Professor Seo Sang Won’s Paper on Cerebral Cortex Change by Sex in Alzheimer’s Disease Published in International Journal


After a five-year longitudinal study on cortical change in Alzheimer patients, the research team led by Professor Seo Sang Won (Samsung Medical Center Department of Neurology) has uncovered that female patients’ cortical thickness in various cerebral regions relevant to Alzheimer-related cognitive functions degrade faster than that of male patients.


This result can be explained by the fact that female patients’ brains form local neural networks that are more efficient in some areas, receive better neural protection through hormones, and subsequently have greater resistance to Alzheimer. This indicates that women have relatively better cerebral reserve capacity that allows them to maintain brain functions longer, but once the critical point has been reached, the deterioration becomes faster than that of male patients.


The study is meaningful in that it can assist the diagnosis of Alzheimer’s disease by allowing the physicians to better understand the disease and anticipate its progress from the patient’s sex.


The study has been published on the journal’s online issue on August 21st, under the title: “Sex-Related Reserve Hypothesis in Alzheimer’s Disease: Changes in Cortical Thickness with a Five-Year Longitudinal Follow-Up” (lead author: Professor Lee Ju Yeon, Chungnam National University Department of Neurology; corresponding author: Professor Seo Sang Wong, Samsung Medical Center; IF=3.73).