바로가기 메뉴

단축키 목록

맨 위로

현재 페이지 위치 : Center for Clinical Epidemiology > RESEARCH > Research Outcome

Research Outcome

글 내용
제목 Influence of gender on age-associated in-hospital mortality in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study
작성자 관리자 등록일 2023-06-30

내용

Influence of gender on age-associated in-hospital mortality in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study

Ryoung-Eun Ko # 1Danbee Kang # 2 3Juhee Cho 2 3Soo Jin Na 1Chi Ryang Chung 1Sung Yoon Lim 4Yeon Joo Lee 4Sunghoon Park 5Dong Kyu Oh 6Su Yeon Lee 6Mi Hyeon Park 6Haein Lee 6Chae-Man Lim 6Gee Young Suh 7 8Korean Sepsis Alliance (KSA) investigators

Collaborators, Affiliations 

Free PMC article

Abstract

Background: Numerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have shown conflicting evidence. This study aimed to investigate the effect of gender on in-hospital mortality due to sepsis according to age group.

Methods: This study used data from the Korean Sepsis Alliance, an ongoing nationwide prospective multicenter cohort from 19 participating hospitals in South Korea. All adult patients diagnosed with sepsis in the emergency departments of the participating hospitals between September 2019 and December 2021 were included in the analysis. Clinical characteristics and outcomes were compared between male and female. Eligible patients were stratified by age into 19-50 years, 50-80 years, and ≥ 80 years old individuals.

Results: During the study period, 6442 patients were included in the analysis, and 3650 (56.7%) were male. The adjusted odds ratio (OR) [95% confidence interval (CI)] for in-hospital mortality for male compared with female was 1.15 (95% CI = 1.02-1.29). Interestingly, in the age 19-50 group, the risk of in-hospital mortality for males was significantly lower than that of females [0.57 (95% CI = 0.35-0.93)]. For female, the risk of death remained relatively stable until around age 80 (P for linearity = 0.77), while in males, there was a linear increase in the risk of in-hospital death until around age 80 (P for linearity < 0.01). Respiratory infection (53.8% vs. 37.4%, p < 0.01) was more common in male, whereas urinary tract infection (14.7% vs. 29.8%, p < 0.01) was more common in female. For respiratory infection, male had significantly lower in-hospital mortality than female in the age 19-50 groups (adjusted OR = 0.29, 95% CI = 0.12-0.69).

Conclusions: Gender may influence age-associated sepsis outcomes. Further studies are needed to replicate our findings and fully understand the interaction of gender and age on the outcomes of patients with sepsis.

Keywords: Age; Gender; Sepsis; Septic shock; Sex.

목록