Nuclear Medicine
Lee, Kyung Han
95 AppointmentProfessor
Sungkyunkwan University School of Medicine
Chairman, Department of Nuclear Medicine
Samsung Medical Center
Speciality Interests
Nuclear Neurology
Schedule
02 | TUE 11 |
WEN 12 |
THU 13 |
FRI 14 |
MON 17 |
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AM | |||||
PM |
Medical School
Seoul National University College of Medicine
Specialty Training
Fellowship | Seoul National University Hospital | |
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Residency | Seoul National University Hospital | |
Internship | Seoul National University Hospital |
Participation in Academic Societies
and Research
Member, Korean Medical Association
Member, Korean Association of Internal Medicine
Member and Scientific Committee, Korean Society of Nuclear Medicine
Member, Korean Society of Biochemistry and Molecular Biology
Member, Society of Nuclear Medicine
Member, European Association of Nuclear Medicine
Board of Trustee, Korean Society of Nuclear Medicine
Board of Trustee, Korean Society of Molecular Imaging
Editorial Board, Open Journal of Medical Imaging
Editorial Board, Open Journal of Nuclear Medicine
Editorial Board, Journal of Korean Medical Science
Editorial Board, Nuclear Medicine and Molecular Imaging
Thesis
SCI REP-UK 2021 10.1038/s41598-021-88815-2
Role in staging and prognostic value of pretherapeutic F-18 FDG PET/CT in patients with gastric MALT lymphoma without high-grade transformation
SCI REP-UK 2021 10.1038/s41598-021-85332-0
Metabolic activity of extranodal NK/T cell lymphoma on F-18-FDG PET/CT according to immune subtyping
SCI REP-UK 2021 10.1038/s41598-021-83496-3
Zr-89 anti-CD44 immuno-PET monitors CD44 expression on splenic myeloid cells and HT29 colon cancer cells
CANCERS 2021 10.3390/cancers13040712
Prognostic Significance of Metabolic Parameters by F-18-FDG PET/CT in Thymic Epithelial Tumors
ONCOL LETT 2020 10.3892/ol.2020.12237
Genipin enhances the antitumor effect of elesclomol in A549 lung cancer cells by blocking uncoupling protein-2 and stimulating reactive oxygen species production
BLOOD ADV 2020 10.1182/bloodadvances.2020002814
A risk model for relapsed/refractory aggressive NHL integrating clinical risk factors and pretransplant Deauville score
EUR RADIOL 2020 10.1007/s00330-020-07523-z
Machine learning-based diagnostic method of pre-therapeutic F-18-FDG PET/CT for evaluating mediastinal lymph nodes in non-small cell lung cancer
J NUCL CARDIOL 2020 10.1007/s12350-018-1424-3
Serum uric acid in asymptomatic adults is weakly associated with carotid artery FDG uptake but not intima-media thickness
SCI REP-UK 2020 10.1038/s41598-020-70168-x
Metabolic radiogenomics in lung cancer associations between FDG PET image features and oncogenic signaling pathway alterations
SCI REP-UK 2020 10.1038/s41598-020-71366-3
Targeting poor proteasomal function with radioiodine eliminates CT26 colon cancer stem cells resistant to bortezomib therapy
SCI REP-UK 2020 10.1038/s41598-020-69550-6
Comparison of the prognostic values of F-18-fluorodeoxyglucose parameters from colon and non-colon sites of involvement in diffuse large B-cell lymphoma of the colon
CLIN NUCL MED 2020 10.1097/RLU.0000000000002926
Tumor SUVs on F-18-FDG PET/CT and Aggressive Pathological Features in Esophageal Squamous Cell Carcinoma
PLoS One 2020 10.1371/journal.pone.0228848
Tc-99m-MIBI uptake as a marker of mitochondrial membrane potential in cancer cells and effects of MDR1 and verapamil
ONCOL REP 2020 10.3892/or.2019.7436
Troglitazone exerts metabolic and antitumor effects on T47D breast cancer cells by suppressing mitochondrial pyruvate availability
EUR J NUCL MED MOL I 2020 10.1007/s00259-020-04698-x
Imaging phenotype using F-18-fluorodeoxyglucose positron emission tomography-based radiomics and genetic alterations of pancreatic ductal adenocarcinoma
BIOORGAN MED CHEM 2020 10.1016/j.bmc.2019.115212
Synthesis and characterization of Cu-64- and Cy5.5-labeled tetraiodothyroacetic acid derivatives for tumor angiogenesis imaging
EUR RADIOL 2019 10.1007/s00330-019-06128-5
Comparison of prognostic values of primary tumor and nodal F-18-fluorodeoxyglucose uptake in non-small cell lung cancer with N1 disease
SCI REP-UK 2019 10.1038/s41598-019-48674-4
Predictive and Prognostic Value of F-18-fluorodeoxyglucose Uptake Combined with Thymidylate Synthase Expression in Patients with Advanced Non-Small Cell Lung Cancer
EUR J NUCL MED MOL I 2019 10.1007/s00259-019-04327-2
Prognostic value of F-18-fluorodeoxyglucose positron emission tomography/computed tomography in patients with combined hepatocellular-cholangiocarcinoma
SCI REP-UK 2019 10.1038/s41598-019-43257-9
Synthesis and in vivo characterization of F-18-labeled difluoroboron-curcumin derivative for beta-amyloid plaque imaging
SCI REP-UK 2019 10.1038/s41598-019-43215-5
Maximum standardized uptake value on F-18-fluorodeoxyglucose positron emission tomography/computed tomography improves outcome prediction in retroperitoneal liposarcoma
EUR RADIOL 2019 10.1007/s00330-018-5764-9
PET/CT features discriminate risk of metastasis among single-bone FDG lesions detected in newly diagnosed non-small-cell lung cancer patients
SCI REP-UK 2019 10.1038/s41598-019-42954-9
ATP-binding Cassette Transporters Substantially Reduce Estimates of ALDH-positive Cancer Cells based on Aldefluor and AldeRed588 Assays
ACS CHEM NEUROSCI 2019 10.1021/acschemneuro.8b00480
F-18-Labeled BODIPY Dye: A Potential Prosthetic Group for Brain Hybrid PET/Optical Imaging Agents
CLIN RADIOL 2019 10.1016/j.crad.2018.12.010
Evaluation of a diagnostic F-18-FDG PET/CT strategy for differentiating benign from malignant retroperitoneal soft-tissue masses
EUR J NUCL MED MOL I 2019 10.1007/s00259-018-4138-5
Correlations between metabolic texture features, genetic heterogeneity, and mutation burden in patients with lung cancer
J NEUROL SCI 2019 10.1016/j.jns.2018.10.025
Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease
SCI REP-UK 2018 10.1038/s41598-018-29642-w
Reporter PET Images Bortezomib Treatment-Mediated Suppression of Cancer Cell Proteasome Activity
ONCOL LETT 2018 10.3892/ol.2018.8471
Targeted therapy of triple negative MDA-MB-468 breast cancer with curcumin delivered by epidermal growth factor-conjugated phospholipid nanoparticles
PLoS One 2018 10.1371/journal.pone.0196808
Role of F-18-FDG PET/CT in patients without known primary malignancy with skeletal lesions suspicious for cancer metastasis
EUR J NEUROL 2018 10.1111/ene.13500
Longitudinal cortical thinning and cognitive decline in patients with early- versus late-stage subcortical vascular mild cognitive impairment
J NEUROL 2018 10.1007/s00415-017-8650-5
Prognostic value of amyloid PET scan in normal pressure hydrocephalus
MOL IMAGING 2017 10.1177/1536012117737399
Radiolabeled Anti-Adenosine Triphosphate Synthase Monoclonal Antibody as a Theragnostic Agent Targeting Angiogenesis
ONCOTARGET 2017 10.18632/oncotarget.19544
Inhibition of aldehyde dehydrogenase 1 enhances the cytotoxic effect of retinaldehyde on A549 cancer cells
SCI REP-UK 2017 10.1038/s41598-017-16236-1
Centiloid method evaluation for amyloid PET of subcortical vascular dementia
EUR J NUCL MED MOL I 2017 10.1007/s00259-017-3705-5
Strong association of epidermal growth factor receptor status with breast cancer FDG uptake
SCI REP-UK 2017 10.1038/s41598-017-10074-x
Correlations between Gray Matter and White Matter Degeneration in Pure Alzheimer's Disease, Pure Subcortical Vascular Dementia, and Mixed Dementia
Leuk Lymphoma. 2017 Jun;58(6):1341-1348. doi: 10.1080/10428194.2016.1236380. Epub 2016 Oct 9.
Value of interim FDG PET/CT for predicting outcome of patients with angioimmunoblastic T-cell lymphoma
Sci Rep. 2017 May 15;7(1):1910. doi: 10.1038/s41598-017-02046-y.
Protective effects of APOE e2 against disease progression in subcortical vascular mild cognitive impairment patients: A three-year longitudinal study
Medicine (Baltimore). 2017 Feb;96(5):e5935. doi: 10.1097/MD.0000000000005935.
Relation between tumor FDG uptake and hematologic prognostic indicators in stage I lung cancer patients following curative resection
NUCLEAR MEDICINE AND BIOLOGY, FEB 2017, 45:8-14, DOI: 10.1016/j.nucmedbio.2016.10.006
Reactive oxygen species-driven HIFI alpha triggers accelerated glycolysis in endothelial cells exposed to low oxygen tension
J Nucl Med. 2016 Apr;57(4):544-50. doi: 10.2967/jnumed.115.163295. Epub 2015 Dec 17.
Primary Tumor F-18-FDG Avidity Affects the Performance of F-18-FDG PET/CT for Detecting Gastric Cancer Recurrence
Neurology. 2016 Mar 29;86(13):1199-207. doi: 10.1212/WNL.0000000000002516. Epub 2016 Mar 2.
Gray and white matter changes linking cerebral small vessel disease to gait disturbances
Clin Nucl Med. 2016 Feb;41(2):e82-6. doi: 10.1097/RLU.0000000000000992.
Clinical Significance of Incidental F-18-FDG Uptake in the Pyriform Sinus Detected by PET/CT
J Alzheimers Dis. 2016;50(3):709-18. doi: 10.3233/JAD-150637.
Distinctive Resting State Network Disruptions Among Alzheimer's Disease, Subcortical Vascular Dementia, and Mixed Dementia Patients
Neurology. 2016 Feb 9;86(6):527-34. doi: 10.1212/WNL.0000000000002357. Epub 2016 Jan 13.
Early- vs late-onset subcortical vascular cognitive impairment
Oncol Rep. 2016 Feb;35(2):861-8. doi: 10.3892/or.2015.4460. Epub 2015 Nov 26.
Effects of curcumin on cancer cell mitochondrial function and potential monitoring with F-18-FDG uptake
BRITISH JOURNAL OF RADIOLOGY, 2016, 89(1067), DOI: 10.1259/bjr.20160109
Value of F-18-FDG heterogeneity for discerning metastatic from benign lymph nodes in nasopharyngeal carcinoma patients with suspected recurrence
ANNALS OF NUCLEAR MEDICINE, NOV 2016, 30(9):619-623, DOI: 10.1007/s12149-016-1103-x
Incidental focal F-18-FDG uptake in the frontal process of the maxilla on PET/CT: prevalence and clinical significance
Mol Imaging Biol. 2016 Oct;18(5):748-57. doi: 10.1007/s11307-016-0941-1.
Imaging Early Fate of Cancer Stem Cells in Mouse Hindlimbs with Sodium Iodide Symporter Gene and I-124 PET
PLoS One. 2016 Oct 31;11(10):e0165814. doi: 10.1371/journal.pone.0165814. eCollection 2016.
Body Mass Index with Tumor F-18-FDG Uptake Improves Risk Stratification in Patients with Breast Cancer
NUCLEAR MEDICINE AND BIOLOGY, OCT 2016, 43(10):587-592, DOI: 10.1016/j.nucmedbio.2016.06.001
Molecular mechanism of F-18-FDG uptake reduction induced by genipin in T47D cancer cell and role of uncoupling protein-2 in cancer cell glucose metabolism
Lung Cancer. 2016 Oct;100:24-29. doi: 10.1016/j.lungcan.2016.07.025. Epub 2016 Jul 26.
Value of volume-based early metabolic response in patients with unresectable thymic epithelial tumor
J Alzheimers Dis. 2016 Oct 4;54(3):1015-1026.
The Role of Cerebrovascular Disease in Amyloid Deposition
Neurology. 2016 Oct 11;87(15):1575-1582. Epub 2016 Sep 14.
Synergistic effects of longitudinal amyloid and vascular changes on lobar microbleeds
JOURNAL OF NUCLEAR MEDICINE, JAN 2016 , 57(1):129-135, DOI: 10.2967/jnumed.115.162016
Troglitazone Stimulates Cancer Cell Uptake of F-18-FDG by Suppressing Mitochondrial Respiration and Augments Sensitivity to Glucose Restriction
Brain. 2016 Sep;139(Pt 9):2516-27. doi: 10.1093/brain/aww148. Epub 2016 Jun 21.
Relative impact of amyloid-beta, lacunes, and downstream imaging markers on cognitive trajectories
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, AUG 2016, 43(9):1638-1645, DOI: 10.1007/s00259-016-3348-y
Prognostic value of F-18-fluorodeoxyglucose positron emission tomography/computed tomography in patients with Barcelona Clinic Liver Cancer stages 0 and A hepatocellular carcinomas: a multicenter retrospective cohort study
PLoS One. 2016 Aug 1;11(8):e0159529. doi: 10.1371/journal.pone.0159529. eCollection 2016.
Mild Alkalization Acutely Triggers the Warburg Effect by Enhancing Hexokinase Activity via Voltage-Dependent Anion Channel Binding
Medicine (Baltimore). 2016 Aug;95(32):e4266. doi: 10.1097/MD.0000000000004266.
Relation between primary tumor FDG avidity and site of first distant metastasis in patients with breast cancer
Nuklearmedizin. 2016 Aug 5;55(4):166-71. doi: 10.3413/Nukmed-0768-15-09. Epub 2015 Dec 3.
Incidental Tc-99m MDP uptake in the intestines and intravenous CT contrast
JOURNAL OF NUCLEAR MEDICINE, JUL 2016, 57(7):1058-1064, DOI: 10.2967/jnumed.115.169177
Prediction of PSA Progression in Castration-Resistant Prostate Cancer Based on Treatment-Associated Change in Tumor Burden Quantified by F-18-Fluorocholine PET/CT
Amino Acids. 2016 Jul;48(7):1667-75. doi: 10.1007/s00726-016-2227-y. Epub 2016 Apr 20.
Catabolism of Cu-64 and Cy5.5-labeled human serum albumin in a tumor xenograft model
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, JUL 2016, 43(8):1461-1468, DOI: 10.1007/s00259-016-3316-6
Intratumoral heterogeneity of F-18-FDG uptake predicts survival in patients with pancreatic ductal adenocarcinoma
Clin Nucl Med. 2016 May;41(5):e237-43. doi: 10.1097/RLU.0000000000001153.
Utility of FDG PET/CT for Differential Diagnosis of Patients Clinically Suspected of IgG4-Related Disease
Sci Rep. 2015 Sep 22;5:14205. doi: 10.1038/srep14205.
Introduction of Methyl Groups at C2 and C6 Positions Enhances the Antiangiogenesis Activity of Curcumin
J Neurol Sci. 2015 Dec 15;359(1-2):381-8. doi: 10.1016/j.jns.2015.11.018. Epub 2015 Nov 10.
Long term outcome and predictors of ischemic stroke recurrence in adult moyamoya disease
PLoS One. 2015 Dec 18;10(12):e0145020. doi: 10.1371/journal.pone.0145020. eCollection 2015.
Influence of Body Mass Index on the Prognostic Value of Tumor F-18-FDG Uptake in Stage I Non-Small Cell Lung Cancer
J Nucl Med. 2015 Dec;56(12):1855-61. doi: 10.2967/jnumed.115.158253. Epub 2015 Sep 17.
Multicenter Reproducibility of F-18-Fluciclatide PET Imaging in Subjects with Solid Tumors
Neurology. 2015 Nov 10;85(19):1687-93. doi: 10.1212/WNL.0000000000002097. Epub 2015 Oct 14.
Effects of amyloid and vascular markers on cognitive decline in subcortical vascular dementia
RSC ADVANCES, 2015, 5(117):96733-96745, DOI:10.1039/c5ra15380h
Synthesis and characterization of F-18-labeled hydrazinocurcumin derivatives for tumor imaging
EJNMMI RESEARCH, OCT 31 2015, 5, UNSP 60, 10.1186/s13550-015-0140-0
Hybrid PET/optical imaging of integrin alpha(V)beta(3) receptor expression using a Cu-64-labeled streptavidin/biotin-based dimeric RGD peptide
Neurobiol Aging. 2015 Jan;36(1):485-91. doi: 10.1016/j.neurobiolaging.2014.08.009. Epub 2014 Sep 28.
Hippocampal volume and shape in pure subcortical vascular dementia
JACC Cardiovasc Imaging. 2015 Aug;8(8):949-56. doi: 10.1016/j.jcmg.2015.06.002. Epub 2015 Jul 15.
Carotid FDG Uptake Improves Prediction of Future Cardiovascular Events in Asymptomatic Individuals
Neurology. 2015 Jul 7;85(1):63-70. doi: 10.1212/WNL.0000000000001705. Epub 2015 Jun 10.
Clinical effect of white matter network disruption related to amyloid and small vessel disease
Alzheimers Dement. 2015 May;11(5):494-503.e3. doi: 10.1016/j.jalz.2014.04.521. Epub 2014 Jul 19.
Amyloid burden, cerebrovascular disease, brain atrophy, and cognition in cognitively impaired patients
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Association Between Nonalcoholic Fatty Liver Disease and Carotid Artery Inflammation Evaluated by F-18-Fluorodeoxyglucose Positron Emission Tomography
Eur J Neurol. 2015 Apr;22(4):709-16. doi: 10.1111/ene.12645. Epub 2015 Jan 21.
White matter microstructural changes in pure Alzheimer's disease and subcortical vascular dementia
Clin Nucl Med. 2015 Mar;40(3):260-2. doi: 10.1097/RLU.0000000000000623.
Multifocal Hot Spots Demonstrated by Whole-Body I-131 Scintigraphy and SPECT/CT After Transaxillary Endoscopic Thyroidectonny
J Alzheimers Dis. 2015;44(4):1075-85. doi: 10.3233/JAD-141773.
Apolipoprotein E4 Affects Topographical Changes in Hippocampal and Cortical Atrophy in Alzheimer's Disease Dementia: A Five-Year Longitudinal Study
Clin Nucl Med. 2015 Feb;40(2):e137-9. doi: 10.1097/RLU.0000000000000538.
Focal Increased F-18 FP-CIT Uptake in a Recent Ischemic Lesion in the Frontal Lobe
J Alzheimers Dis. 2015;44(3):963-75. doi: 10.3233/JAD-141623.
Effects of Amyloid and Small Vessel Disease on White Matter Network Disruption
Int J Pharm. 2015 Jan 15;478(1):251-7. doi: 10.1016/j.ijpharm.2014.11.049. Epub 2014 Nov 25.
Resveratrol-loaded polymeric nanoparticles suppress glucose metabolism and tumor growth in vitro and in vivo
Clin Nucl Med. 2015 Jan;40(1):85-7. doi: 10.1097/RLU.0000000000000496.
F-18-FDG PET/CT in a Case of Parasite Infection Mimicking Lung and Breast Malignancy
J Nucl Med. 2015 Jan;56(1):153-8. doi: 10.2967/jnumed.114.147603. Epub 2014 Dec 18.
F-18-FDG PET/CT Monitoring of beta 3 Agonist-Stimulated Brown Adipocyte Recruitment in White Adipose Tissue
J Surg Oncol. 2014 Jun;109(8):760-3. doi: 10.1002/jso.23588. Epub 2014 Mar 7.
Prognostic value of lymphoscintigraphy in patients with gynecological cancer-related lymphedema
J Nucl Med. 2014 May;55(5):743-8. doi: 10.2967/jnumed.113.130716. Epub 2014 Apr 3.
Prediction of Occult Lymph Node Metastasis by Metabolic Parameters in Patients with Clinically N0 Esophageal Squamous Cell Carcinoma
Eur J Neurol. 2014 May;21(5):744-51. doi: 10.1111/ene.12376. Epub 2014 Feb 4.
Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type
JAMA Psychiatry. 2014 Apr;71(4):412-22. doi: 10.1001/jamapsychiatry.2013.4506.
Synergistic Effects of Ischemia and beta-Amyloid Burden on Cognitive Decline in Patients With Subcortical Vascular Mild Cognitive Impairment
Neurology. 2014 Apr 29;82(17):1529-35. doi: 10.1212/WNL.0000000000000360. Epub 2014 Mar 28.
Seoul criteria for PiB(-) subcortical vascular dementia based on clinical and MRI variables
Ann Vasc Surg. 2014 Apr;28(3):673-8. doi: 10.1016/j.avsg.2013.02.025. Epub 2013 Dec 2.
Diagnosis and Whole Body Screening Using Blood Pool Scintigraphy for Evaluating Congenital Vascular Malformations
J Alzheimers Dis. 2014;40(2):285-95. doi: 10.3233/JAD-132072.
Shape Changes of the Basal Ganglia and Thalamus in Alzheimer's Disease: A Three-Year Longitudinal Study
Neurobiol Aging. 2014 Feb;35(2):291-300. doi: 10.1016/j.neurobiolaging.2013.08.017. Epub 2013 Sep 27.
Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment
J Alzheimers Dis. 2014;40(4):877-86. doi: 10.3233/JAD-130461.
White Matter Hyperintensities are associated with Amyloid Burden in APOE4 Non-Carriers
Clin Nucl Med.?2014 Nov;39(11):980-3. doi: 10.1097/RLU.0000000000000363.
F-18-FDG PET/CT in a Case of Multifocal Skeletal Tuberculosis Without Pulmonary Disease and Potential Role for Monitoring Treatment Response
Eur Neurol. 2014;72(5-6):299-305. doi: 10.1159/000365286. Epub 2014 Oct 14.
Neovascularization Precedes Occlusion in Moyamoya Disease: Angiographic Findings in 172 Pediatric Patients
Oxidized Low-Density Lipoprotein Stimulates Macrophage F-18-FDG Uptake via Hypoxia-Inducible Factor-1 alpha Activation Through Nox2-Dependent Reactive Oxygen Species Generation
Neurobiol Aging. 2014 Jan;35(1):254-60. doi: 10.1016/j.neurobiolaging.2013.06.026. Epub 2013 Aug 7.
Effects of cerebrovascular disease and amyloid beta burden on cognition in subjects with subcortical vascular cognitive impairment
Mol Imaging. 2014;13:1-7.
Annexin V Imaging Detects Diabetes-Accelerated Apoptosis and Monitors the Efficacy of Benfotiamine Treatment in Ischemic Limbs of Mice
Bioconjug Chem. 2014 Mar 19;25(3):601-10. doi: 10.1021/bc500020g. Epub 2014 Feb 19.
Tumor-Homing Glycol Chitosan-Based Optical/PET Dual Imaging Nanoprobe for Cancer Diagnosis
Dig Dis Sci. 2014 Mar;59(3):607-13. doi: 10.1007/s10620-013-2957-6. Epub 2013 Dec 11.
Hepatic Glucose Uptake Is Increased in Association with Elevated Serum gamma-Glutamyl Transpeptidase and Triglyceride
Nucl Med Biol. 2014 Jan;41(1):51-7. doi: 10.1016/j.nucmedbio.2013.09.005. Epub 2013 Oct 8.
Ga-68-NODAGA-VEGF(121) for in vivo imaging of VEGF receptor expression
J Nucl Med. 2013 Dec;54(12):2070-6. doi: 10.2967/jnumed.113.119602. Epub 2013 Oct 31.
Relation of Carotid Artery F-18-FDG Uptake to C-Reactive Protein and Framingham Risk Score in a Large Cohort of Asymptomatic Adults
J Nucl Med. 2013 Dec;54(12):2161-7. doi: 10.2967/jnumed.112.115436. Epub 2013 Nov 12.
Resveratrol Suppresses Cancer Cell Glucose Uptake by Targeting Reactive Oxygen Species-Mediated Hypoxia-Inducible Factor-1 alpha Activation
Biomaterials. 2013 Sep;34(28):6839-45. doi: 10.1016/j.biomaterials.2013.05.051. Epub 2013 Jun 17.
A vascular endothelial growth factor 121 (VEGF(121))-based dual PET/optical probe for in vivo imaging of VEGF receptor expression
Cancer Biother Radiopharm. 2013 Jul-Aug;28(6):488-93. doi: 10.1089/cbr.2012.1353. Epub 2013 Jun 13.
I-131-MIBG Targeting of Neuroblastoma Cells Is Acutely Enhanced by KCl Stimulation through the Calcium/Calmodulin-Dependent Kinase Pathway
Mol Pharm. 2013 Jun 3;10(6):2190-8. doi: 10.1021/mp300601r. Epub 2013 May 6.
Facile Method To Radiolabel Glycol Chitosan Nanoparticles with Cu-64 via Copper-Free Click Chemistry for MicroPET Imaging
Neurosci Lett. 2013 Apr 29;541:184-9. doi: 10.1016/j.neulet.2013.02.022. Epub 2013 Feb 26.
alpha 2-Adrenergic agonists including xylazine and dexmedetomidine inhibit norepinephrine transporter function in SK-N-SH cells
Eur J Nucl Med Mol Imaging. 2013 Jan;40(2):198-206. doi: 10.1007/s00259-012-2266-x. Epub 2012 Oct 25.
In vivo characterization of Ga-68-NOTA-VEGF(121) for the imaging of VEGF receptor expression in U87MG tumor xenograft models
Nanotechnology. 2012 Dec 14;23(49):495102. doi: 10.1088/0957-4484/23/49/495102. Epub 2012 Nov 13.
Hydrazinonicotinamide prolongs quantum dot circulation and reduces reticuloendothelial system clearance by suppressing opsonization and phagocyte engulfment
Nucl Med Biol. 2012 Nov;39(8):1122-7. doi: 10.1016/j.nucmedbio.2012.06.007. Epub 2012 Jul 20.
EGF receptor targeted tumor imaging with biotin-PEG-EGF linked to Tc-99m-HYNIC labeled avidin and streptavidin
Nucl Med Biol. 2012 Nov;39(8):1251-60. doi: 10.1016/j.nucmedbio.2012.08.003. Epub 2012 Sep 19.
Quantification of early adipose-derived stem cell survival: comparison between sodium iodide symporter and enhanced green fluorescence protein imaging
Ann Nucl Med. 2012 Nov;26(9):715-22. doi: 10.1007/s12149-012-0633-0. Epub 2012 Jul 17.
Effects of coverage extent and slice skipping on mean and maximum arterial F-18-FDG uptake ratios in patients with carotid plaque
Clin Nucl Med. 2012 Oct;37(10):e241-4. doi: 10.1097/RLU.0b013e318252d1ea.
C-11-Methionine PET/CT and MRI of Primary Central Nervous System Diffuse Large B-cell Lymphoma Before and After High-Dose Methotrexate
Neuropsychobiology. 2012;66(2):106-11. doi: 10.1159/000337740. Epub 2012 Jul 17.
Regional Brain Metabolism and Treatment Response in Panic Disorder Patients: An [F-18]FDG-PET Study
Clin Nucl Med. 2012 Jul;37(7):663-8. doi: 10.1097/RLU.0b013e3182478bf2.
Apparent Relative Hypermetabolism of Selective Brain Areas in Huntington Disease and Importance of Reference Region for Analysis
Nucl Med Biol. 2012 Apr;39(3):423-8. doi: 10.1016/j.nucmedbio.2011.09.004. Epub 2011 Nov 12.
Combination of nitric oxide stimulation with high-dose F-18-FDG promotes apoptosis and enhances radiation therapy of endothelial cells
Nucl Med Commun. 2012 Mar;33(3):255-61. doi: 10.1097/MNM.0b013e32834fc5e6.
Differentiation of liver transplantation complications by quantitative analysis of dynamic hepatobiliary scintigraphy
J Med Chem. 2012 Jan 26;55(2):883-92. doi: 10.1021/jm201400q. Epub 2012 Jan 11.
Synthesis and Evaluation of (18)F-Labeled Styryltriazole and Resveratrol Derivatives for beta-Amyloid Plaque Imaging
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Synthesis and in vitro evaluation of 2-[11C]methoxyestradiol-3,17 ss-O,O-bissulfamate for in vivo studies of angiogenesis
J Nucl Med. 2011 Sep;52(9):1457-64. doi: 10.2967/jnumed.111.087619. Epub 2011 Aug 17.
(99)mTc-Hydrazinonicotinamide Epidermal Growth Factor-Polyethylene Glycol-Quantum Dot Imaging Allows Quantification of Breast Cancer Epidermal Growth Factor Receptor Expression and Monitors Receptor Downregulation in Response to Cetuximab Therapy
Nucl Med Biol. 2011 May;38(4):541-7. doi: 10.1016/j.nucmedbio.2010.11.010.
Binding of 2-[F-18]fluoro-CP-118,954 to mouse acetylcholinesterase: microPET and ex vivo Cerenkov luminescence imaging studies
J Nucl Med. 2010 Nov;51(11):1740-7. doi: 10.2967/jnumed.110.074708. Epub 2010 Oct 18.
17 beta-Estradiol Augments F-18-FDG Uptake and Glycolysis of T47D Breast Cancer Cells via Membrane-Initiated Rapid PI3K-Akt Activation
Nucl Med Biol. 2009 Nov;36(8):967-74. doi: 10.1016/j.nucmedbio.2009.06.010. Epub 2009 Oct 3.
Trypsinization severely perturbs radioiodide transport via membrane Na/I symporter proteolysis: implications for reporter gene imaging
Mov Disord. 2009 Aug 15;24(11):1650-5. doi: 10.1002/mds.22649.
MIBG Scintigraphy for Differentiating Parkinson's Disease with Autonomic Dysfunction from Parkinsonism-Predominant Multiple System Atrophy
Phys Med Biol. 2009 Jul 21;54(14):4547-59. doi: 10.1088/0031-9155/54/14/011. Epub 2009 Jun 26.
Development of a dual modality imaging system: a combined gamma camera and optical imager
Bioconjug Chem. 2009 Jun;20(6):1139-45. doi: 10.1021/bc800472a.
17-[4-(2-[F-18]Fluoroethyl)-1H-1,2,3-triazol-1-yl]-6-thia-heptadecanoic Acid: A Potential Radiotracer for the Evaluation of Myocardial Fatty Acid Metabolism
Cancer Biother Radiopharm. 2009 Apr;24(2):201-8. doi: 10.1089/cbr.2008.0555.
Effects of Theophylline on Radioiodide Uptake in MCF-7 Breast Cancer and NIS Gene-Transduced SNU-C5 Colon Cancer Cells
J Nucl Med. 2009 Apr;50(4):618-24. doi: 10.2967/jnumed.108.059386. Epub 2009 Mar 16.
Fibronectin Stimulates Endothelial Cell F-18-FDG Uptake Through Focal Adhesion Kinase-Mediated Phosphatidylinositol 3-Kinase/Akt Signaling
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Optimization of a Silicon Drift Detector Module for a Gamma Camera
Molecular Imaging of Angiogenesis
J Nucl Med. 2008 Dec;49(12):1966-72. doi: 10.2967/jnumed.108.055764. Epub 2008 Nov 7.
Mitogen-Activated Protein Kinase Signaling Enhances Sodium Iodide Symporter Function and Efficacy of Radioiodide Therapy in Nonthyroidal Cancer Cells
J Nucl Med. 2008 Aug;49(8):1277-82. doi: 10.2967/jnumed.108.052233. Epub 2008 Jul 16.
Reversal of vascular F-18-FDG uptake with plasma high-density lipoprotein elevation by atherogenic risk reduction
Clin Neurol Neurosurg. 2008 Jul;110(7):657-61. doi: 10.1016/j.clineuro.2008.03.014. Epub 2008 May 23.
Potential value of radionuclide cisternography in diagnosis and management planning of spontaneous intracranial hypotension
J Med Chem. 2008 Jun 26;51(12):3630-4. doi: 10.1021/jm800049h. Epub 2008 May 27.
16-Cyclopentadienyl tricarbonyl Tc-99m 16-oxo-hexadecanoic acid: Synthesis and evaluation of fatty acid metabolism in mouse myocardium
Arch Pharm Res. 2008 May;31(5):587-93. doi: 10.1007/s12272-001-1197-2. Epub 2008 May 15.
A F-18-labeled glucose analog: Synthesis using a click labeling method and in vitro evaluation
Int J Cardiovasc Imaging. 2008 Mar;24(3):277-81. Epub 2007 Sep 5.
Myocardial perfusion defects and coronary risk factors in symptomatic and asymptomatic elderly women
Eur J Nucl Med Mol Imaging. 2008 Mar;35(3):554-61. Epub 2007 Oct 13.
Effects of anesthetic agents on cellular I-123-MIBG transport and in vivo I-123-MIBG biodistribution
Mov Disord. 2008 Jan 30;23(2):207-11.
Therapeutic effect of repetitive transcranial magnetic stimulation in Parkinson's disease: Analysis of [C-11] raclopride PET study
World J Surg. 2008 Jan;32(1):69-75.
Comparison of uptake characteristics and prognostic value of Tl-201 and F-18-FDG in esophageal cancer
Bioorg Med Chem. 2007 Dec 15;15(24):7755-64. Epub 2007 Sep 1.
Synthesis of Tc-99m labeled glucosamino-Asp-cyclic(Arg-Gly-Asp-D-Phe-Lys) as a potential angiogenesis imaging agent
Cancer Biother Radiopharm. 2007 Oct;22(5):704-12.
Direct targeting of tumor cell F1F0 ATP-synthase by radioiodine angiostatin in vitro and in vivo
Nucl Med Biol. 2007 Aug;34(6):625-31.
2-[methyl-C-11]methoxyestradiol: synthesis, evaluation and pharmacokinetics for in vivo studies on angiogenesis
Nucl Med Commun. 2007 Jul;28(7):561-6.
Synthesis and evaluation of radioiodine-labelled CP-118,954 for the in-vivo imaging of acetylcholinesterase
Bioconjug Chem. 2007 Jul-Aug;18(4):1332-7. Epub 2007 May 16.
Tc-99m(CO)(3)-15-[N-(Acetyloxy)-2-picolylamino]pentadecanoic acid: A potential radiotracer for evaluation of fatty acid metabolism
Curr Pharm Des. 2007;13(1):17-31.
Targeted in vivo imaging of angiogenesis: Present status and perspectives
J Nucl Med. 2006 Dec;47(12):2000-7.
Favorable biokinetic and tumor-targeting properties of Tc-99m-labeled glucosamino RGD and effect of paclitaxel therapy
Nucl Med Commun. 2006 Nov;27(11):919-24.
Incidence and radio-uptake patterns, of femoral head avascular osteonecrosis at 1 year after renal transplantation: a prospective study with planar bone scintigraphy
J Nucl Med. 2006 Nov;47(11):1851-7.
Evidence that myocardial Na/I symporter gene imaging does not perturb cardiac function
Ann Nucl Med. 2006 Oct;20(8):535-40.
Pharmacokinetics and biodistribution of a small radioiodine labeled nerve growth factor fragment
J Med Chem. 2006 Oct 5;49(20):6111-9.
Curcumin and dehydrozingerone derivatives: Synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging
Int J Cardiovasc Imaging. 2006 Oct;22(5):663-70. Epub 2006 Apr 21.
Depressed heart rate response to vasodilator stress for myocardial SPECT predicts mortality in patients after myocardial infarction
IEEE Trans Nucl Sci. 2004 Feb;51(1):63-67.
A compact SPECT/CT system for small animal imaging
Characteristics and regulation of I-123-MIBG transport in cultured pulmonary endothelial cells
Nucl Med Biol. 2006 Feb;33(2):165-72.
In vitro metabolism studies of F-18-labeled 1-phenylpiperazine using mouse liver S9 fraction
Nucl Med Biol. 2006 Feb;33(2):255-62.
Synthesis and evaluation of 4-[F-18]fluorothalidomide for the in vivo studies of angiogenesis
Nucl Med Biol. 2006 Jan;33(1):91-4.
Is subnanomolar binding affinity required for the in vivo imaging of acetylcholinesterase Studies on F-18-labeled G379
Nucl Med Biol. 2005 Nov;32(8):845-50.
Distribution and pharmacokinetic analysis of angiostatin radioiodine labeled with high stability
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Performance amelioration for small animal SPECT using optimized pinhole collimator and image correction technique
J Nucl Med. 2005 Sep;46(9):1531-6.
Effects of anesthetic agents and fasting duration on F-18-FDG biodistribution and insulin levels in tumor-bearing mice
Nucl Med Biol. 2005 Aug;32(6):561-6.
PMA-enhanced neutrophil [F-18]FDG uptake is independent of integrin occupancy but requires PI3K activity
J Nucl Med. 2005 Apr;46(4):652-7.
Accuracy of myocardial sodium/iodide symporter gene expression imaging with radioiodide: Evaluation with a dual-gene adenovirus vector
J Nucl Med. 2005 Mar;46(3):472-8.
Radiolabeled RGD uptake and alpha(v) integrin expression is enhanced in ischemic murine hindlimbs
J Nucl Med. 2005 Feb;46(2):365-70.
Nitric oxide stimulates F-18-FDG uptake in human endothelial cells through increased hexokinase activity and GLUT1 expression
Nucl Med Biol. 2005 Feb;32(2):185-91.
Synthesis and evaluation of 2-[F-18]fluoro-CP-118,954 for the in vivo mapping of acetylcholinesterase
Phys Med Biol. 2004 Jul 7;49(13):2881-90.
Optimization of dual layer phoswich detector consisting of LSO and LuYAP for small animal PET
Phys Med Biol. 2004 Nov 7;49(21):4961-70.
Performance improvement of small gamma camera using NaI(Tl) plate and position sensitive photo-multiplier tubes
Phys Med Biol. 2004 Jul 7;49(13):2881-90.
Characterization of dual layer phoswich detector performance for small animal PET using Monte Carlo simulation
Nucl Med Commun. 2004 Jun;25(6):591-6.
Synthesis and evaluation of 5,7-dihydro-3-[2-[1-(4-[F-18] fluorobenzyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]1,2-benzisoxazol-6-one for in vivo mapping of acetylcholinesterase
Eur J Nucl Med Mol Imaging. 2004 Mar;31(3):433-8. Epub 2004 Jan 27.
Targeting of lacZ reporter gene expression with radioiodine-labelled phenylethyl-beta-D-thiogalactopyranoside
Am J Cardiol. 2004 Mar 1;93(5):549-53.
Identification of proximal left anterior descending artery stenosis with thallium-201 defect patterns in patients with angina pectoris
Bioorg Med Chem. 2004 Mar 1;12(5):859-64.
Synthesis of radioiodine labeled dibenzyl disulfide for evaluation of tumor cell uptake
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1161-3.
Synthesis of 7 '-[I-123]iodo-D-luciferin for in vivo studies of firefly luciferase gene expression
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Evaluation of maximum-likelihood position estimation with Poisson and Gaussian noise models in a small gamma camera
Bioconjug Chem. 2004 Jan-Feb;15(1):121-7.
8-cyclopentadienyltricarbonyl Tc-99m 8-oxooctanoic acid: A novel radiotracer for evaluation of medium chain fatty acid metabolism in the liver
Bioconjug Chem. 2004 Jan-Feb;15(1):104-11.
Potential and practical adrenomedullary PET radiopharmaceuticals as an alternative to m-iodobenzylguanidine: m-(omega-[F-18]fluoroalkyl)benzylguanidines
J Nucl Med. 2004 Jan;45(1):124-8.
Augmented F-18-FDG uptake in activated monocytes occurs during the priming process and involves tyrosine kinases and protein kinase C
Am J Cardiol. 2003 Dec 15;92(12):1458-61.
Prognostic value of cardiac autonomic neuropathy independent and incremental to perfusion defects in patients with diabetes and suspected coronary artery disease
Hepatogastroenterology. 2003 Nov-Dec;50(54):1983-6.
Bone scintigraphy of skeletal metastasis in hepatoma patients treated by TAE
Int J Cardiovasc Imaging. 2003 Oct;19(5):381-8.
Myocardial thallium defects in apical hypertrophic cardiomyopathy are associated with a benign prognosis - Thallium defects in apical hypertrophy
Nucl Med Commun. 2003 Sep;24(9):1003-9.
Cell uptake and tissue distribution of radioiodine labelled D-luciferin: implications for luciferase based gene imaging
Eur J Nucl Med Mol Imaging. 2003 Jul;30(7):1032-7. Epub 2003 Jan 30.
Specific endothelial binding and tumor uptake of radiolabeled angiostatin
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Optimization of pinhole collimator for small animal SPECT using Monte Carlo simulation
Carbohydr Res. 2003 Jan 2;338(1):29-34.
Synthesis of radioiodine-labeled 2-phenylethyl 1-thio-beta-D-galactopyranoside for imaging of LacZ gene expression
Nucl Med Commun. 2002 Jun;23(6):551-7.
Use of insulin to improve [F-18]fluorodeoxyglucose labelling and retention for in vivo positron emission tomography imaging of monocyte trafficking
Circulation. 2001 Jul 17;104(3):330-5.
Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
Nucl Med Biol. 2001 May;28(4):391-5.
A simple and efficient in vitro method for metabolism studies of radiotracers
J Nucl Cardiol. 2001 Mar-Apr;8(2):129-35.
Dipyridamole myocardial SPECT with low heart rate response indicates cardiac autonomic dysfunction in patients with diabetes
Am J Cardiol. 2001 Feb 15;87(4):456-9, A6.
Usefulness of diabetic retinopathy as a marker of risk for thallium myocardial perfusion defects in non-insulin-dependent diabetes mellitus
Phys Med Biol. 2000 Nov;45(11):3481-8.
Development of a miniature scintillation camera using an NaI(Tl) scintillator and PSPMT for scintimammography
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Comparison of [F-18]fluoropropylating agents for F-18-radiolabeling of amines
Nucl Med Biol. 2000 Nov;27(8):741-4.
Synthesis and biological evaluation of 1-(4-[F-18] fluorobenzyl)-4-[(5,6-dimethoxy-1-oxoindan-1-yl) methyl]piperidine for in vivo studies of acetylcholinesterase
Nucl Med Biol. 2000 Apr;27(3):263-7.
Syntheses and biological evaluation of F-18-labeled 3-(1-benzyl-piperidin-4-yl)-1-(1-methyl-1H-indol-3-yl) propan-1-ones for in vivo mapping of acetylcholinesterase
Am J Pathol. 1999 Nov;155(5):1661-70.
Up-regulation of insulin-like growth factor-II expression is a feature of trkA but not trkB activation in SH-SY5Y neuroblastoma cells
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Re-evaluation of 3-bromopropyl triflate as the percursor in the preparation of 3-[F-18]fluoropropyl bromide