K; Lee, WJ; Chang, JH; Kang, SG; Moon, JH; Cho, J; Lim, D; Yoon, HI
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SCI TRANSL MED 2023 10.1126/scitranslmed.adh4181 Identifying predictors of glioma evolution from longitudinal sequencing Mu, QH; Chai, RC; Pang, B; Yang, YX; Liu, HJ; Zhao, Z; Bao, ZS; Song, D; Zhu, ZH; Yan, ML; Jiang, BB; Mo, ZC; Tang, JH; Sa, JK; Cho, HJ; Chang, YZ; Chan, KHY; Loi, DSC; Tam, SST; Chan, AKY; Wu, AR; Liu, ZQ; Poon, WS; Ng, HK; Chan, DTM; Iavarone, A; Nam, D; Jiang, T; Wang, JG
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J KOREAN NEUROSURG S 2023 10.3340/jkns.2022.0229 Effect of Bevacizumab Treatment in Cerebral Radiation Necrosis : Investigation of Response Predictors in a Single-Center Experience Lee, SH; Choi, JW; Kong, DS; Seol, HJ; Nam, DH; Lee, JI
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CANCER MED-US 2023 10.1002/cam4.6213 A multicenter, phase II trial of GC1118, a novel anti-EGFR antibody, for recurrent glioblastoma patients with EGFR amplification Choi, SW; Jung, HA; Cho, HJ; Kim, TM; Park, CK; Nam, D; Lee, SH
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CANCER CELL 2023 10.1016/j.ccell.2023.06.007 Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling Jeon, HM; Kim, JY; Cho, HJ; Lee, WJ; Nguyen, D; Kim, SS; Oh, YT; Kim, HJ; Hubert, CG; Jung, CW; Pinero, G; Joshi, T; Sakaguchi, T; Hambardzumyan, D; Mcintyre, TM; Fine, HA; Gladson, CL; Wang, BC; Purow, BW; Park, JB; Park, MJ; Nam, D; Lee, J
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ADV THER-GERMANY 2023 10.1002/adtp.202300148 Translational mRNA Profiling Analysis of Pseudopalisading Cells in Bevacizumab Resistance of GBM Kim, Y; Kim, TH; Sreynet, S; Oh, YS; Nam, D; Park, JB; Kim, SS
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DISCOV ONCOL 2023 10.1007/s12672-023-00678-3 Efficacy and safety of metformin plus low-dose temozolomide in patients with recurrent or refractory glioblastoma: a randomized, prospective, multicenter, double-blind, controlled, phase 2 trial (KNOG-1501 study) Yoon, WS; Chang, JH; Kim, JH; Kim, YJ; Jung, TY; Yoo, H; Kim, SH; Ko, YC; Nam, DH; Kim, TM; Kim, SH; Park, SH; Lee, YS; Yim, HW; Hong, YK; Yang, SH
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ADV THER-GERMANY 2023 10.1002/adtp.202300067 The Regulatory Roles of Mitochondrial Metabolism Dynamics and Mitochondria Calcium Uniporter (MCU) in Bevacizumab Resistance of GBM Kim, Y; Kwak, C; Park, JB; Nam, D; Rhee, HW; Kim, SS
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YONSEI MED J 2023 10.3349/ymj.2022.0352 Clinical Outcomes of Moderately Hypofractionated Concurrent Chemoradiotherapy for Newly Diagnosed Glioblastoma Kim, N; Lim, DH; Choi, JW; Lee, JI; Kong, DS; Nam, DH; Seol, HJ
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WORLD NEUROSURG 2022 10.1016/j.wneu.2022.10.067 Impact of Postural Changes on Sinonasal Pressure After Endoscopic Endonasal Surgery Choi, HW; Choi, JW; Seol, HJ; Nam, D; Lee, JI; Kong, DS
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J CLIN MED 2022 10.3390/jcm11226711 Comparison of Graft Materials in Multilayer Reconstruction with Nasoseptal Flap for High-Flow CSF Leak during Endoscopic Skull Base Surgery Kim, BK; Kong, DS; Nam, DH; Hong, SD
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WORLD NEUROSURG 2022 10.1016/J.WNEu.2022.04.088 Factors Associated with Acute Obstructive Hydrocephalus After Retrosigmoid Approach for Extra-Axial Cerebellopontine Angle Tumors Lee, WJ; Choi, JW; Kong, DS; Nam, D; Lee, JI; Seol, HJ
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BIOCHEM BIOPH RES CO 2022 10.1016/j.bbrc.2022.07.107 Functional validation of the simplified in vitro 3D Co-culture based BBB model Kim, W; Kim, J; Lee, SY; Kim, HM; Jung, HT; Joo, KM; Nam, D
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ADV SCI 2022 10.1002/advs.202201785 Recapitulated Crosstalk between Cerebral Metastatic Lung Cancer Cells and Brain Perivascular Tumor Microenvironment in a Microfluidic Co-Culture Chip Kim, H; Sa, JK; Kim, J; Cho, HJ; Oh, HJ; Choi, DH; Kong, SH; Jeong, D; Nam, DH; Lee, H; Lee, HW; Chung, S
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BIOCHEM BIOPH RES CO 2022 10.1016/j.bbrc.2022.06.083 Simplified in vitro 3D co-culture-based blood-brain barrier model using transwell Kim, W; Kim, J; Lee, SY; Kim, HM; Joo, KM; Nam, D
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SCI REP-UK 2022 10.1038/s41598-022-13853-3 Clinical outcomes of patients with multiple courses of radiosurgery for brain metastases from non-small cell lung cancer Lee, WJ; Choi, JW; Kong, DS; Seol, HJ; Nam, DH; Lee, JI
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FRONT ONCOL 2022 10.3389/fonc.2022.906162 Clinical Impact of Hydroxyapatite on the Outcome of Skull Base Reconstruction for Intraoperative High-Flow CSF Leak: A Propensity Score Matching Analysis Lee, SH; Ha, CM; Hong, SD; Choi, JW; Seol, HJ; Nam, D; Lee, JI; Kong, DS
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CANCER RES TREAT 2022 10.4143/crt.2021.393 Influence of Concurrent and Adjuvant Temozolomide on Health-Related Quality of Life of Patients with Grade III Gliomas: A Secondary Analysis of a Randomized Clinical Trial (KNOG-1101 Study) Ahn, GS; Hwang, K; Kim, TM; Park, CK; Chang, JH; Jung, TY; Kim, JH; Nam, DH; Kim, SH; Yoo, H; Hong, YK; Kim, EY; Lee, DE; Joo, J; Kim, YJ; Choe, G; Choi, BS; Kang, SG; Kim, JH; Kim, CY
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ACTA NEUROCHIR 2022 10.1007/s00701-022-05203-z Combined endoscopic endonasal and transorbital multiportal approach for complex skull base lesions involving multiple compartments Lee, WJ; Hong, SD; Woo, KI; Seol, HJ; Choi, JW; Lee, JI; Nam, DH; Kong, DS
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WORLD NEUROSURG 2022 10.1016/j.wneu.2021.12.074 Serum Prolactin Level to Tumor Size Ratio as a Potential Parameter for Preoperative Differentiation of Prolactinomas from Hyperprolactinemia-Causing Non-functional Pituitary Adenomas Kim, JH; Hur, KY; Hong, SD; Choi, JW; Seol, HJ; Nam, DH; Lee, JI; Kong, DS
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WORLD NEUROSURG 2022 10.1016/j.wneu.2021.10.169 Treatment Strategy for Giant Solid Hemangioblastomas in the Posterior Fossa: A Retrospective Review of 13 Consecutive Cases Jeon, C; Choi, JW; Kong, DS; Nam, DH; Lee, JI; Seol, HJ
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SCI REP-UK 2022 10.1038/s41598-022-06881-6 Histopathology and surgical outcome of symptomatic treatment-related changes after gamma knife radiosurgery in patients with brain metastases Kim, JH; Choi, JW; Kong, DS; Seol, HJ; Nam, D; Ryu, JW; Kim, ST; Suh, YL; Lee, JI
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J NEUROSURG 2022 10.3171/2021.2.JNS203867 Endoscopic endonasal and transorbital approaches to petrous apex lesions Lee, WJ; Hong, SD; Woo, KI; Seol, HJ; Choi, JW; Lee, JI; Nam, DH; Kong, DS
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WORLD NEUROSURG 2022 10.1016/j.wneu.2021.11.003 Graded Reconstruction Strategy Using a Multilayer Technique Without Lumbar Drainage After Endoscopic Endonasal Surgery Ha, CM; Hong, SD; Choi, JW; Seol, HJ; Nam, DH; Lee, JI; Kong, DS
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J NEURO-ONCOL 2022 10.1007/s11060-021-03930-4 Bevacizumab plus irinotecan with or without gamma knife radiosurgery after failure of concurrent chemo-radiotherapy for high-grade glioma Lee, YP; Jung, HA; Lee, MS; Choi, JW; Kong, DS; Seol, HJ; Nam, DH; Lee, JI; Lee, SH
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PLOS ONE 2021 10.1371/journal.pone.0251998 High-dose drug heat map analysis for drug safety and efficacy in multi-spheroid brain normal cells and GBM patient-derived cells Lee, SY; Teng, Y; Son, M; Ku, B; Moon, HS; Tergaonkar, V; Chow, PKH; Lee, DW; Nam, DH
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BIOMED PHARMACOTHER 2021 10.1016/j.biopha.2021.112278 Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses Nickel, AC; Picard, D; Qin, N; Wolter, M; Kaulich, K; Hewera, M; Pauck, D; Marquardt, V; Torga, G; Muhammad, S; Zhang, W; Schnell, O; Steiger, HJ; Hanggi, D; Fritsche, E; Her, NG; Nam, DH; Carro, MS; Remke, M; Reifenberger, G; Kahlert, UD
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MOLECULES 2021 10.3390/molecules26164949 Three-Dimensional Aggregated Spheroid Model of Hepatocellular Carcinoma Using a 96-Pillar/Well Plate Lee, SY; Teng, YN; Son, M; Ku, B; Hwang, HJ; Tergaonkar, V; Chow, PKH; Lee, DW; Nam, D
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WORLD NEUROSURG 2021 10.1016/j.wneu.2021.03.085 Safety and Efficacy of Endoscopic Dorsum Sellar Resection for Access to Retroinfundibular or Upper Clival Tumors (Korean Society of Endoscopic Neurosurgery-008) Kong¹, DS; Hong, SD; Kang, H; Seo, Y; Kim, MS; Seol, HJ; Park, CK; Nam, DH; Lee, JI; Kim, YH
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INT J MOL SCI 2021 10.3390/ijms22126240 Semi-Automated Cell Panning for Efficient Isolation of FGFR3-Targeting Antibody Min¹, B; Yoo, M; Kim, H; Cho, M; Nam, DH; Yoon, Y
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J NEURO-ONCOL 2021 10.1007/s11060-021-03774-y Early hormonal recovery following endoscopic transsphenoidal surgery for silent non-functioning pituitary adenomas with hormone dysfunction Lee¹, MH; Hur, KY; Hong, SD; Seol, HJ; Choi, JW; Lee, JI; Nam, D; Kong, DS
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EUR ARCH OTO-RHINO-L 2021 10.1007/s00405-021-06877-4 Learning curve and technical nuances of endoscopic skull base reconstruction with nasoseptal flap to control high-flow cerebrospinal fluid leakage: reconstruction after endoscopic skull base surgery other than pituitary surgery Park¹, W; Nam, D; Kong, DS; Lee, KE; Park, SI; Kim, HY; Chung, SK; Jung, YG; Hong, SD
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J KOREAN MED SCI 2021 10.3346/jkms.2021.36.e102 Optimal Volume of the Residual Tumor to Predict Long-term Tumor Control Using Stereotactic Radiosurgery after Facial Nerve-preserving Surgery for Vestibular Schwannomas Lee¹, WJ; Lee, JI; Choi, JW; Kong, DS; Nam, DH; Cho, YS; Shin, HJ; Seol, HJ
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CELL DEATH DIS 2021 10.1038/s41419-021-03657-0 Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma Choi¹, SW; Lee, Y; Shin, K; Koo, H; Kim, D; Sa, JK; Cho, HJ; Shin, HM; Lee, SJ; Kim, H; Chung, S; Shin, J; Lee, C; Nam, DH
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J KOREAN NEUROSURG SOC 2021 10.3340/jkns.2020.0135 Immune Checkpoint Inhibitors for Non-Small-Cell Lung Cancer with Brain Metastasis : The Role of Gamma Knife Radiosurgery Lee¹, MH; Cho, KR; Choi, JW; Kong, DS; Seol, HJ; Nam, DH; Jung, HA; Sun, JM; Lee, SH; Ahn, JS; Ahn, MJ; Park, K; Lee, JI
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ISCIENCE 2021 10.1016/j.isci.2021.102238 Azathioprine antagonizes aberrantly elevated lipid metabolism and induces apoptosis in glioblastoma Nam¹, HJ; Kim, YE; Moon, BS; Kim, HY; Jung, D; Choi, S; Jang, JW; Nam, DH; Cho, H
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CANCER LETT 2021 10.1016/j.canlet.2020.10.050 Clinical practice guidelines for the management of adult diffuse gliomas Jiang¹, T; Nam, DH; Ram, Z; Poon, WS; Wang, JG; Boldbaatar, D; Mao, Y; Ma, WB; Mao, Q; You, YP; Jiang, CL; Yang, XJ; Kang, CS; Qiu, XG; Li, WB; Li, SW; Chen, L; Li, XJ; Liu, ZX; Wang, WM; Bai, HM; Yao, Y; Li, SW; Wu, AH; Sai, K; Li, GL; Yao, K; Wei, XT; Liu, XZ; Zhang, ZW; Dai, YW; Lv, SQ; Wang, L; Lin, ZX; Dong, J; Xu, GZ; Ma, XD; Zhang, W; Zhang, CB; Chen, BS; You, G; Wang, YZ; Wang, YY; Bao, ZS; Yang, P; Fan, X; Liu, X; Zhao, Z; Wang, Z; Li, YM; Wang, ZL; Li, GZ; Fang, SY; Li, LW; Liu, YW; Liu, S; Shan, X; Liu, YQ; Chai, RC; Hu, HM; Chen, J; Yan, W; Cai, JQ; Wang, HJ; Chen, LC; Yang, Y; Wang, Y; Han, L; Wang, QX
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BRAIN 2021 10.1093/brain/awaa433 Modulation of Nogo receptor 1 expression orchestrates myelin-associated infiltration of glioblastoma Hong¹, JH; Kang, S; Sa, JK; Park, G; Oh, YT; Kim, TH; Yin, J; Kim, SS; D'Angelo, F; Koo, H; You, Y; Park, S; Kwon, HJ; Kim, CI; Ryu, H; Lin, W; Park, EJ; Kim, YJ; Park, MJ; Kim, H; Kim, MS; Chung, S; Park, CK; Park, SH; Kang, YH; Kim, JH; Saya, H; Nakano, I; Gwak, HS; Yoo, H; Lee, J; Hur, EM; Shi, BY; Nam, DH; Iavarone, A; Lee, SH; Park, JB
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CANCERS 2021 10.3390/cancers13030372 High-Content Analysis-Based Sensitivity Prediction and Novel Therapeutics Screening for c-Met-Addicted Glioblastoma Oh¹, JW; Oh, YJ; Han, S; Her, NG; Nam, DH
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STEREOT FUNCT NEUROS 2020 10.1159/000508737 Gamma Knife Radiosurgery as a Primary Treatment for Nonfunctioning Pituitary Adenoma Invading the Cavernous Sinus Lee¹, WJ; Cho, KR; Choi, JW; Kong, DS; Seol, HJ; Nam, DH; Lee, JI
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CANCERS 2020 10.3390/cancers12113210 Therapeutic Efficacy of GC1118, a Novel Anti-EGFR Antibody, against Glioblastoma with High EGFR Amplification in Patient-Derived Xenografts Lee¹, K; Koo, H; Kim, YJ; Kim, D; Son, E; Yang, H; Lim, Y; Hur, M; Lee, HW; Choi, SW; Nam, DH
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ACS OMEGA 2020 10.1021/acsomega.0c03102 cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody-Drug Conjugate Targeting c-Met Overexpression Tumors Min¹, B; Jin, J; Kim, H; Her, NG; Park, C; Kim, D; Yang, J; Hwang, J; Kim, E; Choi, M; Song, HY; Nam, DH; Yoon, Y
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J NEUROSURG 2020 10.3171/2019.5.JNS19222 Outcome evaluation of patients treated with fractionated Gamma Knife radiosurgery for large (> 3 cm) brain metastases a dose-escalation study Kim¹, KH; Kong, DS; Cho, KR; Lee, MH; Choi, JW; Seol, HJ; Kim, ST; Nam, DH; Lee, JI
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ACTA NEUROCHIR 2020 10.1007/s00701-020-04575-4 Stereotactic radiosurgery for orbital cavernous venous malformation a single center's experience for 15 years Lee¹, WJ; Cho, KR; Choi, JW; Kong, DS; Seol, HJ; Nam, D; Kim, YD; Woo, KI; Lee, JI
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CANCER MED 2020 10.1002/cam4.3370 Ethnic delineation of primary glioblastoma genome Koo¹, H; Choi, SW; Cho, HJ; Lee, IH; Kong, DS; Seol, HJ; Lee, JI; Choi, JW; Sa, JK; Nam, DH
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CANCER RES TREAT 2020 10.4143/crt.2019.421 Concurrent and Adjuvant Temozolomide for Newly Diagnosed Grade III Gliomas without 1p/19q Co-deletion: A Randomized, Open-Label, Phase 2 Study (KNOG-1101 Study) Hwang¹, K; Kim, TM; Park, CK; Chang, JH; Jung, TY; Kim, JH; Nam, DH; Kim, SH; Yoo, H; Hong, YK; Kim, EY; Lee, DE; Joo, J; Kim, YJ; Choe, G; Choi, BS; Kang, SG; Kim, JH; Kim, CY
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TARGET ONCOL 2020 10.1007/s11523-020-00706-0 Use of Gefitinib in EGFR-Amplified Refractory Solid Tumors: An Open-Label, Single-Arm, Single-Center Prospective Pilot Study Byeon¹, S; Hong, JY; Lee, J; Nam, DH; Park, SH; Park, JO; Park, YS; Lim, HY; Kang, WK; Kim, ST
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J CLIN MED 2020 10.3390/jcm9020533 Plasma Lysyl-tRNA Synthetase 1 (KARS1) as a Novel Diagnostic and Monitoring Biomarker for Colorectal Cancer Suh¹, JH; Park, MC; Goughnour, PC; Min, BS; Kim, SB; Lee, WY; Cho, YB; Cheon, JH; Lee, KY; Nam, DH; Kim, S
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J NEUROSURG 2019 10.3171/2018.6.JNS181099 Endoscopic transorbital surgery for Meckel's cave and middle cranial fossa tumors: surgical technique and early results Jeon¹, C; Hong, CK; Woo, KI; Hong, SD; Nam, DH; Lee, JI; Choi, JW; Seol, HJ; Kong, DS
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CANCERS 2019 10.3390/cancers11081090 Novel Semi-Replicative Retroviral Vector Mediated Double Suicide Gene Transfer Enhances Antitumor Effects in Patient-Derived Glioblastoma Models Lee¹, M; Kim, YS; Lee, K; Kang, M; Shin, H; Oh, JW; Koo, H; Kim, D; Kim, Y; Kong, DS; Nam, DH; Lee, HW
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J EXP MED 2019 10.1084/jem.20172170 PIP4K2A as a negative regulator of PI3K in PTEN-deficient glioblastoma Shin¹, YJ; Sa, JK; Lee, Y; Kim, D; Chang, N; Cho, HJ; Son, M; Oh, MYT; Shin, K; Lee, JK; Park, J; Jo, YK; Kim, M; Paddison, PJ; Tergaonkar, V; Lee, J; Nam, DH
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WORLD NEUROSURG 2019 10.1016/j.wneu.2019.01.157 Prediction of IDH1 Mutation Status in Glioblastoma Using Machine Learning Technique Based on Quantitative Radiomic Data Lee¹, MH; Kim, J; Kim, ST; Shin, HM; You, HJ; Choi, JW; Seol, HJ; Nam, DH; Lee, JI; Kong, DS
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J NEUROSURG 2019 10.3171/2017.12.JNS171943 Clinical and radiological outcomes of proactive Gamma Knife surgery for asymptomatic meningiomas compared with the natural course without intervention Kim¹, KH; Kang, SJ; Choi, JW; Kong, DS; Seol, HJ; Nam, DH; Lee, JI
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J NEUROSURG 2019 10.3171/2017.11.JNS171337 Selection of endoscopic or transcranial surgery for tuberculum sellae meningiomas according to specific anatomical features: a retrospective multicenter analysis (KOSEN-002) Kong¹, DS; Hong, CK; Hong, SD; Nam, DH; Lee, JI; Seol, HJ; Oh, J; Kim, DG; Kim, YH
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NAT GENET 2018 10.1038/s41588-018-0209-6 Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy Lee¹, JK; Liu, ZQ; Sa, JK; Shin, S; Wang, JG; Bordyuh, M; Cho, H; Elliott, O; Chu, T; Choi, SW; Rosenbloom, DIS; Lee, IH; Shin, YJ; Kang, HJ; Kim, D; Kim, SY; Sim, MH; Kim, J; Lee, T; Seo, YJ; Shin, H; Lee, M; Kim, SH; Kwon, YJ; Oh, JW; Song, M; Kim, M; Kong, DS; Choi, JW; Seol, HJ; Lee, JI; Kim, ST; Park, JO; Kim, KM; Song, SY; Lee, JW; Kim, HC; Lee, JE; Choi, MG; Seo, SW; Shim, YM; Zo, JI; Jeong, BC; Yoon, Y; Ryu, GH; Kim, NKD; Bae, JS; Park, WY; Lee, J; Verhaak, RGW; Iavarone, A; Lee, J; Rabadan, R; Nam, DH
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ASIA-PAC J CLIN ONCO 2018 10.1111/ajco.12861 Leptomeningeal enhancement on preoperative brain MRI in patients with glioblastoma and its clinical impact Kim¹, H; Lim, DH; Kim, TG; Lee, JI; Nam, DH; Seol, HJ; Kong, DS; Choi, JW; Suh, YL; Kim, ST
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INVEST NEW DRUG 2018 10.1007/s10637-017-0547-8 Drug repurposing screening identifies bortezomib and panobinostat as drugs targeting cancer associated fibroblasts (CAFs) by synergistic induction of apoptosis Lee¹, HM; Lee, E; Yeo, SY; Shin, S; Park, HK; Nam, DH; Kim, SH
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STEM CELL RES 2018 10.1016/j.scr.2018.07.006 Significant therapeutic effects of adult human multipotent neural cells on spinal cord injury Lee¹, KH; Pyeon, HJ; Nam, H; Won, JS; Hwang, JY; Lee, KA; Yeon, JY; Hong, SC; Nam, DH; Lee, K; Lee, SH; Joo, KM
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PLoS One 2018 10.1371/journal.pone.0202307 In vivo distribution of U87MG cells injected into the lateral ventricle of rats with spinal cord injury Won¹, JS; Nam, H; Lee, HW; Hwang, JY; Noh, YJ; Nam, DH; Lee, SH; Joo, KM
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CANCER RES TREAT 2018 10.4143/crt.2017.315 Anti-SEMA3A Antibody: A Novel Therapeutic Agent to Suppress Glioblastoma Tumor Growth Lee¹, J; Shin, YJ; Lee, K; Cho, HJ; Sa, JK; Lee, SY; Kim, SH; Lee, J; Yoon, Y; Nam, DH
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ANAL CHEM 2018 10.1021/acs.analchem.7b05328 3D Cell-Based High-Content Screening (HCS) Using a Micropillar and Microwell Chip Platform Lee¹, SY; Doh, I; Nam, DH; Lee, DW
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CELL DEATH DIS 2018 10.1038/s41419-018-0825-1 Potent effect of the MDM2 inhibitor AMG232 on suppression of glioblastoma stem cells Her¹, NG; Oh, JW; Oh, YJ; Han, S; Cho, HJ; Lee, Y; Ryu, GH; Nam, DH
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NEURO-ONCOLOGY 2018 10.1093/neuonc/noy020 Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium Aldape¹, K; Amin, SB; Ashley, DM; Barnholtz-Sloan, JS; Bates, AJ; Beroukhim, R; Bock, C; Brat, DJ; Claus, EB; Costello, JF; de Groot, JF; Finocchiaro, G; French, PJ; Gan, HK; Griffith, B; Herold-Mende, CC; Horbinski, C; Iavarone, A; Kalkanis, SN; Karabatsou, K; Kim, H; Kouwenhoven, MCM; McDonald, KL; Miletic, H; Nam, DH; Ng, HK; Niclou, SP; Noushmehr, H; Ormond, DR; Poisson, LM; Reifenberger, G; Roncaroli, F; Sa, JK; Smitt, PAES; Smits, M; Souza, CF; Tabatabai, G; Van Meir, EG; Verhaak, RGW; Watts, C; Wesseling, P; Woehrer, A; Yung, WKA; Jungk, C; Hau, AC; van Dyck, E; Westerman, BA; Yin, JL; Abiola, O; Zeps, N; Grimmond, S; Buckland, M; Khasraw, M; Sulman, EP; Muscat, AM; Stead, L
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CANCER CELL 2018 10.1016/j.ccell.2018.05.012 Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors Pavlyukov¹, MS; Yu, H; Bastola, S; Minata, M; Shender, VO; Lee, Y; Zhang, SJ; Wang, J; Komarova, S; Wang, J; Yamaguchi, S; Alsheikh, HA; Shi, JF; Chen, DQ; Mohyeldin, A; Kim, SH; Shin, YJ; Anufrieva, K; Evtushenko, EG; Antipova, NV; Arapidi, GP; Govorun, V; Pestov, NB; Shakhparonov, MI; Lee, LJ; Nam, DH; Nakano, I
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J Cancer 2018 10.7150/jca.26256 NCOA4-RET fusion in colorectal cancer: Therapeutic challenge using patient-derived tumor cell lines Kim¹, SY; Oh, SO; Kim, K; Lee, J; Kang, S; Kim, KM; Lee, W; Kim, ST; Nam, DN
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ONCOGENE 2018 10.1038/s41388-018-0182-7 Astrocyte-derived CCL20 reinforces HIF-1-mediated hypoxic responses in glioblastoma by stimulating the CCR6-NF-kappa B signaling pathway Jin¹, P; Shin, SH; Chun, YS; Shin, HW; Shin, YJ; Lee, Y; Kim, D; Nam, DH; Park, JW
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MED ONCOL 2018 10.1007/s12032-018-1119-2 Comparison of 1p and 19q status of glioblastoma by whole exome sequencing, array-comparative genomic hybridization, and fluorescence in situ hybridization Sim¹, J; Nam, DH; Kim, Y; Lee, IH; Choi, JW; Sa, JK; Suh, YL
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ANTICANCER RES 2018 10.21873/anticanres.12524 Pharmacokinetics, Biodistribution, and Toxicity Evaluation of Anti-SEMA3A (F11) in In Vivo Models Lee¹, J; Kim, D; Son, E; Yoo, SJ; Sa, JK; Shin, YJ; Yoon, Y; Nam, DH
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Cancer Med 2018 10.1002/cam4.1439 Identification of transcriptome signature for predicting clinical response to bevacizumab in recurrent glioblastoma Choi¹, SW; Shin, H; Sa, JK; Cho, HJ; Koo, H; Kong, DS; Seol, HJ; Nam, DH
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NAT GENET 2018 10.1038/s41588-018-0105-0 Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma deCarvalho¹, AC; Kim, H; Poisson, LM; Winn, ME; Mueller, C; Cherba, D; Koeman, J; Seth, S; Protopopov, A; Felicella, M; Zheng, SY; Multani, A; Jiang, YY; Zhang, JH; Nam, DH; Petricoin, EF; Chin, L; Mikkelsen, T; Verhaak, RGW
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J NEUROSURG 2018 10.3171/2016.12.JNS161920 Clinical outcomes of an endoscopic transclival and transpetrosal approach for primary skull base malignancies involving the clivus Kim¹, YH; Jeon, C; Se, YB; Hong, SD; Seol, HJ; Lee, JI; Park, CK; Kim, DG; Jung, HW; Han, DH; Nam, DH; Kong, DS
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TRANSL ONCOL 2018 10.1016/j.tranon.2017.10.002 Genetic and Clinical Characteristics of Phyllodes Tumors of the Breast Kim¹, JY; Yu, JH; Nam, SJ; Kim, SW; Lee, SK; Park, WY; Noh, DY; Nam, DH; Park, YH; Han, W; Lee, JE
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ONCOL LETT 2017 10.3892/ol.2017.7196 Preclinical and clinical implications of TERT promoter mutation in glioblastoma multiforme Jeong¹, DE; Woo, SR; Nam, H; Nam, DH; Lee, JH; Joo, KM
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BIOCHEM BIOPH RES CO 2017 10.1016/j.bbrc.2017.09.061 Antitumor activity, pharmacokinetics, tumor-homing effect, and hepatotoxicity of a species cross-reactive c-Met antibody Park¹, H; Kim, D; Son, E; Shin, S; Sa, JK; Kim, SH; Yoon, Y; Nam, DH
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MOL CELL BIOL 2017 10.1128/MCB.00265-17 RNF20 Suppresses Tumorigenesis by Inhibiting the SREBP1c-PTTG1 Axis in Kidney Cancer Lee¹, JH; Jeon, YG; Lee, KH; Lee, HW; Park, J; Jang, H; Kang, M; Lee, HS; Cho, HJ; Nam, DH; Kwak, C; Kim, JB
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J CLIN NEUROSCI 2017 10.1016/j.jocn.2017.07.012 Reconstructive outcome of intraoperative cerebrospinal fluid leak after endoscopic endonasal surgery for tumors involving skull base Jeon¹, CM; Hong, SD; Seol, HJ; Lee, JI; Nam, DH; Hwang, YJ; Kong, DS
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BIOMED RES INT 2017 10.1155/2017/7218707 High-Dose Compound Heat Map for 3D-Cultured Glioblastoma Multiforme Cells in a Micropillar and Microwell Chip Platform Lee¹, DW; Lee, SY; Doh, I; Ryu, GH; Nam, DH
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Clin Neuroradiol 2017 10.1007/s00062-016-0508-1 Differentiation of Hemangioblastoma from Metastatic Brain Tumor using Dynamic Contrast-enhanced MR Imaging Cha¹, J; Kim, ST; Nam, DH; Kong, DS; Kim, HJ; Kim, YK; Kim, HY; Park, GM; Jeon, P; Kim, KH; Byun, HS
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INT J MOL SCI 2017 10.3390/ijms18091968 Tumor Inhibitory Effect of IRCR201, a Novel Cross-Reactive c-Met Antibody Targeting the PSI Domain Park¹, H; Kim, D; Kim, E; Sa, JK; Lee, HW; Yu, S; Oh, J; Kim, SH; Yoon, Y; Nam, DH
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CANCER RES 2017 10.1158/0008-5472.CAN-17-0388 Transglutaminase 2 Inhibition Reverses Mesenchymal Transdifferentiation of Glioma Stem Cells by Regulating C/EBP beta Signaling Yin¹, J; Oh, YT; Kim, JY; Kim, SS; Choi, E; Kim, TH; Hong, JH; Chang, N; Cho, HJ; Sa, JK; Kim, JC; Kwon, HJ; Park, S; Lin, W; Nakano, I; Gwak, HS; Yoo, H; Lee, SH; Lee, J; Kim, JH; Kim, SY; Nam, DH; Park, MJ; Park, JB
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MOL CELL ENDOCRINOL 2017 10.1016/j.mce.2017.01.004 The role of STAT3 in glioblastoma progression through dual influences on tumor cells and the immune microenvironment Chang¹, N; Ahn, SH; Kong, DS; Lee, HW; Nam, DH
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NEURO-ONCOLOGY 2017 10.1093/neuonc/nox025 Is more better? The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma: a secondary analysis of EORTC and NRG Oncology/RTOG Blumenthal¹, DT; Gorlia, T; Gilbert, MR; Kim, MM; Nabors, LB; Mason, WP; Hegi, ME; Zhang, PX; Golfinopoulos, V; Perry, JR; Nam, DH; Erridge, SC; Corn, BW; Mirimanoff, RO; Brown, PD; Baumert, BG; Mehta, MP; van den Bent, MJ; Reardon, DA; Weller, M; Stupp, R
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ACTA NEUROCHIR 2017 10.1007/s00701-017-3230-0 Optimal treatment of jugular foramen schwannomas: long-term outcome of a multidisciplinary approach for a series of 29 cases in a single institute Ryu¹, SM; Lee, JI; Park, K; Choi, JW; Kong, DS; Nam, DH; Jeong, HS; Cho, YS; Seol, HJ
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WORLD NEUROSURG 2017 10.1016/j.wneu.2017.04.141 Outcome of Endoscopic Transsphenoidal Surgery for Acromegaly Kim¹, JH; Hur, KY; Lee, JH; Lee, JH; Se, YB; Kim, HI; Lee, SH; Nam, DH; Kim, SY; Kim, KW; Kong, DS; Kim, YH
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J CLIN INVEST 2017 10.1172/JCI89092 Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2 Wang¹, J; Cheng, P; Pavlyukov, MS; Yu, H; Zhang, Z; Kim, SH; Minata, M; Mohyeldin, A; Xie, WF; Chen, DQ; Goidts, V; Frett, B; Hu, WH; Li, HY; Shin, YJ; Lee, Y; Nam, DH; Kornblum, HI; Wang, MDD; Nakano, I
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J NEURO-ONCOL 2017 10.1007/s11060-017-2478-9 MGMT promoter methylation status as a prognostic factor for the outcome of gamma knife radiosurgery for recurrent glioblastoma Kim¹, BS; Kong, DS; Seol, HJ; Nam, DH; Lee, JI
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CANCER CELL 2017 10.1016/j.ccell.2017.06.003 Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment Wang¹, QH; Hu, BL; Hu, X; Kim, H; Squatrito, M; Scarpace, L; deCarvalho, AC; Lyu, S; Li, PP; Li, Y; Barthel, F; Cho, HJ; Lin, YH; Satani, N; Martinez-Ledesma, E; Zheng, SY; Chang, E; Sauve, CEG; Olar, A; Lan, ZD; Finocchiaro, G; Phillips, JJ; Berger, MS; Gabrusiewicz, KR; Wang, GC; Eskilsson, E; Hu, J; Mikkelsen, T; DePinho, RA; Muller, F; Heimberger, AB; Sulman, EP; Nam, DH; Verhaak, RGW
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Nat Genet. 2017 Apr;49(4):594-599. doi: 10.1038/ng.3806. Epub 2017 Mar 6. Spatiotemporal genomic architecture informs precision oncology in glioblastoma Lee JK1¹,2, Wang J3,4,5, Sa JK1,2,6, Ladewig E3,4, Lee HO7, Lee IH1,2, Kang HJ1,2, Rosenbloom DS3,4, Camara PG3,4, Liu Z3,4, van Nieuwenhuizen P3,4, Jung SW1,2,6, Choi SW1,2,6, Kim J1,2, Chen A3,4, Kim KT7, Shin S1,2,6, Seo YJ1,2, Oh JM1,2, Shin YJ1,2,7, Park CK8, Kong DS2, Seol HJ2, Blumberg A9, Lee JI2, Iavarone A10,11,12, Park WY6,7, Rabadan R3,4, Nam DH1,2,6.
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Org Biomol Chem. 2017 Feb 1;15(5):1198-1208. doi: 10.1039/c6ob02729f. Synthesis and anticancer activity of benzoselenophene and heteroaromatic derivatives of 1,2,9,9a-tetrahydrocyclopropa[c]benzo[e]indol-4-one (CBI) Mhetre AB1¹, Lee H1, Yang H2, Lee K2, Nam DH2, Lim D1.
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Oncotarget. 2017 Jan 24;8(4):7003-7013. doi: 10.18632/oncotarget.12273. Phase III randomized trial of autologous cytokine-induced killer cell immunotherapy for newly diagnosed glioblastoma in korea Kong DS1¹, Nam DH1, Kang SH2, Lee JW3, Chang JH4, Kim JH5, Lim YJ6, Koh YC7, Chung YG2, Kim JM8, Kim CH8.
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Oncotarget. 2017 Jan 31;8(5):8342-8355. doi: 10.18632/oncotarget.14184. MicroRNA-1908-5p contributes to the oncogenic function of the splicing factor SRSF3 Kim HR1¹, Shin CH1, Lee H1, Choi KH1, Nam DH1,2, Ohn T3, Kim HH1,4.
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Oncotarget. 2017 Jan 3;8(1):1321-1328. doi: 10.18632/oncotarget.13616. Genomic and transcriptomic characterization of skull base chordoma Sa JK1¹,2,3, Lee IH2,3, Hong SD4, Kong DS2,3,5, Nam DH1,2,3,5.
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J Korean Neurosurg Soc. 2017 Jan 1;60(1):21-29. doi: 10.3340/jkns.2016.0404.005. Epub 2016 Dec 29. The Influence of Biomarker Mutations and Systemic Treatment on Cerebral Metastases from NSCLC Treated with Radiosurgery Lee MH1¹, Kong DS1, Seol HJ1, Nam DH1, Lee JI1.
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World Neurosurg. 2016 Sep;93:164-7. doi: 10.1016/j.wneu.2016.06.006. Epub 2016 Jun 11. Nasoseptal Flap Elevation in Patients with History of Septal Surgery: Does It Increase Flap Failure or Cerebrospinal Fluid Leakage? Park W1¹, Hong SD2, Nam DH3, Kong DS3, Ryu G1, Kim HY1, Chung SK1, Dhong HJ1.
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Oncotarget. 2016 Aug 9;7(32):51626-51639. doi: 10.18632/oncotarget.10539. Establishment and antitumor effects of dasatinib and PKI-587 in BD-138T, a patient-derived muscle invasive bladder cancer preclinical platform with concomitant EGFR amplification and PTEN deletion Chang N1¹,2,3, Lee HW3,4, Lim JE5, Jeong DE1, Song HJ6, Kim S3,7, Nam DH1,2,3, Sung HH5, Jeong BC5, Seo SI5, Jeon SS5, Lee HM5, Choi HY5, Jeon HG5.
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PLoS One. 2016 Jul 8;11(7):e0158639. doi: 10.1371/journal.pone.0158639. eCollection 2016. Sensitive Tumorigenic Potential Evaluation of Adult Human Multipotent Neural Cells Immortalized by hTERT Gene Transduction Lee KH1¹,2, Nam H3,2, Jeong da E1,2, Kim SS1,2, Song HJ4,2, Pyeon HJ4,2, Kang K4, Hong SC1,2, Nam DH1,3,2, Joo KM1,4,2.
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World Neurosurg. 2016 May;89:215-22. doi: 10.1016/j.wneu.2016.01.038. Epub 2016 Jan 28. Functional Outcome of the Facial Nerve After Surgery for Vestibular Schwannoma: Prediction of Acceptable Long-Term Facial Nerve Function Based on Immediate Postoperative Facial Palsy Lee S1¹, Seol HJ2, Park K1, Lee JI1, Nam DH1, Kong DS1, Cho YS3.
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Oncotarget. 2016 May 17;7(20):29400-11. doi: 10.18632/oncotarget.8837. Anti-miR delivery strategies to bypass the blood-brain barrier in glioblastoma therapy Kim DG1¹,2, Kim KH2, Seo YJ2, Yang H2,3, Marcusson EG4, Son E2,5, Lee K1,2, Sa JK1,2, Lee HW1,2,6, Nam DH1,2,3.
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Headache. 2016 Apr 4. doi: 10.1111/head.12801. Gamma Knife Radiosurgery for Trigeminal Neuralgia Secondary to Benign Lesions Cho KR1¹, Lee MH1, Im YS1, Kong DS1, Seol HJ1, Nam DH1, Lee JI1.
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Genome Biol. 2016 Apr 29;17:80. doi: 10.1186/s13059-016-0945-9. Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma Kim KT1¹, Lee HW2, Lee HO1,3, Song HJ4, Jeong da E5, Shin S5, Kim H6, Shin Y6, Nam DH5,7, Jeong BC8, Kirsch DG9,10, Joo KM11,12, Park WY13,14,15.
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Lab Invest. 2016 Feb;96(2):137-50. doi: 10.1038/labinvest.2015.140. Epub 2015 Dec 7. WNT signaling in glioblastoma and therapeutic opportunities Lee Y1¹, Lee JK2, Ahn SH1, Lee J3, Nam DH1,4.
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없음 Mild generation of selenolate nucleophiles by thiol reduction of diselenides: convenient syntheses of selenyl-substituted aryl aldehydes
Biomaterials. 2011 Nov;32(33):8518-28. doi: 10.1016/j.biomaterials.2011.07.048. Epub 2011 Aug 30. Identification of a peptide that interacts with Nestin protein expressed in brain cancer stem cells Beck S1¹, Jin X, Yin J, Kim SH, Lee NK, Oh SY, Jin X, Kim MK, Kim EB, Son JS, Kim SC, Nam DH, Kim SH, Kang SK, Kim H, Choi YJ.
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Cancer Res. 2011 Nov 15;71(22):7125-34. doi: 10.1158/0008-5472.CAN-11-1330. Epub 2011 Oct 5. EGFR-AKT-Smad Signaling Promotes Formation of Glioma Stem-like Cells and Tumor Angiogenesis by ID3-Driven Cytokine Induction Jin X1¹, Yin J, Kim SH, Sohn YW, Beck S, Lim YC, Nam DH, Choi YJ, Kim H.
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Oncol Res. 2011;19(8-9):381-90. The Expression of DNA Damage Checkpoint Proteins and Prognostic Implication in Metastatic Brain Tumors Seol HJ1¹, Yoo HY, Jin J, Joo KM, Kim HS, Yoon SJ, Choi SH, Kim Y, Pyo HR, Lim DH, Kim W, Um HD, Kim JH, Lee JI, Nam DH.
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Oncol Rep. 2011 Aug;26(2):423-30. doi: 10.3892/or.2011.1325. Epub 2011 May 26. Prognostic implications of the DNA damage response pathway in glioblastoma Seol HJ1¹, Yoo HY, Jin J, Joo KM, Kong DS, Yoon SJ, Yang H, Kang W, Lim DH, Park K, Kim JH, Lee JI, Nam DH.
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Exp Mol Med. 2011 Jul 30;43(7):419-26. doi: 10.3858/emm.2011.43.7.046. Time-course analysis of DNA damage response-related genes after in vitro radiation in H460 and H1229 lung cancer cell lines Kim KH1¹, Yoo HY, Joo KM, Jung Y, Jin J, Kim Y, Yoon SJ, Choi SH, Seol HJ, Park WY, Nam do H.
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J Neurooncol. 2011 Jul;103(3):595-602. doi: 10.1007/s11060-010-0427-y. Epub 2010 Nov 4. Radiotherapy followed by adjuvant temozolomide with or without neoadjuvant ACNU-CDDP chemotherapy in newly diagnosed glioblastomas: a prospective randomized controlled multicenter phase III trial Kim IH1¹, Park CK, Heo DS, Kim CY, Rhee CH, Nam DH, Lee SH, Han JH, Lee SH, Kim TM, Kim DW, Kim JE, Paek SH, Kim DG, Kim IA, Kim YJ, Kim JH, Park BJ, Jung HW.
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Mol Ther. 2011 Jun;19(6):1161-9. doi: 10.1038/mt.2011.28. Epub 2011 Mar 8. hMSC-mediated Concurrent Delivery of Endostatin and Carboxylesterase to Mouse Xenografts Suppresses Glioma Initiation and Recurrence Yin J1¹, Kim JK, Moon JH, Beck S, Piao D, Jin X, Kim SH, Lim YC, Nam DH, You S, Kim H, Choi YJ.
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Cancer Res. 2011 Apr 15;71(8):3066-75. doi: 10.1158/0008-5472.CAN-10-1495. Epub 2011 Mar 1. Frizzled 4 Regulates Stemness and Invasiveness of Migrating Glioma Cells Established by Serial Intracranial Transplantation Jin X1¹, Jeon HY, Joo KM, Kim JK, Jin J, Kim SH, Kang BG, Beck S, Lee SJ, Kim JK, Park AK, Park WY, Choi YJ, Nam DH, Kim H.
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Preparation of blood-brain barrier-permeable paclitaxel-carrier conjugate and its chemotherapeutic activity in the mouse glioblastoma model
Biochem Biophys Res Commun. 2011 Mar 4;406(1):53-8. doi: 10.1016/j.bbrc.2011.01.106. Epub 2011 Feb 1. Inhibition of checkpoint kinase 1 sensitizes lung cancer brain metastases to radiotherapy Yang H1¹, Yoon SJ, Jin J, Choi SH, Seol HJ, Lee JI, Nam DH, Yoo HY.
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Mol Cells. 2010 Nov;30(5):403-8. doi: 10.1007/s10059-010-0122-z. Epub 2010 Aug 31. The Neural Stem Cell Fate Determinant TLX Promotes Tumorigenesis and Genesis of Cells Resembling Glioma Stem Cells (vol 30, pg 403, 2010) Park HJ1¹, Kim JK, Jeon HM, Oh SY, Kim SH, Nam DH, Kim H.
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AJNR Am J Neuroradiol. 2011 Feb;32(2):382-7. doi: 10.3174/ajnr.A2286. Epub 2011 Jan 20. Diagnostic Dilemma of Pseudoprogression in the Treatment of Newly Diagnosed Glioblastomas: The Role of Assessing Relative Cerebral Blood Flow Volume and Oxygen-6-Methylguanine-DNA Methyltransferase Promoter Methylation Status Kong DS1¹, Kim ST, Kim EH, Lim DH, Kim WS, Suh YL, Lee JI, Park K, Kim JH, Nam DH.
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Neurol Res. 2011 Jan;33(1):33-7. doi: 10.1179/016164110X12807570509899. Epub 2010 Aug 31. Functional neural stem cell isolation from brains of adult mutant SOD1 (SOD1(G93A)) transgenic amyotrophic lateral sclerosis (ALS) mice Lee JC1¹, Jin Y, Jin J, Kang BG, Nam DH, Joo KM, Cha CI.
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Oncol Rep. 2011 Jan;25(1):63-8. Combined treatment of tumor-tropic human neural stem cells containing the CD suicide gene effectively targets brain tumors provoking a mild immune response Lee SJ1¹, Kim Y, Jo MY, Kim HS, Jin Y, Kim SU, Jin J, Joo KM, Nam DH.
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Mol Cells. 2011 Jan;31(1):9-15. doi: 10.1007/s10059-011-0008-8. Epub 2010 Dec 24. Telomerase activity-independent function of TERT allows glioma cells to attain cancer stem cell characteristics by inducing EGFR expression Beck S1¹, Jin X, Sohn YW, Kim JK, Kim SH, Yin J, Pian X, Kim SC, Nam DH, Choi YJ, Kim H.
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Oncol Rep. 2011 Jan;25(1):33-9. Synergistic therapeutic effects of cytokine-induced killer cells and temozolomide against glioblastoma Jin J1¹, Joo KM, Lee SJ, Jo MY, Kim Y, Jin Y, Kim JK, Ahn JM, Yoon MJ, Lim J, Nam DH.
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Cancer Res. 2010 Dec 1;70(23):9730-41. doi: 10.1158/0008-5472.CAN-10-1882. Epub 2010 Nov 23. Negative Regulation of p53 by the Long Isoform of ErbB3 Binding Protein Ebp1 in Brain Tumors Kim CK1¹, Nguyen TL, Joo KM, Nam DH, Park J, Lee KH, Cho SW, Ahn JY.
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Cancer Res. 2010 Dec 15;70(24):10411-21. doi: 10.1158/0008-5472.CAN-10-2591. Epub 2010 Nov 5. CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche Kim M1¹, Koh YJ, Kim KE, Koh BI, Nam DH, Alitalo K, Kim I, Koh GY.
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Exp Ther Med. 2010 Nov;1(6):943-946. Epub 2010 Aug 26. Schedule-dependent synergistic effect of rituximab on methotrexate chemotherapy against lymphoma of the central nervous system Jin J1¹, Joo KM, Nam Y, Kim DH, Lee SJ, Jo MY, Jin Y, Kim HS, Seo SW, Kim SJ, Nam DH, Kim WS.
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Mol Cells. 2010 Nov;30(5):403-8. doi: 10.1007/s10059-010-0122-z. Epub 2010 Aug 31. The neural stem cell fate determinant TLX promotes tumorigenesis and genesis of cells resembling glioma stem cells Park HJ1¹, Kim JK, Jeon HM, Oh SY, Kim SH, Nam DH, Kim H.
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Treatment of atypical meningioma
Cancer Cell. 2010 Aug 9;18(2):171-84. doi: 10.1016/j.ccr.2010.07.001. Double Antiangiogenic Protein, DAAP, Targeting VEGF-A and Angiopoietins in Tumor Angiogenesis, Metastasis, and Vascular Leakage Koh YJ1¹, Kim HZ, Hwang SI, Lee JE, Oh N, Jung K, Kim M, Kim KE, Kim H, Lim NK, Jeon CJ, Lee GM, Jeon BH, Nam DH, Sung HK, Nagy A, Yoo OJ, Koh GY.
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BMC Cancer. 2010 Aug 13;10:424. doi: 10.1186/1471-2407-10-424. Impact of adjuvant chemotherapy for gliomatosis cerebri Kong DS1¹, Kim ST, Lee JI, Suh YL, Lim do H, Kim WS, Kwon KH, Park K, Kim JH, Nam DH.
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Neuro Oncol. 2010 Mar;12(3):289-96. doi: 10.1093/neuonc/nop030. Epub 2010 Jan 11. Phase II trial of low-dose continuous (metronomic) treatment of temozolomide for recurrent glioblastoma Kong DS1¹, Lee JI, Kim JH, Kim ST, Kim WS, Suh YL, Dong SM, Nam DH.
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Clin Neurol Neurosurg. 2009 Nov;111(9):748-51. doi: 10.1016/j.clineuro.2009.07.014. Epub 2009 Aug 28. Efficacy of temozolomide as adjuvant chemotherapy after postsurgical radiotherapy alone for glioblastomas Rhee DJ1¹, Kong DS, Kim WS, Park KB, Lee JI, Suh YL, Song SY, Kim ST, Lim DH, Park K, Kim JH, Nam DH.
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Clin Neurol Neurosurg. 2009 Oct;111(8):679-82. doi: 10.1016/j.clineuro.2009.06.013. Epub 2009 Jul 28. Clinical outcome of concomitant chemoradiotherapy followed by adjuvant temozolomide therapy for glioblastaomas: Single-center experience Jeon HJ1¹, Kong DS, Park KB, Lee JI, Park K, Kim JH, Kim ST, Lim do H, Kim WS, Nam DH.
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Cell Stem Cell. 2009 May 8;4(5):440-52. doi: 10.1016/j.stem.2009.03.003. SSEA-1 Is an Enrichment Marker for Tumor-Initiating Cells in Human Glioblastoma Son MJ1¹, Woolard K, Nam DH, Lee J, Fine HA.
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Mol Ther. 2009 Mar;17(3):570-5. doi: 10.1038/mt.2008.290. Epub 2009 Jan 6. Human Neural Stem Cells Can Target and Deliver Therapeutic Genes to Breast Cancer Brain Metastases Joo KM1¹, Park IH, Shin JY, Jin J, Kang BG, Kim MH, Lee SJ, Jo MY, Kim SU, Nam DH.
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Cancer. 2009 Jan 1;115(1):140-8. doi: 10.1002/cncr.23972. Prognostic Significance of c-Met Expression in Glioblastomas Kong DS1¹, Song SY, Kim DH, Joo KM, Yoo JS, Koh JS, Dong SM, Suh YL, Lee JI, Park K, Kim JH, Nam DH.
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Int J Oncol. 2008 Oct;33(4):705-12. Response of brain specific microenvironment to P-glycoprotein inhibitor: An important factor determining therapeutic effect of P-glycoprotein inhibitor on brain metastatic tumors Joo KM1¹, Song SY, Park K, Kim MH, Jin J, Kang BG, Jang MJ, Lee GS, Kim MS, Nam DH.
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Genes Dev. 2008 Aug 1;22(15):2028-33. doi: 10.1101/gad.1668708. Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling Jeon HM1¹, Jin X, Lee JS, Oh SY, Sohn YW, Park HJ, Joo KM, Park WY, Nam DH, DePinho RA, Chin L, Kim H.
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Lab Invest. 2008 Aug;88(8):808-15. doi: 10.1038/labinvest.2008.57. Epub 2008 Jun 16. Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas Joo KM1¹, Kim SY, Jin X, Song SY, Kong DS, Lee JI, Jeon JW, Kim MH, Kang BG, Jung Y, Jin J, Hong SC, Park WY, Lee DS, Kim H, Nam DH.
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Clin Cancer Res. 2008 Jul 1;14(13):4059-66. doi: 10.1158/1078-0432.CCR-07-4039. Activation of Notch signaling in a xenograft model of brain metastasis Nam DH1¹, Jeon HM, Kim S, Kim MH, Lee YJ, Lee MS, Kim H, Joo KM, Lee DS, Price JE, Bang SI, Park WY.
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J Clin Neurosci. 2008 Jun;15(6):721-2; author reply 722-3. doi: 10.1016/j.jocn.2007.08.031. Epub 2008 Apr 10. Reply to letter regarding Tc-99m-Tetrofosmin SPECT for the assessment of meningioma malignancy Alexiou GA¹, Tsiouris S, Goussia A, Polyzoidis KS, Fotopoulos AD, Kyritsis AP.
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Mol Med Rep. 2008 May-Jun;1(3):343-6. Antitumor activity of ZD6474 in a metastatic orthotopic brain tumor model Kong DS1¹, Kim MH, Jeon JW, Kim SY, Kim MS, Joo KM, Park K, Nam DH.
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Cancer. 2008 May 1;112(9):2046-51. doi: 10.1002/cncr.23402. Efficacy of stereotactic radiosurgery as a salvage treatment for recurrent malignant gliomas Kong DS1¹, Lee JI, Park K, Kim JH, Lim DH, Nam DH.
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Oncol Rep. 2008 Mar;19(3):639-43. The progression of gliomas is associated with cancer stem cell phenotype Kong DS1¹, Kim MH, Park WY, Suh YL, Lee JI, Park K, Kim JH, Nam DH.
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Oncol Rep. 2008 Jan;19(1):17-23. Oral paclitaxel chemotherapy for brain tumors: Ideal combination treatment of paclitaxel and P-glycoprotein inhibitor Joo KM1¹, Park K, Kong DS, Song SY, Kim MH, Lee GS, Kim MS, Nam DH.
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J Clin Neurosci. 2007 Aug;14(8):747-53. Epub 2007 May 17. Relationship between malignant subtypes of meningioma and clinical outcome Ko KW1¹, Nam DH, Kong DS, Lee JI, Park K, Kim JH.
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Headache. 2007 Feb;47(2):199-203. Atypical spontaneous intracranial hypotension (SIH) with nonorthostatic headache Kong DS1¹, Park K, Nam DH, Lee JI, Kim ES, Kim JS, Hong SC, Shin HJ, Eoh W, Kim JH.
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J Phys Chem B. 2012 Nov 8;116(44):13228-38. doi: 10.1021/jp3032918. Epub 2012 Oct 30. Development of a T-1 contrast agent for magnetic resonance imaging using MnO nanoparticles L?tourneau M1¹, Tremblay M, Faucher L, Rojas D, Chevallier P, Gossuin Y, Lagueux J, Fortin MA.
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J Neurosurg. 2006 Dec;105 Suppl:139-43. Preservation of quality of life by preradiotherapy stereotactic radiosurgery for unresectable glioblastoma multiforme Kong DS1¹, Nam DH, Lee JI, Park K, Kim JH.
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Oncol Rep. 2006 Nov;16(5):1117-21. A pilot study of metronomic temozolomide treatment in patients with recurrent temozolomide-refractory glioblastoma Kong DS1¹, Lee JI, Kim WS, Son MJ, Lim do H, Kim ST, Park K, Kim JH, Eoh W, Nam DH.
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Oncol Rep. 2006 Jul;16(1):33-9. Metronomic treatment of temozolomide inhibits tumor cell growth through reduction of angiogenesis and augmentation of apoptosis in orthotopic models of gliomas Kim JT1¹, Kim JS, Ko KW, Kong DS, Kang CM, Kim MH, Son MJ, Song HS, Shin HJ, Lee DS, Eoh W, Nam DH.
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Int J Oncol. 2006 Jun;28(6):1385-92. Synergistic effect and condition of pegylated interferon a with paclitaxel on glioblastoma Son MJ1¹, Song HS, Kim MH, Kim JT, Kang CM, Jeon JW, Park SY, Kim YJ, Groves MD, Park K, Kim JH, Nam DH.
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Oncol Rep. 2006 May;15(5):1163-8. Antiangiogenic agent, thalidomide increases the antitumor effect of single high dose irradiation (gamma knife radiosurgery) in the rat orthotopic glioma model Lee JI1¹, Itasaka S, Kim JT, Nam DH.
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Oncol Rep. 2006 Jan;15(1):7-13. Combination celecoxib and temozolomide in C6 rat glioma orthotopic model Kang SG1¹, Kim JS, Park K, Kim JS, Groves MD, Nam DH.
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Int J Oncol. 2006 Jan;28(1):53-9. Combination treatment with temozolomide and thalidomide inhibits tumor growth and angiogenesis in an orthotopic glioma model Son MJ1¹, Kim JS, Kim MH, Song HS, Kim JT, Kim H, Shin T, Jeon HJ, Lee DS, Park SY, Kim YJ, Kim JH, Nam DH.
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Neurol Med Chir (Tokyo). 2005 May;45(5):232-8; discussion 238-9. Clinical and radiological prognostic factors of anaplastic oligodendroglioma treated by combined therapy Kang SG1¹, Kim JH, Nam DH, Park K.
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Oncol Rep. 2004 Apr;11(4):863-9. Expression of VEGF and brain specific angiogenesis inhibitor-1 in glioblastoma: prognostic significance Nam DH1¹, Park K, Suh YL, Kim JH.
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Oncol Rep. 2004 Feb;11(2):263-8. Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib Nam DH1¹, Park K, Park C, Im YH, Kim MH, Lee S, Hong SC, Shin HJ, Kim JH, Eoh W, McDonnell TJ.
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Neurosci Lett. 2001 Oct 12;312(1):41-4. Expression of interleukin-1 beta in lipopolysaccharide stimulated monocytes derived from patients with aneurysmal subarachnoid hemorrhage is correlated with cerebral vasospasm Nam DH1¹, Kim JS, Hong SC, Lee WH, Lee JI, Shin HJ, Park K, Eoh W, Han DH, Kim JH.
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Exp Mol Med. 2001 Sep 30;33(3):111-6. Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas Nam DH1¹, Song SY, Park K, Kim MH, Suh YL, Lee JI, Kim JS, Hong SC, Shin HJ, Park K, Eoh W, Kim JH.
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Int J Oncol. 2001 Jan;18(1):111-6. The detection of p53 gene mutation using a microdissection technique in primary intracranial germ cell tumors Kim SK1¹, Cho BK, Paek SH, Hong SJ, Kim HS, Hong SY, Choe G, Chi JG, Nam DH, Wang KC.
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J Korean Med Sci. 2000 Aug;15(4):452-6. The effect of isochromosome 17q presence, proliferative and apoptotic indices, expression of c-erbB-2, bcl-2 and p53 proteins on the prognosis of medulloblastoma Nam DH1¹, Wang KC, Kim YM, Chi JG, Kim SK, Cho BK.
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Neurosci Lett. 2000 Mar 31;283(1):45-8. Vascular endothelial growth factor expression under ischemic stress in human meningiomas Park K1¹, Kim JH, Nam DH, Lee JI, Kim JS, Hong SC, Shin HJ, Eoh W, Park K.
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Childs Nerv Syst. 1999 Apr;15(4):185-91. Treatment of intracranial nongerminomatous malignant germ cell tumor in children: the role of each treatment modality Nam DH1¹, Cho BK, Shin HJ, Ahn HS, Kim IH, Wang KC.
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Childs Nerv Syst. 1999 Apr;15(4):179-84. A simple method of predicting hormonal outcome in children with intracranial germinoma Nam DH1¹, Wang KC, Shin CH, Yang SW, Cho BK.
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2019.12.26
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2019.05.30
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2017.08.10
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2017.03.11
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2017.03.08
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2016.06.07
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2016.03.30
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2016.01.06
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2015.12.16
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2015.09.17
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2015.09.16
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2013.01.29
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뇌종양 치료 '아바타 쥐'로 대신...'맞춤형 치료' 기대

2013.01.29
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환자와 꼭 닮은 '아바타 마우스', 악성뇌종양 치료한다

2013.01.29
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뇌종양 치료...'아바타마우스'가 대신한다!

2013.01.29
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암줄기세포 연구로 환자들에게 새로운 세상을 열어주다, 신경외과 남도현 교수

2012.11.29
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삼성서울병원, 바이오신약 개발한다

2010.01.28
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[건강]두통·경련·구토땐 뇌종양 의심…종양 종류따라 수술·항암치료

2009.05.14
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유전정보 이용한 맞춤치료

2008.11.08
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간단해진 뇌수술 겁먹을 필요 없다

2008.06.18
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악성뇌종양 최신 치료법

2004.09.20
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불청객 뇌종양 젊은이도 조심

2006.07.19
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뇌종양 환자 10명중 4명이 30.40대

2005.11.25
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30~40대 뇌종양 조심

2005.11.23
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뇌종양 40%이상 30~40대

2005.11.21
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뇌종양 환자 30~40대 가장 많아

2005.11.21
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아침 두통, 뇌종양 검사부터 받아보세요

2005.12.08

외래 항암화학요법중인 유방암 환자의 수면의 질

논문
게재일	2014-10-22
발표년월	2012-05	구분	국내
학술지	가정의학회지
논문명(국문)
논문명(영문)
요약문	td	발행정보	2010;31(10):778-785
책임저자	이정권
저자	박주현, 이선진, 곽정임, 심재용, 이정권	제 1저자	박주현
초록첨부	test
논문첨부

신경외과 남도현 교수

학력

경력

연구분야

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아바타메드, CBmed와 암 정밀 의료 프로젝트 연구 및 사업 협약 체결

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'교모세포종' 예후 예측하는 바이오마커 발견...치료법 제시

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부인암도 맞춤치료 시대 열리나

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종양 주변 면역세포 억제해 항암치료

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“악성 뇌종양, 주변의 면역세포가 항암치료 방해”

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국내 연구진, 악성 뇌종양 치료하는 정밀의료 문 열어

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악성 뇌종양 새 치료길 열렸다…4~5년내 상용화

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9대 국가전략 프로젝트 2조 원 투입, 미래 한국 먹여 살린다

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국내 연구진, 악성뇌종양 표적유전자 세계 첫 규명...치료 길 열어

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기조발표하는 남도현 사업단장

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융기원, 3차원 세포배양기술 이용한 새로운 암치료법 개발

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서울대의대 함춘동아의학賞 남도현

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말기 뇌종양 60대 환자에 첫 맞춤형 ‘아바타 치료’

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뇌종양, 재발 위치 따라 ‘치료법’도 바뀐다

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재발 잦은 뇌종양, 표적치료 가능성 찾았다

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[미래의학을 향한 삼성서울병원의 도전] (2) 5년내 암환자 유전체 분석.. 개인별 항암치료시대 열린다

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서지도 못하던 아이 걷게하는 '유전자 치료'… 한국은 검사부터 規制

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암치료에 새 지평...의료수출 핵심기술

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너는 오늘 하루를 제대로 다 불태웠니

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채널A 종합뉴스 [KRS 단백질 작동 막아…폐암·유방암 100% 차단물질 찾았다]

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난치성 교모세포종 억제 새 신호전달 경로 첫 규명

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발암 유전자로 '뇌종양 억제'

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삼성서울병원, 새로운 뇌종양 억제법 규명

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뇌종양 발생 억제 새 신호전달 경로 규명

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국내 연구진, 뇌종양 형성 새 매커니즘 세계 첫 규명

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삼성병원 연구진, "뇌종양 막는 새 경로 발견"

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뇌종양 형성 새 메커니즘 세계 첫 규명

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뇌종양 억제 매커니즘 규명

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뇌종양 형성 새 메커니즘 세계 첫 규명

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뇌종양 억제 새 신호전달 경로 규명

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뇌종양 억제 새 메커니즘 발견

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삼성서울병원, 암 맞춤치료 솔루션 개발 나서